Cannabis
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''Cannabis'' () is a
genus Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus com ...
of
flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...
s in the family
Cannabaceae Cannabaceae is a small family of flowering plants, known as the hemp family. As now circumscribed, the family includes about 170 species grouped in about 11 genera, including ''Cannabis'' (hemp), '' Humulus'' (hops) and '' Celtis'' (hackberries ...
. The number of species within the genus is disputed. Three species may be recognized: ''
Cannabis sativa ''Cannabis sativa'' is an annual herbaceous flowering plant indigenous to Eastern Asia, but now of cosmopolitan distribution due to widespread cultivation. It has been cultivated throughout recorded history, used as a source of industrial fibe ...
'', '' C. indica'', and '' C. ruderalis''. Alternatively, ''C. ruderalis'' may be included within ''C. sativa'', all three may be treated as
subspecies In biological classification, subspecies is a rank below species, used for populations that live in different areas and vary in size, shape, or other physical characteristics (morphology), but that can successfully interbreed. Not all species ...
of ''C. sativa'', or ''C. sativa'' may be accepted as a single undivided species. The genus is widely accepted as being
indigenous Indigenous may refer to: *Indigenous peoples *Indigenous (ecology), presence in a region as the result of only natural processes, with no human intervention *Indigenous (band), an American blues-rock band *Indigenous (horse), a Hong Kong racehorse ...
to and originating from
Asia Asia (, ) is one of the world's most notable geographical regions, which is either considered a continent in its own right or a subcontinent of Eurasia, which shares the continental landmass of Afro-Eurasia with Africa. Asia covers an area ...
. The plant is also known as
hemp Hemp, or industrial hemp, is a botanical class of ''Cannabis sativa'' cultivars grown specifically for industrial or medicinal use. It can be used to make a wide range of products. Along with bamboo, hemp is among the fastest growing plants o ...
, although this term is often used to refer only to
varieties Variety may refer to: Arts and entertainment Entertainment formats * Variety (radio) * Variety show, in theater and television Films * ''Variety'' (1925 film), a German silent film directed by Ewald Andre Dupont * ''Variety'' (1935 film), ...
of ''Cannabis'' cultivated for non-drug use. Cannabis has long been used for hemp fibre,
hemp seed Hemp, or industrial hemp, is a botanical class of ''Cannabis sativa'' cultivars grown specifically for industrial or medicinal use. It can be used to make a wide range of products. Along with bamboo, hemp is among the fastest growing plants o ...
s and their
oils An oil is any nonpolar chemical substance that is composed primarily of hydrocarbons and is hydrophobic (does not mix with water) & lipophilic (mixes with other oils). Oils are usually flammable and surface active. Most oils are unsaturate ...
, hemp
leaves A leaf (plural, : leaves) is any of the principal appendages of a vascular plant plant stem, stem, usually borne laterally aboveground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", wh ...
for use as
vegetables Vegetables are parts of plants that are consumed by humans or other animals as food. The original meaning is still commonly used and is applied to plants collectively to refer to all edible plant matter, including the flowers, fruits, stems, ...
and as
juice Juice is a drink made from the extraction or pressing of the natural liquid contained in fruit and vegetables. It can also refer to liquids that are flavored with concentrate or other biological food sources, such as meat or seafood, such as ...
,
medicinal purposes ''Medicinal Purposes'' is a Big Finish Productions audio drama based on the long-running British science fiction television series ''Doctor Who''. Plot Edinburgh, 1827. Body snatchers William Burke and William Hare are on the loose while the ...
, and as a recreational drug. Industrial hemp products are made from cannabis plants selected to produce an abundance of fibre. Various cannabis strains have been bred, often selectively to produce high or low levels of
tetrahydrocannabinol Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC' ...
(THC), a
cannabinoid Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...
and the plant's principal psychoactive constituent. Compounds such as hashish and
hash oil Hash oil or cannabis oil, is an oleoresin obtained by the extraction of cannabis or hashish. It is a cannabis concentrate containing many of its resins and terpenes – in particular, tetrahydrocannabinol (THC), cannabidiol (CBD), and other ...
are extracted from the plant.Erowid. 2006
Cannabis Basics
. Retrieved on 25 February 2007


Description

Cannabis is an
annual Annual may refer to: *Annual publication, periodical publications appearing regularly once per year ** Yearbook ** Literary annual *Annual plant *Annual report *Annual giving *Annual, Morocco, a settlement in northeastern Morocco *Annuals (band), ...
,
dioecious Dioecy (; ; adj. dioecious , ) is a characteristic of a species, meaning that it has distinct individual organisms (unisexual) that produce male or female gametes, either directly (in animals) or indirectly (in seed plants). Dioecious reproductio ...
,
flowering A flower, sometimes known as a bloom or blossom, is the reproductive structure found in flowering plants (plants of the division Angiospermae). The biological function of a flower is to facilitate reproduction, usually by providing a mechanism ...
herb In general use, herbs are a widely distributed and widespread group of plants, excluding vegetables and other plants consumed for macronutrients, with savory or aromatic properties that are used for flavoring and garnishing food, for medicinal ...
. The
leaves A leaf (plural, : leaves) is any of the principal appendages of a vascular plant plant stem, stem, usually borne laterally aboveground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", wh ...
are palmately compound or digitate, with
serrate Serration is a saw-like appearance or a row of sharp or tooth-like projections. A serrated cutting edge has many small points of contact with the material being cut. By having less contact area than a smooth blade or other edge, the applied p ...
leaflets. The first pair of leaves usually have a single leaflet, the number gradually increasing up to a maximum of about thirteen leaflets per leaf (usually seven or nine), depending on
variety Variety may refer to: Arts and entertainment Entertainment formats * Variety (radio) * Variety show, in theater and television Films * ''Variety'' (1925 film), a German silent film directed by Ewald Andre Dupont * ''Variety'' (1935 film), ...
and growing conditions. At the top of a flowering plant, this number again diminishes to a single leaflet per leaf. The lower leaf pairs usually occur in an opposite
leaf arrangement In botany, phyllotaxis () or phyllotaxy is the arrangement of leaves on a plant stem. Phyllotactic spirals form a distinctive class of patterns in nature. Leaf arrangement The basic arrangements of leaves on a stem are opposite and alterna ...
and the upper leaf pairs in an alternate arrangement on the main stem of a mature plant. The leaves have a peculiar and diagnostic venation pattern (which varies slightly among varieties) that allows for easy identification of cannabis leaves from unrelated species with similar leaves. As is common in serrated leaves, each serration has a central vein extending to its tip, but in cannabis this originates from lower down the central vein of the leaflet, typically opposite to the position of the second notch down. This means that on its way from the midrib of the leaflet to the point of the serration, the vein serving the tip of the serration passes close by the intervening notch. Sometimes the vein will pass tangentially to the notch, but often will pass by at a small distance; when the latter happens a spur vein (or occasionally two) branches off and joins the leaf margin at the deepest point of the notch. Tiny samples of ''Cannabis'' also can be identified with precision by microscopic examination of leaf cells and similar features, requiring special equipment and expertise.


