Segment polarity protein dishevelled homolog DVL-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''DVL1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
DVL1, the human homolog of the ''Drosophila''
dishevelled gene (dsh), encodes a cytoplasmic
phosphoprotein
A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonin ...
that regulates
cell proliferation
Cell proliferation is the process by which ''a cell grows and divides to produce two daughter cells''. Cell proliferation leads to an exponential increase in cell number and is therefore a rapid mechanism of tissue growth. Cell proliferation ...
, acting as a transducer molecule for developmental processes, including segmentation and
neuroblast specification. DVL1 is a candidate gene for processes involved in cell transformations involved in
neuroblastoma. The
Schwartz–Jampel syndrome and
Charcot–Marie–Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
Interactions
DVL1 has been shown to
interact with:
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AXIN1,
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DVL3,
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EPS8,
and
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Mothers against decapentaplegic homolog 3.
See also
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Dishevelled
References
Further reading
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External links
DVL1on the
Atlas of Genetics and Oncology
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