Eukaryotic translation initiation factor 4 gamma 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''EIF4G1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The protein encoded by this gene is a component of the protein complex
eIF4F
Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the Five-prime cap, 5' cap of Messenger RNA, messenger RNAs (mRNAs) to promote eukaryotic translation initiation. The eIF4F complex is composed of three non-i ...
, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.
eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the
PABP and
eIF3
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. It is essential for most forms of Eukaryotic translation#Cap-dependent initiation, cap-dependent and Eukaryotic ...
.
Interactions
Eukaryotic translation initiation factor 4 gamma has been shown to
interact with
MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the ''MKNK1'' gene.
Interactions
MKNK1 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma
Eukaryotic t ...
,
EIF4A1
Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the ''EIF4A1'' gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A protein family, fa ...
,
EIF4E
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein in humans encoded by the ''EIF4E'' gene. eIF4E plays a central role in translation initiation and is involved in regulating protein synthesis. Its activity influences ...
,
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the ''MKNK2'' gene.
Interactions
MNK2 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma.
MNK2 has be ...
See also
*Eukaryotic initiation factor
Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an ...
References
Further reading
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{{Initiation factors