The Developmental Studies Hybridoma Bank (DSHB) is a National Resource established by the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

(NIH) in 1986 to bank and distribute at cost hybridomas and the monoclonal antibodies (mAbs) they produce to the basic science community worldwide. It is housed in the Department of Biology at the

University of Iowa The University of Iowa (U of I, UIowa, or Iowa) is a public university, public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is organized int ...

Description

The DSHB is directed by David R. Soll at the University of Iowa. There are currently over 5000 hybridomas in the DSHB collection. The DSHB has obtained hybridomas from a variety of individuals and institutions, the latter including the

Muscular Dystrophy Association Muscular Dystrophy Association (MDA) is an American nonprofit organization dedicated to supporting people living with muscular dystrophy, ALS, and related Neuromuscular disease, neuromuscular diseases. Founded in 1950 by Paul Cohen, who lived wi ...

, the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

, the

NIH Common Fund The National Institutes of Health Common Fund is an initiative of the National Institutes of Health (NIH) aimed at supporting research collaboration between two or more NIH institutes and centers (ICs). The fund offers flexible support for cuttin ...

, and the

European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 29 member states, two prospect member states, and one associate member state. EMBL was created in ...

(EMBL). The DSHB eagerly awaits new contributions. First time customers must agree to the DSHB terms of usage that products will be used for research purposes only, and that they cannot be commercialized or distributed to a third party. Researchers also agree to acknowledge both the DSHB and the contributing investigator and institution in publications that benefit from the use of DSHB products and provide to the DSHB citations of all publications. Individuals or institutions can deposit hybridomas for distribution at no cost. Contributing to the DSHB does not preclude the depositor from licensing cell lines for commercial purposes. The DSHB does not own any contributed intellectual property. The intellectual property remains that of the scientist and/or institution that banks the hybridomas. The DSHB covers the operating costs of maintaining, improving, producing and distributing products in the collection.

History

The DSHB was created in 1986 by the NIH to bank and distribute hybridomas and the monoclonal antibodies (mAbs) they produce to the general scientific community in order to facilitate research. The DSHB was moved from Johns Hopkins University to the University of Iowa in 1996, and placed under the directorship of David R. Soll. The DSHB has been self-funded since 1997 and relies on no outside funding.

Popular collections

:*Cardiac Muscle :*CD Markers :*Cell Adhesion :*Cell Biomarkers :*Cytoskeleton :*Disease Biomarkers :*EMBL Protein Binders (Affinomics) :*Enzymes :*Epitope Tags :*Extracellular Matrix :*Microbes (Bacteria, Fungi, Viruses) :*Neurodevelopment :*Muscular Dystrophy Association mAbs :*NIH Common Fund Protein Capture Reagents :*NIH NCI CPTAC Cancer Targets :*Receptors :*Organelle-specific Biomarkers :*RNA/DNA Regulation :*Secreted Proteins :*Epitope Tags :*Skeletal Muscle :*Transcription Factors

Noteworthy depositors

Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...

and

Alfred P. Sloan, Jr. Prize The Alfred P. Sloan Jr. Prize was a $250,000 award given by the General Motors Cancer Research Foundation for outstanding oncological research. The prize was awarded annually from 1979 to 2005. Of the winners, 15 out of 37 have gone on to win eit ...

winner J. Michael Bishop deposited the anti c-MYC hybridoma 9e 10

winner Sir John Gurdon deposited MyoD clone D7F2 Nobel Prize winner

Eric F. Wieschaus Eric Francis Wieschaus (born June 8, 1947 in South Bend, Indiana) is an American evolutionary developmental biologist and 1995 Nobel Prize-winner. Early life Born in South Bend, Indiana, he attended John Carroll Catholic High School in Birming ...

deposited 7 hybridomas

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

Members who have deposited hybridomas :* Utpal Banerjee (1 hybridoma deposit)

University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public university, public Land-grant university, land-grant research university in Los Angeles, California, United States. Its academic roots were established in 1881 as a normal school the ...

