The term ''dromotropic'' derives from the Greek word δρόμος ''drómos'', meaning "running", a course, a race. A dromotropic agent is one which affects the conduction speed (in fact the magnitude of delay) in the
AV node
The atrioventricular node (AV node, or Aschoff-Tawara node) electrically connects the heart's atria and ventricles to coordinate beating in the top of the heart; it is part of the electrical conduction system of the heart. The AV node lies at the ...
, and subsequently the rate of electrical impulses in the heart.
Positive dromotropy increases
conduction
Conductor or conduction may refer to:
Biology and medicine
* Bone conduction, the conduction of sound to the inner ear
* Conduction aphasia, a language disorder
Mathematics
* Conductor (ring theory)
* Conductor of an abelian variety
* Condu ...
velocity (e.g.
epinephrine
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands a ...
stimulation), negative dromotropy decreases velocity (e.g.
vagal stimulation).
Non-dihydropyridine
calcium channel blockers
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., a ...
such as
verapamil
Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. It may also be use ...
block the slow inward calcium current in cardiac tissues, thereby having a negatively dromotropic, chronotropic and inotropic effect. This (and other) pharmacological effect makes these drugs useful in the treatment of
angina
Angina, also known as angina pectoris, is chest pain or pressure, usually caused by insufficient blood flow to the heart muscle (myocardium). It is most commonly a symptom of coronary artery disease.
Angina is typically the result of parti ...
pectoris. Conversely, they can lead to symptomatic disturbances in cardiac conduction and
bradyarrhythmias
Bradycardia, also called bradyarrhythmia, is a resting heart rate under 60 beats per minute (BPM). While bradycardia can result from various pathological processes, it is commonly a physiological response to cardiovascular conditioning or due t ...
, and may aggravate
left ventricular failure
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood.
Although symptoms vary based on which side of the heart is affected, HF typically pre ...
.
See also
*
Bathmotropic
Bathmotropic often refers to modifying the degree of membrane_potential#Cell_excitability, excitability specifically of the heart; in general, it refers to modification of the degree of excitability (threshold of excitation) of musculature in gene ...
*
Inotrope
An inotrope or inotropic is a drug or any substance that alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular ...
*
Catecholamines
A catecholamine (; abbreviated CA), most typically a 3,4-dihydroxyphenethylamine, is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine.
...
References
{{Cardiovascular physiology
Cardiovascular physiology