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The European Molecular Biology Laboratory (EMBL) is an
intergovernmental organization Globalization is social change associated with increased connectivity among societies and their elements and the explosive evolution of transportation and telecommunication technologies to facilitate international cultural and economic exchange. ...
dedicated to
molecular biology Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...
research and is supported by 29 member states, two prospect member states, and one associate member state. EMBL was created in 1974 and is funded by public research money from its member states. Research at EMBL is conducted by more than 110 independent research groups and service teams covering the spectrum of molecular biology. The Laboratory operates from six sites: the main laboratory in
Heidelberg Heidelberg (; ; ) is the List of cities in Baden-Württemberg by population, fifth-largest city in the States of Germany, German state of Baden-Württemberg, and with a population of about 163,000, of which roughly a quarter consists of studen ...
(Germany), and sites in
Barcelona Barcelona ( ; ; ) is a city on the northeastern coast of Spain. It is the capital and largest city of the autonomous community of Catalonia, as well as the second-most populous municipality of Spain. With a population of 1.6 million within c ...
(Spain),
Grenoble Grenoble ( ; ; or ; or ) is the Prefectures in France, prefecture and List of communes in France with over 20,000 inhabitants, largest city of the Isère Departments of France, department in the Auvergne-Rhône-Alpes Regions of France, region ...
(France),
Hamburg Hamburg (, ; ), officially the Free and Hanseatic City of Hamburg,. is the List of cities in Germany by population, second-largest city in Germany after Berlin and List of cities in the European Union by population within city limits, 7th-lar ...
(Germany),
Hinxton Hinxton is a village in South Cambridgeshire, England. The River Cam runs through the village, as does the Cambridge to Liverpool Street station, Liverpool Street railway, though the village has no station. Hinxton parish's southern boundarie ...
(the
European Bioinformatics Institute The European Bioinformatics Institute (EMBL-EBI) is an intergovernmental organization (IGO) which, as part of the European Molecular Biology Laboratory (EMBL) family, focuses on research and services in bioinformatics. It is located on the Wel ...
(EBI), in England), and
Rome Rome (Italian language, Italian and , ) is the capital city and most populated (municipality) of Italy. It is also the administrative centre of the Lazio Regions of Italy, region and of the Metropolitan City of Rome. A special named with 2, ...
(Italy). EMBL groups and laboratories perform basic research in molecular biology and molecular medicine as well as train scientists, students, and visitors. The organization aids in the development of services, new instruments and methods, and technology in its member states.
Israel Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Isr ...
is the only full member state located outside Europe.


History

EMBL was the idea of Leó Szilárd,
James Watson James Dewey Watson (born April 6, 1928) is an American molecular biology, molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper in ''Nature (journal), Nature'' proposing the Nucleic acid ...
and
John Kendrew Sir John Cowdery Kendrew, (24 March 1917 – 23 August 1997) was an English biochemist, crystallographer, and science administrator. Kendrew shared the 1962 Nobel Prize in Chemistry with Max Perutz, for their work at the Cavendish Labo ...
. Their goal was to create an international research centre, similar to
CERN The European Organization for Nuclear Research, known as CERN (; ; ), is an intergovernmental organization that operates the largest particle physics laboratory in the world. Established in 1954, it is based in Meyrin, western suburb of Gene ...
, to rival the strongly American-dominated field of molecular biology. Kendrew served as the first
Director general A director general, general director or director-general (plural: ''directors general'', ''general directors'', ''directors-general'', ''director generals'' or ''director-generals'') is a senior executive officer, often the chief executive officer ...
of EMBL until 1982 and was succeeded by Lennart Philipson. From 1993 to 2005,
Fotis Kafatos Fotis Constantine Kafatos (; 16 April 1940 – 18 November 2017) was a Greek biologist. Between 2007 and 2010 he was the founding president of the European Research Council, European Research Council (ERC). He chaired the ERC Scientific Council ...
, served as director and was succeeded by Iain Mattaj, EMBL's fourth director, from 2005 to 2018. In January 2019,
Edith Heard Edith Heard (born 1965) is a British-French researcher in epigenetics who has been serving as the Director General of the European Molecular Biology Laboratory (EMBL) since January 2019. She is also Professor at the Collège de France, holding ...
became the fifth director of EMBL and the first woman to hold this position. Heard announced the organisation's five-year scientific programme Molecules to Ecosystems on 19 January 2022.