Reproduction

All known strains of ''Cannabis'' are
wind-pollinated Anemophily or wind pollination is a form of pollination whereby pollen is distributed by wind. Almost all gymnosperms are anemophilous, as are many plants in the order Poales, including grasses, sedges, and rushes. Other common anemophilous pla ...
and the fruit is an
achene An achene (; ), also sometimes called akene and occasionally achenium or achenocarp, is a type of simple dry fruit produced by many species of flowering plants. Achenes are monocarpellate (formed from one carpel) and indehiscent (they do not ope ...
. Most strains of ''Cannabis'' are short day plants, with the possible exception of ''C. sativa'' subsp. ''sativa'' var. ''spontanea'' (= ''C. ruderalis''), which is commonly described as "auto-flowering" and may be day-neutral. ''Cannabis'' is predominantly dioecious, having
imperfect The imperfect ( abbreviated ) is a verb form that combines past tense (reference to a past time) and imperfective aspect (reference to a continuing or repeated event or state). It can have meanings similar to the English "was walking" or "used to ...
flowers A flower, sometimes known as a bloom or blossom, is the reproductive structure found in flowering plants (plants of the division Angiospermae). The biological function of a flower is to facilitate reproduction, usually by providing a mechanism ...
, with
staminate The stamen (plural ''stamina'' or ''stamens'') is the pollen-producing reproductive organ of a flower. Collectively the stamens form the androecium., p. 10 Morphology and terminology A stamen typically consists of a stalk called the filame ...
"male" and pistillate "female" flowers occurring on separate plants. "At a very early period the Chinese recognized the ''Cannabis'' plant as dioecious", and the (c. 3rd century BCE) '' Erya'' dictionary defined ''xi'' "male ''Cannabis''" and ''fu'' (or ''ju'' ) "female ''Cannabis''". Male flowers are normally borne on loose panicles, and female flowers are borne on racemes.Bouquet, R. J. 1950
''Cannabis''
United Nations Office on Drugs and Crime The United Nations Office on Drugs and Crime (UNODC; French: ''Office des Nations unies contre la drogue et le crime'') is a United Nations office that was established in 1997 as the Office for Drug Control and Crime Prevention by combining the ...
. Retrieved on 23 February 2007
Many monoecious varieties have also been described, in which individual plants bear both male and female flowers. (Although monoecious plants are often referred to as "hermaphrodites", true hermaphrodites – which are less common in ''Cannabis'' – bear staminate and pistillate structures together on individual flowers, whereas monoecious plants bear male and female flowers at different locations on the same plant.) Subdioecy (the occurrence of monoecious individuals and dioecious individuals within the same population) is widespread. Many populations have been described as sexually labile. As a result of intensive selection in cultivation, ''Cannabis'' exhibits many sexual phenotypes that can be described in terms of the ratio of female to male flowers occurring in the individual, or typical in the cultivar. Dioecious varieties are preferred for drug production, where the fruits (produced by female flowers) are used. Dioecious varieties are also preferred for textile fiber production, whereas monoecious varieties are preferred for pulp and paper production. It has been suggested that the presence of monoecy can be used to differentiate licit crops of monoecious hemp from illicit drug crops, but ''sativa'' strains often produce monoecious individuals, which is possibly as a result of
inbreeding Inbreeding is the production of offspring from the mating or breeding of individuals or organisms that are closely related genetically. By analogy, the term is used in human reproduction, but more commonly refers to the genetic disorders and o ...
.


Sex determination

''Cannabis'' has been described as having one of the most complicated mechanisms of sex determination among the dioecious plants. Many models have been proposed to explain sex determination in ''Cannabis''. Based on studies of sex reversal in
hemp Hemp, or industrial hemp, is a botanical class of ''Cannabis sativa'' cultivars grown specifically for industrial or medicinal use. It can be used to make a wide range of products. Along with bamboo, hemp is among the fastest growing plants o ...
, it was first reported by K. Hirata in 1924 that an
XY sex-determination system The XY sex-determination system is a sex-determination system used to classify many mammals, including humans, some insects (''Drosophila''), some snakes, some fish ( guppies), and some plants ('' Ginkgo'' tree). In this system, the sex of an i ...
is present. At the time, the XY system was the only known system of sex determination. The X:A system was first described in Drosophila spp in 1925. Soon thereafter, Schaffner disputed Hirata's interpretation, and published results from his own studies of sex reversal in hemp, concluding that an X:A system was in use and that furthermore sex was strongly influenced by environmental conditions. Since then, many different types of sex determination systems have been discovered, particularly in plants. Dioecy is relatively uncommon in the plant kingdom, and a very low percentage of dioecious plant species have been determined to use the XY system. In most cases where the XY system is found it is believed to have evolved recently and independently. Since the 1920s, a number of sex determination models have been proposed for ''Cannabis''. Ainsworth describes sex determination in the genus as using "an X/autosome dosage type". The question of whether heteromorphic
sex chromosomes A sex chromosome (also referred to as an allosome, heterotypical chromosome, gonosome, heterochromosome, or idiochromosome) is a chromosome that differs from an ordinary autosome in form, size, and behavior. The human sex chromosomes, a typical ...
are indeed present is most conveniently answered if such chromosomes were clearly visible in a karyotype. ''Cannabis'' was one of the first plant species to be karyotyped; however, this was in a period when karyotype preparation was primitive by modern standards. Heteromorphic sex chromosomes were reported to occur in staminate individuals of dioecious "Kentucky" hemp, but were not found in pistillate individuals of the same variety. Dioecious "Kentucky" hemp was assumed to use an XY mechanism. Heterosomes were not observed in analyzed individuals of monoecious "Kentucky" hemp, nor in an unidentified German cultivar. These varieties were assumed to have sex chromosome composition XX. According to other researchers, no modern karyotype of ''Cannabis'' had been published as of 1996. Proponents of the XY system state that Y chromosome is slightly larger than the X, but difficult to differentiate cytologically. More recently, Sakamoto and various co-authors have used
random amplification of polymorphic DNA Random amplification of polymorphic DNA (RAPD), pronounced "rapid", is a type of polymerase chain reaction (PCR), but the segments of DNA that are amplified are random. The scientist performing RAPD creates several arbitrary, short primers (10- 1 ...
(RAPD) to isolate several
genetic marker A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be ...
sequences that they name Male-Associated DNA in ''Cannabis'' (MADC), and which they interpret as indirect evidence of a male chromosome. Several other research groups have reported identification of male-associated markers using RAPD and
amplified fragment length polymorphism AFLP-PCR or just AFLP is a PCR-based tool used in genetics research, DNA fingerprinting, and in the practice of genetic engineering. Developed in the early 1990s by KeyGene, AFLP uses restriction enzymes to digest genomic DNA, followed by liga ...
. Ainsworth commented on these findings, stating, Environmental sex determination is known to occur in a variety of species. Many researchers have suggested that sex in ''Cannabis'' is determined or strongly influenced by environmental factors. Ainsworth reviews that treatment with auxin and
ethylene Ethylene (IUPAC name: ethene) is a hydrocarbon which has the formula or . It is a colourless, flammable gas with a faint "sweet and musky" odour when pure. It is the simplest alkene (a hydrocarbon with carbon-carbon double bonds). Ethylene i ...
have feminizing effects, and that treatment with
cytokinins Cytokinins (CK) are a class of plant hormones that promote cell division, or cytokinesis, in plant roots and shoots. They are involved primarily in cell growth and differentiation, but also affect apical dominance, axillary bud growth, and le ...
and gibberellins have masculinizing effects. It has been reported that sex can be reversed in ''Cannabis'' using chemical treatment. A
polymerase chain reaction The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) ...
-based method for the detection of female-associated DNA polymorphisms by
genotyping Genotyping is the process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence. ...
has been developed. File:Hemp plants-cannabis sativa-single 3.JPG, A male hemp plant File:Cannabis indica Selkem.jpg, Dense raceme of female flowers typical of drug-type varieties of ''Cannabis''


Chemistry

''Cannabis'' plants produce a large number of chemicals as part of their defense against herbivory. One group of these is called
cannabinoid Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...
s, which induce mental and physical
effects Effect may refer to: * A result or change of something ** List of effects ** Cause and effect, an idiom describing causality Pharmacy and pharmacology * Drug effect, a change resulting from the administration of a drug ** Therapeutic effect, a ...
when consumed. Cannabinoids,
terpenoid The terpenoids, also known as isoprenoids, are a class of naturally occurring organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc. While sometimes used interchangeably with "terpenes" ...
s, and other compounds are secreted by glandular
trichome Trichomes (); ) are fine outgrowths or appendages on plants, algae, lichens, and certain protists. They are of diverse structure and function. Examples are hairs, glandular hairs, scales, and papillae. A covering of any kind of hair on a p ...
s that occur most abundantly on the floral calyxes and
bract In botany, a bract is a modified or specialized leaf, especially one associated with a reproductive structure such as a flower, inflorescence axis or cone scale. Bracts are usually different from foliage leaves. They may be smaller, larger, or of ...
s of female plants. File:Cannabis sativa radix profile.png, Root system side view File:Cannabis sativa radix topview.png, Root system top view File:Cannabis hemp sativa (left) indica (right).png, Micrograph ''C. sativa'' (left), ''C. indica'' (right)


Genetics

''Cannabis'', like many organisms, is
diploid Ploidy () is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes. Sets of chromosomes refer to the number of maternal and paternal chromosome copies, respectively ...
, having a
chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...
complement of 2n=20, although
polyploid Polyploidy is a condition in which the cells of an organism have more than one pair of ( homologous) chromosomes. Most species whose cells have nuclei ( eukaryotes) are diploid, meaning they have two sets of chromosomes, where each set contain ...
individuals have been artificially produced. The first genome sequence of ''Cannabis'', which is estimated to be 820 Mb in size, was published in 2011 by a team of Canadian scientists.


