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Dilazep is a
The reaction of bis-(3-hydroxypropyl)-ethylene diamine (1) with
vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, ...
that acts as an adenosine reuptake inhibitor.
It is used for the treatment of cardiopathy and renal disorder
The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...
s.Synthesis
The reaction of bis-(3-hydroxypropyl)-ethylene diamine (1) with 1-Bromo-3-chloropropane
1-Bromo-3-chloropropane is an organohalogen compound with the formula Br(CH2)3Cl. It is a colorless liquid, produced by free-radical addition of hydrogen bromide to allyl chloride. It is used as an alkylating agent to install the –(CH2)3Cl
an ...
(2) gives homopiperazine 9970-80-0
(3). Esterification by reaction with 3,4,5-Trimethoxybenzoyl Chloride 521-61-3
5 (five) is a number, numeral and digit. It is the natural number, and cardinal number, following 4 and preceding 6, and is a prime number. It has attained significance throughout history in part because typical humans have five digits on eac ...
(4) completed the synthesis of Dilazep (5).
See also
*Hexobendine
Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor.
Synthesis
The reaction between 3,4,5-trimethoxybenzoyl chloride 521-61-3(1) and 3-chloropropanol 27-30-5(2) gives the corresponding ester, i.e. 3-chloropropyl 3,4,5-tr ...
, a drug with similar chemical structure
References
Vasodilators Pyrogallol ethers Benzoate esters Diazepanes Adenosine reuptake inhibitors {{cardiovascular-drug-stub