:* Philip A. Beachy (5 hybridoma deposits)

Stanford University Leland Stanford Junior University, commonly referred to as Stanford University, is a Private university, private research university in Stanford, California, United States. It was founded in 1885 by railroad magnate Leland Stanford (the eighth ...

Seymour Benzer Seymour Benzer (October 15, 1921 – November 30, 2007) was an American physicist, molecular biologist and behavioral geneticist. His career began during the molecular biology revolution of the 1950s, and he eventually rose to prominence in the ...

(7 hybridoma deposits)

California Institute of Technology The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...

:* J. Michael Bishop (1 hybridoma deposits)

University of California, San Francisco The University of California, San Francisco (UCSF) is a Public university, public Land-grant university, land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedic ...

:* Helen Blau (11 hybridoma deposits)

:* Kevin P. Campbell (9 hybridoma deposits)

The University of Iowa The University of Iowa (U of I, UIowa, or Iowa) is a public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is organized into 12 colleges offer ...

:* Constance L. Cepko (1 hybridoma deposit)

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

:* Max Cooper (1 hybridoma deposit)

Emory University Emory University is a private university, private research university in Atlanta, Georgia, United States. It was founded in 1836 as Emory College by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory. Its main campu ...

:* Marilyn Gist Farquhar (1 hybridoma deposit)

University of California, San Diego The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Es ...

:* John Gurdon (1 hybridoma deposit)

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

:*Corey S. Goodman (25 hybridoma deposits)

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...

:* Thomas M. Jessell (36 hybridoma deposits)

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

Robb Krumlauf Robb Krumlauf is an American developmental biologist. He is best known for researching the Hox family of transcription factors. He is most interested in understanding the role of the Hox genes in the hindbrain and their role in areas of animal de ...

(1 hybridoma deposit)

Stowers Institute for Medical Research The Stowers Institute for Medical Research is an independently operated, non-profit organization focused on foundational biological research, based in Kansas City, Missouri. The institute is home to Principal Investigator labs and core Techn ...

:* N. M. Le Douarin (6 hybridoma deposits)

CNRS The French National Centre for Scientific Research (, , CNRS) is the French state research organisation and is the largest fundamental science agency in Europe. In 2016, it employed 31,637 staff, including 11,137 tenured researchers, 13,415 eng ...

Institute of Embryology :* Gerald M. Rubin (20 hybridoma deposits) HHMI / Janelia Research Campus :* Joshua R. Sanes (11 hybridoma deposits)

:* S. J. Singer (1 hybridoma deposit)

:* Roeland Nusse (2 hybridoma deposits)

:* Gertrud Schupbach (10 hybridoma deposits)

Princeton University Princeton University is a private university, private Ivy League research university in Princeton, New Jersey, United States. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial ...

:* Timothy A. Springer (7 hybridoma deposits)

Masatoshi Takeichi is a Japanese cell biologist known for his identification of the cadherin class of adhesion molecules, which plays important roles in the construction of tissues. He shared the 2005 Japan Prize with Erkki Ruoslahti for "fundamental contributio ...

(7 hybridoma deposits)

RIKEN is a national scientific research institute in Japan. Founded in 1917, it now has about 3,000 scientists on seven campuses across Japan, including the main site at Wakō, Saitama, Wakō, Saitama Prefecture, on the outskirts of Tokyo. Riken is a ...

:* Stephen T. Warren (1 hybridoma deposit)

Zena Werb Zena Werb (24 March 1945 – 16 June 2020) was a professor and the Vice Chair of Anatomy at the University of California, San Francisco. She was also the co-leader of the Cancer, Immunity, and Microenvironment Program at the Hellen Diller Family ...

(1 hybridoma deposit)

(7 hybridoma deposits)

References

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External links

Developmental Studies Hybridoma Bank
Developmental biology