Taxonomy

The genus ''Cannabis'' was formerly placed in the
nettle {{redirect, Nettle Nettle refers to plants with stinging hairs, particularly those of the genus '' Urtica''. It can also refer to plants which resemble ''Urtica'' species in appearance but do not have stinging hairs. Plants called "nettle" includ ...
family (
Urticaceae The Urticaceae are a family, the nettle family, of flowering plants. The family name comes from the genus ''Urtica''. The Urticaceae include a number of well-known and useful plants, including nettles in the genus ''Urtica'', ramie (''Boehmeri ...
) or
mulberry ''Morus'', a genus of flowering plants in the family Moraceae, consists of diverse species of deciduous trees commonly known as mulberries, growing wild and under cultivation in many temperate world regions. Generally, the genus has 64 identif ...
family (
Moraceae The Moraceae — often called the mulberry family or fig family — are a family of flowering plants comprising about 38 genera and over 1100 species. Most are widespread in tropical and subtropical regions, less so in temperate climates; however ...
), and later, along with the genus ''
Humulus ''Humulus'', hop, is a small genus of flowering plants in the family Cannabaceae. The hop is native to temperate regions of the Northern Hemisphere. Hops are the female flowers (seed cones, strobiles) of the hop species '' H. lupulus''; as a main ...
'' ( hops), in a separate family, the hemp family (Cannabaceae sensu stricto). Recent
phylogenetic In biology, phylogenetics (; from Greek φυλή/ φῦλον [] "tribe, clan, race", and wikt:γενετικός, γενετικός [] "origin, source, birth") is the study of the evolutionary history and relationships among or within groups o ...
studies based on
cpDNA Chloroplast DNA (cpDNA) is the DNA located in chloroplasts, which are photosynthetic organelles located within the cells of some eukaryotic organisms. Chloroplasts, like other types of plastid, contain a genome separate from that in the cell nuc ...
restriction site Restriction sites, or restriction recognition sites, are located on a DNA molecule containing specific (4-8 base pairs in length) sequences of nucleotides, which are recognized by restriction enzymes. These are generally palindromic sequences (bec ...
analysis and gene sequencing strongly suggest that the Cannabaceae sensu stricto arose from within the former family Celtidaceae, and that the two families should be merged to form a single
monophyletic In cladistics for a group of organisms, monophyly is the condition of being a clade—that is, a group of taxa composed only of a common ancestor (or more precisely an ancestral population) and all of its lineal descendants. Monophyletic gro ...
family, the
Cannabaceae Cannabaceae is a small family of flowering plants, known as the hemp family. As now circumscribed, the family includes about 170 species grouped in about 11 genera, including ''Cannabis'' (hemp), '' Humulus'' (hops) and '' Celtis'' (hackberries ...
sensu lato ''Sensu'' is a Latin word meaning "in the sense of". It is used in a number of fields including biology, geology, linguistics, semiotics, and law. Commonly it refers to how strictly or loosely an expression is used in describing any particular c ...
. Various types of ''Cannabis'' have been described, and variously classified as
species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...
,
subspecies In biological classification, subspecies is a rank below species, used for populations that live in different areas and vary in size, shape, or other physical characteristics (morphology), but that can successfully interbreed. Not all species ...
, or
varieties Variety may refer to: Arts and entertainment Entertainment formats * Variety (radio) * Variety show, in theater and television Films * ''Variety'' (1925 film), a German silent film directed by Ewald Andre Dupont * ''Variety'' (1935 film), ...
: * plants cultivated for fiber and seed production, described as low-intoxicant, non-drug, or fiber types. * plants cultivated for drug production, described as high-intoxicant or drug types. * escaped, hybridised, or wild forms of either of the above types. ''Cannabis'' plants produce a unique family of terpeno-phenolic compounds called cannabinoids, some of which produce the "high" which may be experienced from consuming marijuana. There are 483 identifiable chemical constituents known to exist in the cannabis plant, and at least 85 different cannabinoids have been isolated from the plant. The two cannabinoids usually produced in greatest abundance are
cannabidiol Cannabidiol (CBD) is a phytocannabinoid discovered in 1940. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. , clinical research on CBD incl ...
(CBD) and/or Δ9-
tetrahydrocannabinol Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC' ...
(THC), but only THC is psychoactive. Since the early 1970s, ''Cannabis'' plants have been categorized by their chemical
phenotype In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...
or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD. Although overall cannabinoid production is influenced by environmental factors, the THC/CBD ratio is genetically determined and remains fixed throughout the life of a plant. Non-drug plants produce relatively low levels of THC and high levels of CBD, while drug plants produce high levels of THC and low levels of CBD. When plants of these two chemotypes cross-pollinate, the plants in the first filial (F1) generation have an intermediate chemotype and produce intermediate amounts of CBD and THC. Female plants of this chemotype may produce enough THC to be utilized for drug production. Whether the drug and non-drug, cultivated and wild types of ''Cannabis'' constitute a single, highly variable species, or the genus is polytypic with more than one species, has been a subject of debate for well over two centuries. This is a contentious issue because there is no universally accepted definition of a
species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...
. One widely applied criterion for species recognition is that species are "groups of actually or potentially interbreeding natural populations which are reproductively isolated from other such groups." Populations that are physiologically capable of interbreeding, but morphologically or genetically divergent and isolated by geography or ecology, are sometimes considered to be separate species. Physiological barriers to reproduction are not known to occur within ''Cannabis'', and plants from widely divergent sources are interfertile. However, physical barriers to gene exchange (such as the Himalayan mountain range) might have enabled ''Cannabis'' gene pools to diverge before the onset of human intervention, resulting in speciation. It remains controversial whether sufficient morphological and genetic divergence occurs within the genus as a result of geographical or ecological isolation to justify recognition of more than one species.


Early classifications

The genus ''Cannabis'' was first classified using the "modern" system of taxonomic
nomenclature Nomenclature (, ) is a system of names or terms, or the rules for forming these terms in a particular field of arts or sciences. The principles of naming vary from the relatively informal naming conventions, conventions of everyday speech to the i ...
by
Carl Linnaeus Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the ...
in 1753, who devised the system still in use for the naming of species. He considered the genus to be monotypic, having just a single species that he named ''Cannabis sativa'' L. (L. stands for Linnaeus, and indicates the authority who first named the species). Linnaeus was familiar with European hemp, which was widely cultivated at the time. In 1785, noted evolutionary biologist
Jean-Baptiste de Lamarck Jean-Baptiste Pierre Antoine de Monet, chevalier de Lamarck (1 August 1744 – 18 December 1829), often known simply as Lamarck (; ), was a French naturalist, biologist, academic, and soldier. He was an early proponent of the idea that biolog ...
published a description of a second species of ''Cannabis'', which he named ''Cannabis indica'' Lam. Lamarck based his description of the newly named species on plant specimens collected in India. He described ''C. indica'' as having poorer fiber quality than ''C. sativa'', but greater utility as an inebriant. Additional ''Cannabis'' species were proposed in the 19th century, including strains from China and Vietnam (Indo-China) assigned the names ''Cannabis chinensis'' Delile, and ''Cannabis gigantea'' Delile ex Vilmorin. However, many taxonomists found these putative species difficult to distinguish. In the early 20th century, the single-species concept was still widely accepted, except in the
Soviet Union The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen national ...
where ''Cannabis'' continued to be the subject of active taxonomic study. The name ''Cannabis indica'' was listed in various
Pharmacopoeia A pharmacopoeia, pharmacopeia, or pharmacopoea (from the obsolete typography ''pharmacopœia'', meaning "drug-making"), in its modern technical sense, is a book containing directions for the identification of compound medicines, and published by ...
s, and was widely used to designate ''Cannabis'' suitable for the manufacture of medicinal preparations.


