Drew Weissman (born September 7, 1959) is an American physician and immunologist known for his contributions to

RNA Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...

biology. Weissman is the inaugural Roberts Family Professor in Vaccine Research, director of the Penn Institute for RNA Innovation, and professor of medicine at the

Perelman School of Medicine at the University of Pennsylvania The Perelman School of Medicine (commonly known as Penn Med) is the medical school of the University of Pennsylvania, a Private university, private, Ivy League research university located in Philadelphia. Founded in 1765, the Perelman School of M ...

(Penn). Weissman's work underlies the development of

mRNA vaccine An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to b ...

s, the best known of which are those for COVID-19 produced by

BioNTech BioNTech SE ( ; or short for Biopharmaceutical New Technologies) is a German multinational biotechnology company headquartered in Mainz that develops immunotherapies and vaccines, particularly for cancer and infectious diseases. The compan ...

Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...

and

Moderna Moderna, Inc. ( ) is an American pharmaceutical and biotechnology company based in Cambridge, Massachusetts, that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to carry inst ...

. With

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

Katalin Karikó Katalin "Kati" Karikó (, ; born 17 January 1955) is a Hungarian-American biochemist who specializes in ribonucleic acid (RNA)-mediated mechanisms, particularly in vitro-Transcription (biology), transcribed messenger RNA (mRNA) for protein repla ...

, Weissman received the Nobel Prize in Physiology or Medicine in 2023 "for their discoveries concerning

nucleoside Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotid ...

base modifications that enabled the development of effective mRNA vaccines against COVID-19". Weissman has been a recipient and co-recipient of numerous awards, also including the prestigious

Lasker–DeBakey Clinical Medical Research Award Lasker–DeBakey Clinical Medical Research Award is one of four annual awards presented by the Lasker Foundation. The Lasker–DeBakey award is given to honor outstanding work for the understanding, diagnosis, prevention, treatment, and cure of di ...

. In 2022, he was elected to the

National Academy of Medicine The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineerin ...

and the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

Early life and education

Weissman was born in

Lexington, Massachusetts Lexington is a suburban town in Middlesex County, Massachusetts, United States, located 10 miles (16 km) from Downtown Boston. The population was 34,454 as of the 2020 United States census, 2020 census. The area was originally inhabited by ...

, on September 7, 1959, to Hal and Adele Weissman. Hal is

Jewish Jews (, , ), or the Jewish people, are an ethnoreligious group and nation, originating from the Israelites of History of ancient Israel and Judah, ancient Israel and Judah. They also traditionally adhere to Judaism. Jewish ethnicity, rel ...

and Adele is

Italian Italian(s) may refer to: * Anything of, from, or related to the people of Italy over the centuries ** Italians, a Romance ethnic group related to or simply a citizen of the Italian Republic or Italian Kingdom ** Italian language, a Romance languag ...

. While his mother did not convert to

Judaism Judaism () is an Abrahamic religions, Abrahamic, Monotheism, monotheistic, ethnic religion that comprises the collective spiritual, cultural, and legal traditions of the Jews, Jewish people. Religious Jews regard Judaism as their means of o ...

, he grew up celebrating all the Jewish holidays. He grew up in Lexington and attended Lexington High School, graduating in 1977. Weissman received his

B.A. A Bachelor of Arts (abbreviated B.A., BA, A.B. or AB; from the Latin ', ', or ') is the holder of a bachelor's degree awarded for an undergraduate program in the liberal arts, or, in some cases, other disciplines. A Bachelor of Arts degree ...

and

M.A. A Master of Arts ( or ''Artium Magister''; abbreviated MA or AM) is the holder of a master's degree awarded by universities in many countries. The degree is usually contrasted with that of Master of Science. Those admitted to the degree have ...

degrees from

Brandeis University Brandeis University () is a Private university, private research university in Waltham, Massachusetts, United States. It is located within the Greater Boston area. Founded in 1948 as a nonsectarian, non-sectarian, coeducational university, Bra ...

in 1981, where he majored in

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

and

enzymology An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

and he worked in the lab of Gerald Fasman. He performed his graduate work in

immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...

and

microbiology Microbiology () is the branches of science, scientific study of microorganisms, those being of unicellular organism, unicellular (single-celled), multicellular organism, multicellular (consisting of complex cells), or non-cellular life, acellula ...

to receive his

M.D. A Doctor of Medicine (abbreviated MD, from the Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of physician. This ge ...

and

Ph.D. A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

in 1987 at

Boston University Boston University (BU) is a Private university, private research university in Boston, Massachusetts, United States. BU was founded in 1839 by a group of Boston Methodism, Methodists with its original campus in Newbury (town), Vermont, Newbur ...

