Dimethylallyl pyrophosphate (DMAPP; or alternatively, dimethylallyl diphosphate (DMADP); also isoprenyl pyrophosphate) is an isoprenoid precursor. It is a product of both the
mevalonate pathway and the
MEP pathway of isoprenoid precursor biosynthesis. It is an isomer of
isopentenyl pyrophosphate (IPP) and exists in virtually all life forms. The enzyme
isopentenyl pyrophosphate isomerase
Isopentenyl pyrophosphate isomerase (, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase, is an isomerase that catalyzes the conversion of the relatively un-reactive isopentenyl pyrophosphate (IPP) to the more-reactive elect ...
catalyzes isomerization between DMAPP and IPP.
In the mevalonate pathway DMAPP is synthesised from
mevalonic acid
Mevalonic acid (MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone. The carboxylate anion of mevalonic acid, which is the predominant form in biological environments, is known as ''mevalonat ...
. In contrast, DMAPP is synthesised from
HMBPP in the
MEP pathway.
At present, it is believed that there is crossover between the two pathways in organisms
that use both pathways to create
terpene
Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n > 1. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predominantly by plants, particularly conifers. Terpenes ...
s and
terpenoids, such as in plants, and that DMAPP is the crossover product.
References
External links
Organophosphates
Hemiterpenes
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