20th century

In 1924, Russian botanist D.E. Janichevsky concluded that
ruderal A ruderal species is a plant species that is first to colonize disturbed lands. The disturbance may be natural for example, wildfires or avalanchesor the consequences of human activities, such as construction ( of roads, of buildings, mining, et ...
''Cannabis'' in central Russia is either a variety of ''C. sativa'' or a separate species, and proposed ''C. sativa'' L. var. ''ruderalis'' Janisch, and ''Cannabis ruderalis'' Janisch, as alternative names. In 1929, renowned plant explorer
Nikolai Vavilov Nikolai Ivanovich Vavilov ( rus, Никола́й Ива́нович Вави́лов, p=nʲɪkɐˈlaj ɪˈvanəvʲɪtɕ vɐˈvʲiləf, a=Ru-Nikolay_Ivanovich_Vavilov.ogg; – 26 January 1943) was a Russian and Soviet agronomist, botanist a ...
assigned wild or feral populations of ''Cannabis'' in Afghanistan to ''C. indica'' Lam. var. ''kafiristanica'' Vav., and ruderal populations in Europe to ''C. sativa'' L. var. ''spontanea'' Vav. In 1940, Russian botanists Serebriakova and Sizov proposed a complex classification in which they also recognized ''C. sativa'' and ''C. indica'' as separate species. Within ''C. sativa'' they recognized two subspecies: ''C. sativa'' L. subsp. ''culta'' Serebr. (consisting of cultivated plants), and ''C. sativa'' L. subsp. ''spontanea'' (Vav.) Serebr. (consisting of wild or feral plants). Serebriakova and Sizov split the two ''C. sativa'' subspecies into 13 varieties, including four distinct groups within subspecies ''culta''. However, they did not divide ''C. indica'' into subspecies or varieties. In the 1970s, the taxonomic classification of ''Cannabis'' took on added significance in North America. Laws prohibiting ''Cannabis'' in the
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
and
Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tot ...
specifically named products of ''C. sativa'' as prohibited materials. Enterprising attorneys for the defense in a few drug busts argued that the seized ''Cannabis'' material may not have been ''C. sativa'', and was therefore not prohibited by law. Attorneys on both sides recruited botanists to provide expert testimony. Among those testifying for the prosecution was Dr. Ernest Small, while Dr. Richard E. Schultes and others testified for the defense. The botanists engaged in heated debate (outside of court), and both camps impugned the other's integrity. The defense attorneys were not often successful in winning their case, because the intent of the law was clear. In 1976, Canadian botanist Ernest SmallErnest Small (biography)
. National Research Council Canada. Retrieved on 23 February 2007
and American taxonomist
Arthur Cronquist Arthur John Cronquist (March 19, 1919 – March 22, 1992) was an American biologist, botanist and a specialist on Compositae. He is considered one of the most influential botanists of the 20th century, largely due to his formulation of the Cr ...
published a taxonomic revision that recognizes a single species of ''Cannabis'' with two subspecies and two varieties in each. The framework is thus: * ''C. sativa'' L. subsp. ''sativa'', presumably selected for traits that enhance fiber or seed production. ** ''C. sativa'' L. subsp. ''sativa'' var. ''sativa'', domesticated variety. ** ''C. sativa'' L. subsp. ''sativa'' var. ''spontanea'' Vav., wild or escaped variety. * ''C. sativa'' L. subsp. ''indica'' (Lam.) Small & Cronq., primarily selected for drug production. ** ''C. sativa'' L. subsp. ''indica'' var. ''indica'', domesticated variety. ** ''C. sativa'' subsp. ''indica'' var. ''kafiristanica'' (Vav.) Small & Cronq, wild or escaped variety. This classification was based on several factors including interfertility, chromosome uniformity, chemotype, and numerical analysis of
phenotypic In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...
characters. Professors William Emboden, Loran Anderson, and Harvard botanist
Richard E. Schultes Richard Evans Schultes (''SHULL-tees'';Jonathan Kandell ''The New York Times'', April 13, 2001, Accessed April 26, 2020. January 12, 1915 – April 10, 2001) was an American biologist. He may be considered the father of modern ethnobotany. He is ...
and coworkers also conducted taxonomic studies of ''Cannabis'' in the 1970s, and concluded that stable morphological differences exist that support recognition of at least three species, ''C. sativa'', ''C. indica'', and ''C. ruderalis.''Anderson, L. C.
1974. A study of systematic wood anatomy in ''Cannabis''. ''Harvard University Botanical Museum Leaflets'' 24: 29–36. Retrieved on 23 February 2007
Anderson, L. C.
1980. Leaf variation among ''Cannabis'' species from a controlled garden. ''Harvard University Botanical Museum Leaflets'' 28: 61–69. Retrieved on 23 February 2007
For Schultes, this was a reversal of his previous interpretation that ''Cannabis'' is monotypic, with only a single species. According to Schultes' and Anderson's descriptions, ''C. sativa'' is tall and laxly branched with relatively narrow leaflets, ''C. indica'' is shorter, conical in shape, and has relatively wide leaflets, and ''C. ruderalis'' is short, branchless, and grows wild in
Central Asia Central Asia, also known as Middle Asia, is a subregion, region of Asia that stretches from the Caspian Sea in the west to western China and Mongolia in the east, and from Afghanistan and Iran in the south to Russia in the north. It includes t ...
. This taxonomic interpretation was embraced by ''Cannabis'' aficionados who commonly distinguish narrow-leafed "sativa" strains from wide-leafed "indica" strains.Interview with Robert Connell Clarke
1 January 2005. NORML, New Zealand. Retrieved on 19 February 2007
McPartland's review finds the Schultes taxonomy inconsistent with prior work (protologs) and partly responsible for the popular usage.


Continuing research

Molecular analytical techniques developed in the late 20th century are being applied to questions of taxonomic classification. This has resulted in many reclassifications based on
evolutionary systematics Evolutionary taxonomy, evolutionary systematics or Darwinian classification is a branch of biological classification that seeks to classify organisms using a combination of phylogenetic relationship (shared descent), progenitor-descendant relati ...
. Several studies of
random amplified polymorphic DNA Random amplification of polymorphic DNA (RAPD), pronounced "rapid", is a type of polymerase chain reaction (PCR), but the segments of DNA that are amplified are random. The scientist performing RAPD creates several arbitrary, short primers (10- 1 ...
(RAPD) and other types of genetic markers have been conducted on drug and fiber strains of ''Cannabis'', primarily for plant breeding and forensic purposes. Dutch ''Cannabis'' researcher E.P.M. de Meijer and coworkers described some of their RAPD studies as showing an "extremely high" degree of genetic polymorphism between and within populations, suggesting a high degree of potential variation for selection, even in heavily selected hemp cultivars. They also commented that these analyses confirm the continuity of the ''Cannabis'' gene pool throughout the studied accessions, and provide further confirmation that the genus consists of a single species, although theirs was not a systematic study ''per se''. An investigation of genetic, morphological, and chemotaxonomic variation among 157 ''Cannabis'' accessions of known geographic origin, including fiber, drug, and feral populations showed cannabinoid variation in ''Cannabis''
germplasm Germplasm are living genetic resources such as seeds or tissues that are maintained for the purpose of animal and plant breeding, preservation, and other research uses. These resources may take the form of seed collections stored in seed banks, t ...
. The patterns of cannabinoid variation support recognition of ''C. sativa'' and ''C. indica'' as separate species, but not ''C. ruderalis''. ''C. sativa'' contains fiber and seed landraces, and feral populations, derived from Europe, Central Asia, and
Turkey Turkey ( tr, Türkiye ), officially the Republic of Türkiye ( tr, Türkiye Cumhuriyeti, links=no ), is a list of transcontinental countries, transcontinental country located mainly on the Anatolia, Anatolian Peninsula in Western Asia, with ...
. Narrow-leaflet and wide-leaflet drug accessions, southern and eastern Asian hemp accessions, and feral Himalayan populations were assigned to ''C. indica''. In 2005, a
genetic analysis Genetic analysis is the overall process of studying and researching in fields of science that involve genetics and molecular biology. There are a number of applications that are developed from this research, and these are also considered parts of ...
of the same set of accessions led to a three-species classification, recognizing ''C. sativa'', ''C. indica'', and (tentatively) ''C. ruderalis''. Another paper in the series on chemotaxonomic variation in the terpenoid content of the essential oil of ''Cannabis'' revealed that several wide-leaflet drug strains in the collection had relatively high levels of certain
sesquiterpene Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. Biochemical modificat ...
alcohols, including
guaiol Guaiol or champacol is an organic compound, a sesquiterpenoid alcohol found in several plants, especially in the oil of guaiacum and cypress pine.The Merriam-Webster Dictionary. It is a crystalline solid that melts at 92 ° C.Wolfram Alpha ''Guai ...
and isomers of eudesmol, that set them apart from the other putative taxa. An 2020 analysis of single-nucleotide polymorphisms reports five clusters of ''Cannabis'', roughly corresponding to hemps (including folk "Ruderalis"), folk "Indica", and folk "Sativa". Despite advanced analytical techniques, much of the cannabis used recreationally is inaccurately classified. One laboratory at the
University of British Columbia The University of British Columbia (UBC) is a public university, public research university with campuses near Vancouver and in Kelowna, British Columbia. Established in 1908, it is British Columbia's oldest university. The university ranks a ...
found that Jamaican Lamb's Bread, claimed to be 100% sativa, was in fact almost 100% indica (the opposite strain). Legalization of cannabis in Canada () may help spur private-sector research, especially in terms of diversification of strains. It should also improve classification accuracy for cannabis used recreationally. Legalization coupled with Canadian government (Health Canada) oversight of production and labelling will likely result in more—and more accurate—testing to determine exact strains and content. Furthermore, the rise of craft cannabis growers in Canada should ensure quality, experimentation/research, and diversification of strains among private-sector producers.


