Dihydropyridine calcium channel blockers are derivatives of

1,4-dihydropyridine 1,4-Dihydropyridine (DHP) is an organic compound with the formula CH2(CH=CH)2NH. The parent compound is uncommon, but derivatives of 1,4-dihydropyridine are important commercially and biologically. The pervasive cofactors NADH and NADPH are deriv ...

that are used as L-type calcium channel blockers. They are used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the

phenylalkylamine Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by ...

class such as

verapamil Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. It may also be use ...

) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the

smooth muscle Smooth muscle is one of the three major types of vertebrate muscle tissue, the others being skeletal and cardiac muscle. It can also be found in invertebrates and is controlled by the autonomic nervous system. It is non- striated, so-called bec ...

of the

blood vessel Blood vessels are the tubular structures of a circulatory system that transport blood throughout many Animal, animals’ bodies. Blood vessels transport blood cells, nutrients, and oxygen to most of the Tissue (biology), tissues of a Body (bi ...

walls.

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries): The pharmaceutical drug

finerenone Finerenone, marketed under the brand name Kerendia among others, is a medication used to reduce the risk of kidney function decline, kidney failure, cardiovascular death, non-fatal heart attacks, and hospitalization for heart failure in adul ...

is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an

antimineralocorticoid A mineralocorticoid receptor antagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which receptor antagonist, antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive t ...

References

{{Calcium channel blockers Calcium channel blockers

Class members

See also

References