David J. States is an American biophysicist who is professor of human genetics at the

University of Michigan The University of Michigan (U-M, U of M, or Michigan) is a public university, public research university in Ann Arbor, Michigan, United States. Founded in 1817, it is the oldest institution of higher education in the state. The University of Mi ...

. His research group is using computational methods to understand the human genome and how it relates to the human

proteome A proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. P ...

. He is the director of the Michigan NIH Bioinformatics Training Program and a senior scientist in the National Center for Integrative Biomedical Informatics.

Early life and education

States earned his B.A. ('75), M.D. ('83) and Ph.D. ('83) degrees at

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

Career

He was a staff scientist at the National Magnet Laboratory at MIT and a resident in internal medicine at

UCSD Medical Center The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public land-grant research university in San Diego, California, United States. Established in 1960 near the pre-existing Sc ...

. He then moved to the NIH as a clinical associate and senior staff fellow, where he joined the National Center for Biotechnology Information (NCBI). While at NCBI, he and Warren Gish enhanced

BLAST Blast or The Blast may refer to: *Explosion, a rapid increase in volume and release of energy in an extreme manner *Detonation, an exothermic front accelerating through a medium that eventually drives a shock front *A planned explosion in a mine, ...

, one of the most widely used programs in bioinformatics In 1992, States was recruited to Washington University as director of the Institute for Biomedical Computing, and in 2001, he moved to the University of Michigan to establish the University of Michigan Bioinformatics Program. He was a member of the founding board of directors and treasurer of the International Society for Computational Biology and Chair of the 2005 Intelligent Systems for Molecular Biology Conferences. States is also known for his work in

nuclear magnetic resonance Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are disturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a ...

where he developed pure absorption phase multi-dimensional spectroscopy, a technique now widely used in protein structure determination. States also contributed to computational biophysics as an author of the

CHARMM Chemistry at Harvard Macromolecular Mechanics (CHARMM) is the name of a widely used set of force fields for molecular dynamics, and the name for the molecular dynamics simulation and analysis computer software package associated with them. The CH ...

molecular dynamics simulation program. He combined NMR spectroscopy and modeling to demonstrate for the first time the presence of native-like structure in the folding intermediates of bovine pancreatic trypsin inhibitor -2and the first demonstration of a conformationally trapped folding intermediate

Publications

* States DJ, Creighton TE, Dobson CM, Karplus M. Conformations of intermediates in the folding of the pancreatic trypsin inhibitor. Journal of Molecular Biology. 1987 195(3):731-9. * States DJ, Dobson CM, Karplus M. A new two-disulphide intermediate in the refolding of reduced bovine pancreatic trypsin inhibitor. Journal of Molecular Biology. 1984 174(2):411-8. *States DJ, Dobson CM, Karplus M, Creighton TE. A conformational isomer of bovine pancreatic trypsin inhibitor protein produced by refolding. Nature. 1980 286(5773):630-2. *Gish W, States DJ. Identification of protein coding regions by database similarity search. Nature Genetics. 1993 3(3):266-72.

External links

States lab

National Center for Integrative Biomedical Informatics

Michigan Bioinformatics Program
{{DEFAULTSORT:States, David American biophysicists American bioinformaticians Harvard Medical School alumni Living people Proteomics University of Michigan faculty Year of birth missing (living people)