Popular usage

The scientific debate regarding taxonomy has had little effect on the terminology in widespread use among cultivators and users of drug-type ''Cannabis''. ''Cannabis'' aficionados recognize three distinct types based on such factors as morphology,
native range Species distribution —or species dispersion — is the manner in which a biological taxon is spatially arranged. The geographic limits of a particular taxon's distribution is its range, often represented as shaded areas on a map. Patterns of ...
, aroma, and subjective psychoactive characteristics. "Sativa" is the most widespread variety, which is usually tall, laxly branched, and found in warm lowland regions. "Indica" designates shorter, bushier plants adapted to cooler climates and highland environments. "Ruderalis" is the informal name for the short plants that grow wild in Europe and Central Asia. Mapping the morphological concepts to scientific names in the Small 1976 framework, "Sativa" generally refers to ''C. sativa'' subsp. ''indica'' var. ''indica'', "Indica" generally refers to ''C. sativa'' subsp. ''i.'' ''kafiristanica'' (also known as ''afghanica''), and "Ruderalis", being lower in THC, is the one that can fall into ''C. sativa'' subsp. ''sativa''. The three names fit in Schultes's framework better, if one overlooks its inconsistencies with prior work. Definitions of the three terms using factors other than morphology produces different, often conflicting results. Breeders, seed companies, and cultivators of drug type ''Cannabis'' often describe the ancestry or gross
phenotypic In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...
characteristics of
cultivar A cultivar is a type of cultivated plant that people have selected for desired traits and when propagated retain those traits. Methods used to propagate cultivars include: division, root and stem cuttings, offsets, grafting, tissue culture, ...
s by categorizing them as "pure indica", "mostly indica", "indica/sativa", "mostly sativa", or "pure sativa". These categories are highly arbitrary, however: one "AK-47" hybrid strain has received both "Best Sativa" and "Best Indica" awards.


Phylogeny

''Cannabis'' likely split from its closest relative, ''
Humulus ''Humulus'', hop, is a small genus of flowering plants in the family Cannabaceae. The hop is native to temperate regions of the Northern Hemisphere. Hops are the female flowers (seed cones, strobiles) of the hop species '' H. lupulus''; as a main ...
'' (hops), during the mid Oligocene, around 27.8 million years ago according to
molecular clock The molecular clock is a figurative term for a technique that uses the mutation rate of biomolecules to deduce the time in prehistory when two or more life forms diverged. The biomolecular data used for such calculations are usually nucleo ...
estimates. The centre of origin of ''Cannabis'' is likely in the northeastern
Tibetan Plateau The Tibetan Plateau (, also known as the Qinghai–Tibet Plateau or the Qing–Zang Plateau () or as the Himalayan Plateau in India, is a vast elevated plateau located at the intersection of Central, South and East Asia covering most of the Ti ...
. The pollen of ''Humulus'' and ''Cannabis'' are very similar and difficult to distinguish. The oldest pollen thought to be from ''Cannabis'' is from
Ningxia Ningxia (,; , ; alternately romanized as Ninghsia), officially the Ningxia Hui Autonomous Region (NHAR), is an autonomous region in the northwest of the People's Republic of China. Formerly a province, Ningxia was incorporated into Gansu in ...
, China, on the boundary between the Tibetan Plateau and the
Loess Plateau The Chinese Loess Plateau, or simply the Loess Plateau, is a plateau in north-central China formed of loess, a clastic silt-like sediment formed by the accumulation of wind-blown dust. It is located southeast of the Gobi Desert and is surrounde ...
, dating to the early
Miocene The Miocene ( ) is the first geological epoch of the Neogene Period and extends from about (Ma). The Miocene was named by Scottish geologist Charles Lyell; the name comes from the Greek words (', "less") and (', "new") and means "less recen ...
, around 19.6 million years ago. ''Cannabis'' was widely distributed over Asia by the Late Pleistocene. The oldest known ''Cannabis'' in South Asia dates to around 32,000 years ago.


Etymology

The word ''cannabis'' is from
Greek Greek may refer to: Greece Anything of, from, or related to Greece, a country in Southern Europe: *Greeks, an ethnic group. *Greek language, a branch of the Indo-European language family. **Proto-Greek language, the assumed last common ancestor ...
(') (see
Latin Latin (, or , ) is a classical language belonging to the Italic branch of the Indo-European languages. Latin was originally a dialect spoken in the lower Tiber area (then known as Latium) around present-day Rome, but through the power of the ...
'), which was originally
Scythian The Scythians or Scyths, and sometimes also referred to as the Classical Scythians and the Pontic Scythians, were an ancient Eastern * : "In modern scholarship the name 'Sakas' is reserved for the ancient tribes of northern and eastern Centra ...
or
Thracian The Thracians (; grc, Θρᾷκες ''Thrāikes''; la, Thraci) were an Indo-European speaking people who inhabited large parts of Eastern and Southeastern Europe in ancient history.. "The Thracians were an Indo-European people who occupied ...
. It is related to the
Persian Persian may refer to: * People and things from Iran, historically called ''Persia'' in the English language ** Persians, the majority ethnic group in Iran, not to be conflated with the Iranic peoples ** Persian language, an Iranian language of the ...
''kanab'', the English ''canvas'' and possibly the English ''
hemp Hemp, or industrial hemp, is a botanical class of ''Cannabis sativa'' cultivars grown specifically for industrial or medicinal use. It can be used to make a wide range of products. Along with bamboo, hemp is among the fastest growing plants o ...
'' (
Old English Old English (, ), or Anglo-Saxon, is the earliest recorded form of the English language, spoken in England and southern and eastern Scotland in the early Middle Ages. It was brought to Great Britain by Anglo-Saxon settlement of Britain, Anglo ...
').


Uses

''Cannabis'' is used for a wide variety of purposes.


History

According to genetic and archaeological evidence, cannabis was first domesticated about 12,000 years ago in
East Asia East Asia is the eastern region of Asia, which is defined in both geographical and ethno-cultural terms. The modern states of East Asia include China, Japan, Mongolia, North Korea, South Korea, and Taiwan. China, North Korea, South Korea and ...
during the early
Neolithic The Neolithic period, or New Stone Age, is an Old World archaeological period and the final division of the Stone Age. It saw the Neolithic Revolution, a wide-ranging set of developments that appear to have arisen independently in several parts ...
period. The use of cannabis as a mind-altering drug has been documented by archaeological finds in prehistoric societies in Eurasia and Africa. The oldest written record of cannabis usage is the Greek historian
Herodotus Herodotus ( ; grc, , }; BC) was an ancient Greek historian and geographer from the Greek city of Halicarnassus, part of the Persian Empire (now Bodrum, Turkey) and a later citizen of Thurii in modern Calabria ( Italy). He is known f ...
's reference to the central Eurasian
Scythians The Scythians or Scyths, and sometimes also referred to as the Classical Scythians and the Pontic Scythians, were an ancient Eastern * : "In modern scholarship the name 'Sakas' is reserved for the ancient tribes of northern and eastern Centra ...
taking cannabis steam baths. His () ''Histories'' records, "The Scythians, as I said, take some of this hemp-seed resumably, flowers and, creeping under the felt coverings, throw it upon the red-hot stones; immediately it smokes, and gives out such a vapour as no Greek vapour-bath can exceed; the Scyths, delighted, shout for joy." Classical Greeks and Romans also used cannabis. In China, the psychoactive properties of cannabis are described in the '' Shennong Bencaojing'' (3rd century AD). Cannabis smoke was inhaled by
Daoist Taoism (, ) or Daoism () refers to either a school of philosophical thought (道家; ''daojia'') or to a religion (道教; ''daojiao''), both of which share ideas and concepts of Chinese origin and emphasize living in harmony with the '' Tao ...
s, who burned it in incense burners. In the Middle East, use spread throughout the Islamic empire to North Africa. In 1545, cannabis spread to the western hemisphere where Spaniards imported it to Chile for its use as fiber. In North America, cannabis, in the form of hemp, was grown for use in rope, cloth and paper.
Cannabinol Cannabinol (CBN) is a mildly psychoactive cannabinoid that acts as a low affinity partial agonist at both CB1 and CB2 receptors. This activity at CB1 and CB2 receptors constitutes interaction of CBN with the endocannabinoid system (ECS). CBN ...
(CBN) was the first compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940, followed by some of the first preclinical research studies to determine the effects of individual cannabis-derived compounds in vivo. Globally, in 2013, 60,400 kilograms of cannabis were produced legally.