. Afterward, Weissman did a residency at

Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School and one of the founding members of Beth Israel Lahey Health. It was formed out of the 1996 merger of Beth Israel Hospital (f ...

, followed by a

fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

ship at the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

(NIH), under the supervision of

Anthony Fauci Anthony Stephen Fauci ( ; born December 24, 1940) is an American physician-scientist and immunologist who served as the director of the National Institute of Allergy and Infectious Diseases (NIAID) from 1984 to 2022, and the chief medical ...

, then director of the

National Institute of Allergy and Infectious Diseases The National Institute of Allergy and Infectious Diseases (NIAID, ) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services. NIAID's mis ...

Career

In 1997, Weissman moved to the

University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...

to start his laboratory in order to study RNA and innate immune system biology. He is now the Roberts Family Professor in Vaccine Research at the university. At the university, Weissman, an immunologist studying vaccines, met his future colleague and collaborator

at a

photocopier A photocopier (also called copier or copy machine, and formerly Xerox machine, the generic trademark) is a machine that makes copies of documents and other visual images onto paper or plastic film quickly and cheaply. Most modern photocopiers ...

, where they sympathized about the lack of funding for RNA research. At the time, Karikó had been trying RNA therapy on

cerebral Cerebral may refer to: * Of or relating to the brain * Cerebrum, the largest and uppermost part of the brain * Cerebral cortex, the outer layer of the cerebrum * Retroflex consonant, also referred to as a cerebral consonant, a type of consonant so ...

diseases and

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

s. Immunologist Weissman began collaborating with biochemist Karikó, who switched her focus to the application of RNA technology to vaccines. Weissman’s support was critical in helping Karikó to continue and extend her research. Slowly they began to move the technology forward, solving problems one at a time. On the difficulty of gaining funding and recognition for their work, Weissman has commented "We had to fight the entire way." One of the major scientific obstacles they faced was that the RNA caused unwanted immune and inflammatory reactions as adverse

side effects In medicine, a side effect is an effect of the use of a medicinal drug or other treatment, usually adverse but sometimes beneficial, that is unintended. Herbal and traditional medicines also have side effects. A drug or procedure usually used ...

. Beginning in 2005, they published several landmark studies that used synthetic nucleosides to modify the RNA to prevent its degradation by the body. This breakthrough laid the groundwork for the use of RNA therapeutics, though the study received little attention at the time. Weissman and Karikó overcame another major obstacle by developing a delivery technique to package the mRNA in

lipid nanoparticles Lipid-based nanoparticles are very small spherical particles composed of lipids. They are a novel pharmaceutical drug delivery system (part of nanoparticle drug delivery), and a novel pharmaceutical formulation. There are many subclasses o ...

, a novel pharmaceutical drug delivery system for mRNA that protects the fragile molecule until it can reach the desired area of the body. They demonstrated the effectiveness of the delivery system in animals. In 2006, Weissman and Karikó co-founded RNARx. Their objective was to develop novel RNA therapies. In 2020 their modified RNA technology became the key foundational component of the Pfizer/BioNTech and Moderna COVID-19 vaccines, which were deployed worldwide against the

COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December ...

. Weissman has been collaborating with scientists at Thailand's

Chulalongkorn University Chulalongkorn University (CU; ; , ) is a public university, public Autonomous university, autonomous research university in Bangkok, Thailand. The university was originally founded during King Chulalongkorn's reign as a school for training ro ...

, most recently to develop and provide

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever ...

vaccines for the country and neighboring

low and middle income countries A developing country is a sovereign state with a less-developed industrial base and a lower Human Development Index (HDI) relative to developed countries. However, this definition is not universally agreed upon. There is also no clear agreemen ...

that may not have immediate access to the vaccine. Weissman's laboratory continues to actively research the use of mRNA for next-generation vaccines, gene editing, and mRNA therapeutics. Projects include development of a pan coronavirus vaccines, gene editing technology to enable genes that produce missing antibodies, and treatments for acute inflammatory conditions. Weissman hopes that mRNA technology can be used to develop vaccines against influenza, herpes, and HIV.

Recognition

For their mRNA-related work, Weissman and Karikó were awarded the 2023

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...

, the 2020

Rosenstiel Award The Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research is awarded by Brandeis University. It was established in 1971 "as an expression of the conviction that educational institutions have an important role to play in the en ...

, the

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

, the

Albany Medical Center Prize The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical ...

