Etodesnitazene (Desnitroetonitazene, Etazen, Etazene, Etazone) is a
benzimidazole derived
opioid analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
drug, which was originally developed in the late 1950s alongside
etonitazene and a range of related derivatives. It is many times less potent than etonitazene itself, but still 70x more potent than
morphine in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by piperidine or pyrrolidine rings also retain significant activity (10x and 20x morphine respectively). Etodesnitazene has been sold as a
designer drug, first being identified in both Poland and Finland in March 2020.
See also
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Brorphine
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Etonitazepyne
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Isotonitazene
Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans ...
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Metonitazene
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Metodesnitazene
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MCHB-1
MCHB-1 is a benzimidazole derived drug which was researched as an analgesic but never developed for medical use. It acts as a potent agonist of the CB2 receptor, with an EC50 of 0.52nM at CB2, and ~30x selectivity over CB1 (Ki of 110nM at CB1 v ...
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List of benzimidazole opioids
Benzimidazole opioids, also known as nitazenes, are a class of synthetic opioids with an unusual benzimidazole structure often referred to as opioid New Psychoactive Substances (opioid NPS). First synthesized in the 1950s by CIBA Pharmaceuticals ...
References
Analgesics
Designer drugs
Opioids
Benzimidazoles
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