Recreational use

Cannabis is a popular recreational drug around the world, only behind alcohol,
caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is mainly used recreationally as a cognitive enhancer, increasing alertness and attentional performance. Caffeine acts by blocking binding of adenosine to ...
, and
tobacco Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ...
. In the U.S. alone, it is believed that over 100 million Americans have tried cannabis, with 25 million Americans having used it within the past year. As a drug it usually comes in the form of dried
infructescence Infructescence (fruiting head) is defined as the ensemble of fruits derived from the ovaries of an inflorescence. It usually retains the size and structure of the inflorescence. In some cases, infructescences are similar in appearance to simple fru ...
s ("buds" or "marijuana"),
resin In polymer chemistry and materials science, resin is a solid or highly viscous substance of plant or synthetic origin that is typically convertible into polymers. Resins are usually mixtures of organic compounds. This article focuses on natu ...
( hashish), or various extracts collectively known as
hash oil Hash oil or cannabis oil, is an oleoresin obtained by the extraction of cannabis or hashish. It is a cannabis concentrate containing many of its resins and terpenes – in particular, tetrahydrocannabinol (THC), cannabidiol (CBD), and other ...
. During the 20th century, it became illegal in most of the world to cultivate or possess ''Cannabis'' for sale, and even sometimes for personal use. The psychoactive effects of ''cannabis'' are known to have a triphasic nature. Primary psychoactive effects include a state of relaxation, and to a lesser degree, euphoria from its main psychoactive compound, THC. Secondary psychoactive effects, such as a facility for philosophical thinking,
introspection Introspection is the examination of one's own conscious thoughts and feelings. In psychology, the process of introspection relies on the observation of one's mental state, while in a spiritual context it may refer to the examination of one's s ...
and
metacognition Metacognition is an awareness of one's thought processes and an understanding of the patterns behind them. The term comes from the root word '' meta'', meaning "beyond", or "on top of".Metcalfe, J., & Shimamura, A. P. (1994). ''Metacognition: knowi ...
have been reported among cases of
anxiety Anxiety is an emotion which is characterized by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. Anxiety is different than fear in that the former is defined as the anticipation of a future threat wh ...
and
paranoia Paranoia is an instinct or thought process that is believed to be heavily influenced by anxiety or fear, often to the point of delusion and irrationality. Paranoid thinking typically includes persecutory beliefs, or beliefs of conspiracy co ...
. Finally, the tertiary psychoactive effects of the drug cannabis, can include an increase in heart rate and hunger, believed to be caused by
11-OH-THC 11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-Δ9-THC, alternatively numbered as 7-OH-Δ1-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after THC is consumed. A ...
, a psychoactive metabolite of THC produced in the
liver The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for ...
. Normal cognition is restored after approximately three hours for larger doses via a
smoking pipe A smoking pipe is used to inhale the smoke of a burning substance; most common is a tobacco pipe, which can also accommodate almost any other substance. Pipes are commonly made from briar, heather, corn, meerschaum, clay, cherry, glass, porcela ...
,
bong A bong (also known as a water pipe) is a filtration device generally used for smoking cannabis, tobacco, or other herbal substances. In the bong shown in the photo, the gas flows from the lower port on the left to the upper port on the right. ...
or
vaporizer Vaporizer or vaporiser may refer to: *Anesthetic vaporizer, a device used in the administration of anesthesia * Electronic cigarette, or a part of one (often called a "PV" or "personal vaporizer") *Humidifier, a household appliance that increases ...
. However, if a large amount is taken orally the effects may last much longer. After 24 hours to a few days, minuscule psychoactive effects may be felt, depending on dosage, frequency and tolerance to the drug. Various forms of the drug cannabis exist, including extracts such as hashish and hash oil which, because of appearance, are more susceptible to
adulterant An adulterant is caused by the act of adulteration, a practice of secretly mixing a substance with another. Typical substances that are adulterated include but are not limited to food, cosmetics, pharmaceuticals, fuel, or other chemicals, that ...
s when left unregulated. Cannabidiol (CBD), which has no intoxicating effects by itself (although sometimes showing a small stimulant effect, similar to
caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is mainly used recreationally as a cognitive enhancer, increasing alertness and attentional performance. Caffeine acts by blocking binding of adenosine to ...
), is thought to attenuate (i.e., reduce) the anxiety-inducing effects of high doses of THC, particularly if administered orally prior to THC exposure. According to Delphic analysis by British researchers in 2007, cannabis has a lower risk factor for dependence compared to both nicotine and alcohol. However, everyday use of cannabis may be correlated with psychological
withdrawal symptoms Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome, is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs. In order for the symptoms of wit ...
, such as irritability or insomnia, and susceptibility to a
panic attack Panic attacks are sudden periods of intense fear and discomfort that may include palpitations, sweating, chest pain or chest discomfort, shortness of breath, trembling, dizziness, numbness, confusion, or a feeling of impending doom or of losing ...
may increase as levels of THC metabolites rise. Cannabis withdrawal symptoms are typically mild and are not life-threatening. Risk of adverse outcomes from cannabis use may be reduced by implementation of evidence-based education and intervention tools communicated to the public with practical regulation measures. In 2014 there were an estimated 182.5 million cannabis users worldwide (3.8% of the global population aged 15–64). This percentage did not change significantly between 1998 and 2014.


Medical use

Medical cannabis (or medical marijuana) refers to the use of cannabis and its constituent cannabinoids, in an effort to treat disease or improve symptoms. Cannabis is used to reduce nausea and vomiting during
chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...
, to improve appetite in people with
HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...
, and to treat
chronic pain Chronic pain is classified as pain that lasts longer than three to six months. In medicine, the distinction between acute and chronic pain is sometimes determined by the amount of time since onset. Two commonly used markers are pain that continue ...
and
muscle spasms A spasm is a sudden involuntary contraction of a muscle, a group of muscles, or a hollow organ such as the bladder. A spasmodic muscle contraction may be caused by many medical conditions, including dystonia. Most commonly, it is a muscle c ...
. Cannabinoids are under preliminary research for their potential to affect stroke. Evidence is lacking for depression, anxiety,
attention deficit hyperactivity disorder Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by excessive amounts of inattention, hyperactivity, and impulsivity that are pervasive, impairing in multiple contexts, and otherwise age-inap ...
,
Tourette syndrome Tourette syndrome or Tourette's syndrome (abbreviated as TS or Tourette's) is a common neurodevelopmental disorder that begins in childhood or adolescence. It is characterized by multiple movement (motor) tics and at least one vocal (phonic) ...
,
post-traumatic stress disorder Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder that can develop because of exposure to a traumatic event, such as sexual assault, warfare, traffic collisions, child abuse, domestic violence, or other threats on ...
, and psychosis. Two extracts of cannabis –
dronabinol The International Nonproprietary Name Dronabinol, also known as delta-9-tetrahydrocannabinol, or under the trade names Marinol, Syndros, Reduvo and Adversa, is a generic name for the molecule of delta-9-tetrahydrocannabinol in the pharmaceutic ...
and
nabilone Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It mimics tetrahydrocannabinol (THC), the primary psychoactive compound ...
– are approved by the FDA as medications in pill form for treating the
side effect In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...
s of
chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...
and AIDS. Short-term use increases both minor and major adverse effects. Common side effects include dizziness, feeling tired, vomiting, and hallucinations.
Long-term effects of cannabis The long-term effects of cannabis have been the subject of ongoing debate. Because cannabis is illegal in most countries, clinical research presents a challenge and there is limited evidence from which to draw conclusions. In 2017, the U.S. Natio ...
are not clear. Concerns including memory and cognition problems, risk of addiction,
schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...
in young people, and the risk of children taking it by accident.


