Dexloxiglumide is a drug which acts as a

cholecystokinin antagonist A cholecystokinin receptor antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide hormone cholecystokinin (CCK). Classification There are two subtypes of this receptor known at present, defined as ...

, selective for the CCK_A subtype. It inhibits gastrointestinal motility and reduces gastric secretions, and despite older selective CCK_A antagonists such as lorglumide and devazepide having had only limited success in trials and ultimately never making it into clinical use, dexloxiglumide is being investigated as a potential treatment for a variety of gastrointestinal problems including

irritable bowel syndrome Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating, and changes in the consistency of bowel movements. These symptoms may ...

dyspepsia Indigestion, also known as dyspepsia or upset stomach, is a condition of impaired digestion. Symptoms may include upper abdominal fullness, heartburn, nausea, belching, or upper abdominal pain. People may also experience feeling full earlier ...

constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The Human feces, stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the ...

and

pancreatitis Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormone A hormone (from the Ancient Greek, Greek participle , "se ...

,{{cite journal , vauthors = Barrett TD, Yan W, Freedman JM, Lagaud GJ, Breitenbucher JG, Shankley NP , title = Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction , journal = British Journal of Pharmacology , volume = 153 , issue = 8 , pages = 1650–8 , date = April 2008 , pmid = 18297100 , pmc = 2438255 , doi = 10.1038/bjp.2008.44 and has had moderate success so far although trials are still ongoing.

References

Cholecystokinin antagonists Chloroarenes Benzamides Ethers