Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''DLGAP1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the
post-synaptic density.
Function
This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the
SHANK2 and
PSD-95 proteins, facilitating the assembly of the post-synaptic density of neurons.
Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.
Interactions
DLGAP1 has been shown to
interact with:
*
DLG1[
* DLG4][
* DYNLL2][
* SHANK2][
The interaction with PSD95 and S-SCAM is mediated by the GUK domain]
References
Further reading
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{{gene-18-stub
Proteins