Industrial use (hemp)

The term ''hemp'' is used to name the durable soft fiber from the ''Cannabis''
plant stem A stem is one of two main structural axes of a vascular plant, the other being the root. It supports leaves, flowers and fruits, transports water and dissolved substances between the roots and the shoots in the xylem and phloem, stores nutrien ...
(stalk). ''Cannabis sativa'' cultivars are used for fibers due to their long stems; Sativa varieties may grow more than six metres tall. However, ''hemp'' can refer to any industrial or foodstuff product that is not intended for use as a drug. Many countries regulate limits for psychoactive compound (
THC Tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C21H30O2) describes multiple isomers, the term ''THC' ...
) concentrations in products labeled as hemp. Cannabis for industrial uses is valuable in tens of thousands of commercial products, especially as fibre ranging from
paper Paper is a thin sheet material produced by mechanically or chemically processing cellulose fibres derived from wood, rags, grasses or other vegetable sources in water, draining the water through fine mesh leaving the fibre evenly distributed ...
, cordage,
construction material This is a list of building materials. Many types of building materials are used in the construction industry to create buildings and structures. These categories of materials and products are used by architects and construction project managers ...
and textiles in general, to
clothing Clothing (also known as clothes, apparel, and attire) are items worn on the body. Typically, clothing is made of fabrics or textiles, but over time it has included garments made from animal skin and other thin sheets of materials and natural ...
. Hemp is stronger and longer-lasting than
cotton Cotton is a soft, fluffy staple fiber that grows in a boll, or protective case, around the seeds of the cotton plants of the genus ''Gossypium'' in the mallow family Malvaceae. The fiber is almost pure cellulose, and can contain minor perce ...
. It also is a useful source of foodstuffs (hemp milk, hemp seed, hemp oil) and biofuels. Hemp has been used by many civilizations, from
China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...
to
Europe Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...
(and later
North America North America is a continent in the Northern Hemisphere and almost entirely within the Western Hemisphere. It is bordered to the north by the Arctic Ocean, to the east by the Atlantic Ocean, to the southeast by South America and the Car ...
) during the last 12,000 years. In modern times novel applications and improvements have been explored with modest commercial success. In the US, "industrial hemp" is classified by the federal government as cannabis containing no more than 0.3% THC by dry weight. This classification was established in the 2018 Farm Bill and was refined to include hemp-sourced extracts, cannabinoids, and derivatives in the definition of hemp.