Research

Each EMBL site has a specific research field. The EMBL-EBI is a hub for
bioinformatics Bioinformatics () is an interdisciplinary field of science that develops methods and Bioinformatics software, software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, ...
research and services, developing and maintaining a large number of scientific databases that are free of charge. At Grenoble and Hamburg, research is focused on
structural biology Structural biology deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every level of organization. Early structural biologists throughout the 19th and early 20th centuries we ...
. The EMBL Rome site is dedicated to the study of
epigenetics In biology, epigenetics is the study of changes in gene expression that happen without changes to the DNA sequence. The Greek prefix ''epi-'' (ἐπι- "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in ...
and
neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...
. Scientists at EMBL Barcelona are exploring how tissues and organs function and develop, in health and disease. At the headquarters in Heidelberg, there are units in
cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...
and
biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...
,
developmental biology Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...
,
genome biology ''Genome Biology'' is a peer-reviewed open access scientific journal covering research in genomics. It was established in 2000 and is published by BioMed Central. The chief editor is currently Andrew Cosgrove ( BioMed Central, New York). Abstract ...
, and structural and
computational biology Computational biology refers to the use of techniques in computer science, data analysis, mathematical modeling and Computer simulation, computational simulations to understand biological systems and relationships. An intersection of computer sci ...
, as well as service groups complementing the aforementioned research fields. Many scientific breakthroughs have been made at EMBL. The first systematic genetic analysis of embryonic development in the fruit fly was conducted at EMBL by
Christiane Nüsslein-Volhard Christiane (Janni) Nüsslein-Volhard (; born 20 October 1942) is a German developmental biologist and a 1995 Nobel Prize in Physiology or Medicine laureate. She is the only woman from Germany to have received a Nobel Prize in the sciences. N� ...
and
Eric Wieschaus Eric Francis Wieschaus (born June 8, 1947 in South Bend, Indiana) is an American Evolutionary developmental biology, evolutionary developmental biologist and 1995 Nobel Prize-winner. Early life Born in South Bend, Indiana, he attended John Carro ...
, for which they were awarded the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
in 1995. In the early 1980s, Jacques Dubochet and his team at EMBL developed
cryogenic electron microscopy Cryogenic electron microscopy (cryo-EM) is a transmission electron microscopy technique applied to samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An ...
for biological structures. They were rewarded with the 2017
Nobel Prize in Chemistry The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outst ...
.


Scientific Services

EMBL has identified as a core mission the provision o
advanced experimental and data services
to external researchers, including structural biology, imaging and sequencing facilities at its five European sites. In 2021, EMBL completed a new centre for high-resolution light and electron microscopy at its Heidelberg Headquarters – th
EMBL Imaging Centre
The centre is open to visiting scientists worldwide and provides a unique service facility for the life sciences by combining the latest imaging technologies with expert advice and industry-led developments not yet otherwise available.


Training

Advanced training is one of EMBL's five core missions. Over the years, the Laboratory has established a number of training activities, of which the EMBL International PhD Programme (EIPP) is the flagship – it has a student body of about 200, and since 1997 has had the right to award its own degree, although currently students receive their degrees from partner universities. Other activities include the postdoctoral programme, including the EMBL Interdisciplinary Postdoctoral programme (EIPOD) and the Visitor Programme.


EMBL Advanced Training Centre

In March 2010, the EMBL Advanced Training Centre (ATC) was inaugurated on the main campus in Heidelberg. Shaped in the form of a double helix, it hosts scientific conferences, seminars and training courses, and provides access to training laboratories and lecture halls. The ATC also hosts EMBL's European Learning Lab for the Life Science
(ELLS)
which provides training for secondary school teachers on the latest developments in molecular biology, and runs a student outreach program.


Science and society

EMBL also runs an active Science and Society Programme which offers activities and events on current questions in life science research for the general public and the scientific community.
EMBL website


Membership

EMBL is currently supported by 29 member states, one associate member state, and two prospect member states.


See also

*
European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
* European Genome-phenome Archive


Notes and references


External links

* {{authority control Scientific organizations established in 1974 Heidelberg Intergovernmental organizations established by treaty International research institutes International scientific organizations based in Europe Medical and health organisations based in Baden-Württemberg Molecular biology institutes Medical research institutes in Germany Science and technology in Grenoble