, the Lasker-DeBakey Clinical Medical Research Award, and the

BBVA Foundation Frontiers of Knowledge Award The BBVA Foundation Frontiers of Knowledge Awards () are an international award programme recognizing significant contributions in the areas of scientific research and cultural creation. The categories that make up the Frontiers of Knowledge Awards ...

(also with Robert S. Langer). Weissman obtained a honorary degree by the

Drexel University College of Medicine Drexel University College of Medicine is the medical school of Drexel University, a private research university in Philadelphia, Pennsylvania. The medical school represents the consolidation of two medical schools: Hahnemann Medical College, orig ...

. In 2021, he was awarded the

Princess of Asturias Award The Princess of Asturias Awards (, ), formerly the Prince of Asturias Awards from 1981 to 2014 (), are a series of annual prizes awarded in Spain by the Princess of Asturias Foundation (previously the Prince of Asturias Foundation) to individuals ...

in the category for Scientific Research. For 2022 he was awarded the

Breakthrough Prize in Life Sciences The Breakthrough Prize in Life Sciences is a scientific award, funded by internet entrepreneurs Mark Zuckerberg and Priscilla Chan of Facebook; Sergey Brin of Google; entrepreneur and venture capitalist Yuri Milner; and Anne Wojcicki, one of t ...

, the Jessie Stevenson Kovalenko Medal of the

NAS Nas (born 1973) is the stage name of American rapper Nasir Jones. Nas, NaS, or NAS may also refer to: Aviation * Nasair, a low-cost airline carrier and subsidiary based in Eritrea * National Air Services, an airline in Saudi Arabia ** Nas Air (S ...

jointly with Katalin Karikó and also the

Japan Prize is awarded to individuals whose original and outstanding achievements in science and technology are recognized as having advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind. As of 2024, the Japan Prize h ...

Also in 2022 he received the

Robert Koch Prize The Robert Koch Medal and Award are two prizes awarded annually by the German for excellence in the biomedical sciences. These awards grew out of early attempts by German physician Robert Koch to generate funding to support his research into the ...

and the

Tang Prize The Tang Prize ( zh, c=唐獎) is a set of Taiwanese biennial international awards bestowed in four fields: Sustainable Development, Biopharmaceutical Science, Sinology, and Rule of Law. Nomination and selection are conducted by an independent se ...

in Biopharmaceutical Science, the Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a nonprofit educational organization that recognizes some of the highest-achieving people in diverse fields and gives them the opportunity to meet one ano ...

, and was elected to the National Academy of Medicine and American Academy of Arts and Sciences. In 2023 he received the

Harvey Prize The Harvey Prize is an annual Israeli award for breakthroughs in science and technology, as well as contributions to peace in the Middle East granted by the Technion – Israel Institute of Technology, Technion in Haifa. The prize has become a ...

of the Technion in Israel (awarded for the year 2021). In 2022, Weissman and Karikó were awarded the Novo Nordisk Prize. According to a report in ''

The Washington Post ''The Washington Post'', locally known as ''The'' ''Post'' and, informally, ''WaPo'' or ''WP'', is an American daily newspaper published in Washington, D.C., the national capital. It is the most widely circulated newspaper in the Washington m ...

'', Weissman gets fan mail from people all over the world, thanking him for his work that made the COVID-19 vaccine possible — one said "You've made hugs and closeness possible again" — and asking him for a picture or his autograph. His name was included with Kariko in Time 2024 list of influential people in health.

Patents

Weissman is the co-inventor on several patents, including US8278036B2 and US8748089B2, both with his colleague Katalin Karikó, which detail the modifications required to make RNA suitable for vaccines and other therapies. Later, these patents were licensed to Gary Dahl, founder and CEO of Cellscript, who subsequently licensed the technology to Moderna and BioNTech to ultimately use in their COVID-19 vaccines.

References

External links

*
Drew Weissman, M.D., Ph.D.
at

{{DEFAULTSORT:Weissman, Drew 1959 births Living people People from Lexington, Massachusetts 20th-century American biologists 20th-century American chemists 20th-century American physicians 21st-century American biologists 21st-century American chemists 21st-century American physicians American biochemists American people of German-Jewish descent American people of Italian descent Boston University School of Medicine alumni Brandeis University alumni Jewish American scientists Nobel laureates in Physiology or Medicine Perelman School of Medicine at the University of Pennsylvania faculty Physician-scientists Physicians from Massachusetts Recipients of the Lasker–DeBakey Clinical Medical Research Award Scientists from Massachusetts University of Pennsylvania faculty 21st-century American Jews American Nobel laureates Jewish Nobel laureates Benjamin Franklin Medal (Franklin Institute) laureates Members of the National Academy of Medicine