Ancient and religious uses

The Cannabis plant has a history of medicinal use dating back thousands of years across many cultures. The Yanghai Tombs, a vast ancient cemetery (54 000 m2) situated in the
Turfan Turpan (also known as Turfan or Tulufan, , ug, تۇرپان) is a prefecture-level city located in the east of the autonomous region of Xinjiang, China. It has an area of and a population of 632,000 (2015). Geonyms The original name of the cit ...
district of the
Xinjiang Uyghur Autonomous Region Xinjiang, SASM/GNC: ''Xinjang''; zh, c=, p=Xīnjiāng; formerly romanized as Sinkiang (, ), officially the Xinjiang Uygur Autonomous Region (XUAR), is an autonomous region of the People's Republic of China (PRC), located in the northwest ...
in northwest China, have revealed the 2700-year-old grave of a
shaman Shamanism is a religious practice that involves a practitioner (shaman) interacting with what they believe to be a spirit world through altered states of consciousness, such as trance. The goal of this is usually to direct spirits or spir ...
. He is thought to have belonged to the
Jushi culture The Jushi (), or Gushi (), were a people who established a kingdom during the 1st millennium BC in the Turpan basin (modern Xinjiang, China). The kingdom included the area of Ayding Lake, in the eastern Tian Shan range. During the late 2nd and ear ...
recorded in the area centuries later in the ''
Hanshu The ''Book of Han'' or ''History of the Former Han'' (Qián Hàn Shū,《前汉书》) is a history of China finished in 111AD, covering the Western, or Former Han dynasty from the first emperor in 206 BCE to the fall of Wang Mang in 23 CE. I ...
'', Chap 96B. Near the head and foot of the shaman was a large leather basket and wooden bowl filled with 789g of cannabis, superbly preserved by climatic and burial conditions. An international team demonstrated that this material contained THC. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. This is the oldest documentation of cannabis as a pharmacologically active agent. The earliest evidence of cannabis smoking has been found in the 2,500-year-old tombs of Jirzankal Cemetery in the Pamir Mountains in Western China, where cannabis residue were found in burners with charred pebbles possibly used during funeral rituals. Settlements which date from c. 2200–1700 BCE in the
Bactria Bactria (; Bactrian: , ), or Bactriana, was an ancient region in Central Asia in Amu Darya's middle stream, stretching north of the Hindu Kush, west of the Pamirs and south of the Gissar range, covering the northern part of Afghanistan, southwe ...
and
Margiana Margiana ( el, ''Margianḗ'', Old Persian: ''Marguš'', Middle Persian: ''Marv'') is a historical region centred on the oasis of Merv and was a minor satrapy within the Achaemenid satrapy of Bactria, and a province within its successors, the Se ...
contained elaborate ritual structures with rooms containing everything needed for making drinks containing extracts from poppy (opium), hemp (cannabis), and
ephedra Ephedra may refer to: * Ephedra (medicine), a medicinal preparation from the plant ''Ephedra sinica'' * ''Ephedra'' (plant), genus of gymnosperm shrubs See also * Ephedrine Ephedrine is a central nervous system (CNS) stimulant that is of ...
(which contains
ephedrine Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in ...
). Although there is no evidence of ephedra being used by steppe tribes, they engaged in cultic use of hemp. Cultic use ranged from
Romania Romania ( ; ro, România ) is a country located at the crossroads of Central Europe, Central, Eastern Europe, Eastern, and Southeast Europe, Southeastern Europe. It borders Bulgaria to the south, Ukraine to the north, Hungary to the west, S ...
to the
Yenisei River The Yenisey (russian: Енисе́й, ''Yeniséy''; mn, Горлог мөрөн, ''Gorlog mörön''; Buryat: Горлог мүрэн, ''Gorlog müren''; Tuvan: Улуг-Хем, ''Uluğ-Hem''; Khakas: Ким суғ, ''Kim suğ''; Ket: Ӄук, ...
and had begun by 3rd millennium BC Smoking hemp has been found at Pazyryk. ''Cannabis'' is first referred to in
Hindu Hindus (; ) are people who religiously adhere to Hinduism.Jeffery D. Long (2007), A Vision for Hinduism, IB Tauris, , pages 35–37 Historically, the term has also been used as a geographical, cultural, and later religious identifier for ...
Vedas upright=1.2, The Vedas are ancient Sanskrit texts of Hinduism. Above: A page from the '' Atharvaveda''. The Vedas (, , ) are a large body of religious texts originating in ancient India. Composed in Vedic Sanskrit, the texts constitute the ...
between 2000 and 1400 BCE, in the '' Atharvaveda''. By the 10th century CE, it has been suggested that it was referred to by some in India as "food of the gods". Cannabis use eventually became a ritual part of the Hindu festival of
Holi Holi (), also known as the Festival of Colours, the Festival of Spring, and the Festival of Love,The New Oxford Dictionary of English (1998) p. 874 "Holi /'həʊli:/ noun a Hindu spring festival ...". is an ancient Hindu religious festival ...
. One of the earliest to use this plant in medical purposes was
Korakkar Korakkar is originally a Tamil Siddhar, and one of the 18 celebrated siddhars of Tamilnadu. He is none other than Gorakhnath, the Siddha as he is venerated throughout India. He was a student of the Siddhars Agathiyar and Bogar, and is mentioned var ...
, one of the 18
Siddha ''Siddha'' (Sanskrit: '; "perfected one") is a term that is used widely in Indian religions and culture. It means "one who is accomplished." It refers to perfected masters who have achieved a high degree of physical as well as spiritual ...
s. The plant is called ''Korakkar Mooli'' in the
Tamil language Tamil (; ' , ) is a Dravidian language natively spoken by the Tamil people of South Asia. Tamil is an official language of the Indian state of Tamil Nadu, the sovereign nations of Sri Lanka and Singapore, and the Indian territory of Pudu ...
, meaning Korakkar's herb. In
Buddhism Buddhism ( , ), also known as Buddha Dharma and Dharmavinaya (), is an Indian religion or philosophical tradition based on teachings attributed to the Buddha. It originated in northern India as a -movement in the 5th century BCE, and gra ...
, cannabis is generally regarded as an intoxicant and may be a hindrance to development of
meditation Meditation is a practice in which an individual uses a technique – such as mindfulness, or focusing the mind on a particular object, thought, or activity – to train attention and awareness, and achieve a mentally clear and emotionally cal ...
and clear awareness. In ancient
Germanic culture Germanic culture is a term referring to the culture of Germanic peoples, and can be used to refer to a range of time periods and nationalities, but is most commonly used in either a historical or contemporary context to denote groups that derive fro ...
, ''Cannabis'' was associated with the Norse love goddess,
Freya In Norse paganism, Freyja (Old Norse "(the) Lady") is a goddess associated with love, beauty, fertility, sex, war, gold, and seiðr (magic for seeing and influencing the future). Freyja is the owner of the necklace Brísingamen, rides a chario ...
. An anointing oil mentioned in Exodus is, by some translators, said to contain ''Cannabis''.
Sufi Sufism ( ar, ''aṣ-ṣūfiyya''), also known as Tasawwuf ( ''at-taṣawwuf''), is a mystic body of religious practice, found mainly within Sunni Islam but also within Shia Islam, which is characterized by a focus on Islamic spirituality, ...
s have used ''Cannabis'' in a spiritual context since the 13th century CE. In modern times, the
Rastafari movement Rastafari, sometimes called Rastafarianism, is a religion that developed in Jamaica during the 1930s. It is classified as both a new religious movement and a social movement by scholars of religion. There is no central authority in control of ...
has embraced ''Cannabis'' as a sacrament. Elders of the Ethiopian Zion Coptic Church, a religious movement founded in the U.S. in 1975 with no ties to either
Ethiopia Ethiopia, , om, Itiyoophiyaa, so, Itoobiya, ti, ኢትዮጵያ, Ítiyop'iya, aa, Itiyoppiya officially the Federal Democratic Republic of Ethiopia, is a landlocked country in the Horn of Africa. It shares borders with Eritrea to the ...
or the
Coptic Church The Coptic Orthodox Church ( cop, Ϯⲉⲕ̀ⲕⲗⲏⲥⲓⲁ ⲛ̀ⲣⲉⲙⲛ̀ⲭⲏⲙⲓ ⲛ̀ⲟⲣⲑⲟⲇⲟⲝⲟⲥ, translit=Ti.eklyseya en.remenkimi en.orthodoxos, lit=the Egyptian Orthodox Church; ar, الكنيسة القبطي ...
, consider ''Cannabis'' to be the
Eucharist The Eucharist (; from Greek , , ), also known as Holy Communion and the Lord's Supper, is a Christian rite that is considered a sacrament in most churches, and as an ordinance in others. According to the New Testament, the rite was instit ...
, claiming it as an oral tradition from Ethiopia dating back to the time of
Christ Jesus, likely from he, יֵשׁוּעַ, translit=Yēšūaʿ, label=Hebrew/Aramaic ( AD 30 or 33), also referred to as Jesus Christ or Jesus of Nazareth (among other names and titles), was a first-century Jewish preacher and religious ...
. Like the Rastafari, some modern
Gnostic Gnosticism (from grc, γνωστικός, gnōstikós, , 'having knowledge') is a collection of religious ideas and systems which coalesced in the late 1st century AD among Jewish and early Christian sects. These various groups emphasized pe ...
Christian sects have asserted that ''Cannabis'' is the
Tree of Life The tree of life is a fundamental archetype in many of the world's mythological, religious, and philosophical traditions. It is closely related to the concept of the sacred tree.Giovino, Mariana (2007). ''The Assyrian Sacred Tree: A Hist ...
. Other organized religions founded in the 20th century that treat ''Cannabis'' as a
sacrament A sacrament is a Christianity, Christian Rite (Christianity), rite that is recognized as being particularly important and significant. There are various views on the existence and meaning of such rites. Many Christians consider the sacraments ...
are the
THC Ministry The THC Ministry, founded by Roger Christie from the Religion of Jesus Church, is a religion which considers cannabis to be a sacrament. Members base their practices on what they see as an eclectic mixture of ancient wisdom, modern science, and ...
, Cantheism, the Cannabis Assembly and the
Church of Cognizance The Church of Cognizance (COC) was founded in 1991 by Danuel & Mary Quaintance in Graham County (Pima) Arizona, United States. Beginnings In 1994, the Quaintances recorded a 16-page "Declaration of Religious Sentiment" concretizing the establishme ...
. Cannabis is frequently used among
Sufi Sufism ( ar, ''aṣ-ṣūfiyya''), also known as Tasawwuf ( ''at-taṣawwuf''), is a mystic body of religious practice, found mainly within Sunni Islam but also within Shia Islam, which is characterized by a focus on Islamic spirituality, ...
s – the mystical interpretation of
Islam Islam (; ar, ۘالِإسلَام, , ) is an Abrahamic religions, Abrahamic Monotheism#Islam, monotheistic religion centred primarily around the Quran, a religious text considered by Muslims to be the direct word of God in Islam, God (or ...
that exerts strong influence over local Muslim practices in
Bangladesh Bangladesh (}, ), officially the People's Republic of Bangladesh, is a country in South Asia. It is the eighth-most populous country in the world, with a population exceeding 165 million people in an area of . Bangladesh is among the mos ...
,
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
,
Indonesia Indonesia, officially the Republic of Indonesia, is a country in Southeast Asia and Oceania between the Indian and Pacific oceans. It consists of over 17,000 islands, including Sumatra, Java, Sulawesi, and parts of Borneo and New Guine ...
,
Turkey Turkey ( tr, Türkiye ), officially the Republic of Türkiye ( tr, Türkiye Cumhuriyeti, links=no ), is a list of transcontinental countries, transcontinental country located mainly on the Anatolia, Anatolian Peninsula in Western Asia, with ...
, and
Pakistan Pakistan ( ur, ), officially the Islamic Republic of Pakistan ( ur, , label=none), is a country in South Asia. It is the world's List of countries and dependencies by population, fifth-most populous country, with a population of almost 24 ...
. Cannabis preparations are frequently used at Sufi festivals in those countries. Pakistan's
Shrine of Lal Shahbaz Qalandar The Shrine of Lal Shabaz Qalandar ( ur, ; sd, لال شهباز قلندر جي مزار) is a shrine and mausoleum dedicated to the 13th century Muslim and Sufi saint, Lal Shahbaz Qalandar. The shrine is located in Sehwan Sharif, in the Pakist ...
in
Sindh Sindh (; ; ur, , ; historically romanized as Sind) is one of the four provinces of Pakistan. Located in the southeastern region of the country, Sindh is the third-largest province of Pakistan by land area and the second-largest province ...
province is particularly renowned for the widespread use of cannabis at the shrine's celebrations, especially its annual ''
Urs Urs (from ''‘Urs'') or ''Urus'' (literal meaning wedding), is the death anniversary of a Sufi saint, usually held at the saint's dargah (shrine or tomb). In most Sufi orders such as Naqshbandiyyah, Suhrawardiyya, Chishtiyya, Qadiriyya, etc ...
'' festival and Thursday evening ''dhamaal'' sessions – or meditative dancing sessions.


See also

*
Cannabis drug testing Cannabis drug testing describes various drug testing, drug test methodologies for the use of Cannabis (drug), cannabis in Medical cannabis, medicine, Cannabis and sports, sport, and Legality of cannabis, law. Cannabis use is highly detectable and ...
*
Cannabis edible A cannabis edible, also known as a cannabis-infused food or simply an edible, is a food product (either homemade or produced commercially) that contains decarboxylated cannabinoids (cannabinoid acids converted to their orally bioactive form) ...
* Cannabis flower essential oil *
Hash, Marihuana & Hemp Museum The Hash, Marihuana & Hemp Museum is a museum located in De Wallen, Amsterdam, Netherlands. According to the museum, more than two million visitors have visited the exhibition since it opened in 1985. Dedicated to cannabis and its many uses, the m ...
*
Indian Hemp Drugs Commission The Indian Hemp Drugs Commission Report, completed in 1894, was an Indo-British study of cannabis usage in British India. By 2 March 1893, the House of Commons of the United Kingdom was concerned with the effects of hemp drugs in the province o ...
*
Legal history of cannabis in the United States In the United States, increased restrictions and labeling of cannabis (legal term ''marijuana'' or ''marihuana'') as a poison began in many states from 1906 onward, and outright prohibitions began in the 1920s. By the mid-1930s cannabis was regu ...
* Occupational health concerns of cannabis use


References


Further reading

* * * * * * * * * * *


External links


International Plant Names Index (IPNI)
{{Authority control Rosales genera Dioecious plants Entheogens Euphoriants Herbs Medicinal plants Soma (drink) Taxa named by Carl Linnaeus Invasive plant species in Japan