Chloralose (also known as α-chloralose) is an

avicide An avicide is any substance (normally a chemical) used to kill birds. Commonly used avicides include strychnine (also used as rodenticide and predacide), DRC-1339 (3-chloro-4-methylaniline hydrochloride, Starlicide) and CPTH (3-chloro-p-toluidi ...

, and a

rodenticide Rodenticides are chemicals made and sold for the purpose of killing rodents. While commonly referred to as "rat poison", rodenticides are also used to kill mice, woodchucks, chipmunks, porcupines, nutria, beavers, and voles. Some rodenticides ...

used to kill mice in temperatures below 15 °C. It is also widely used in

neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...

and veterinary medicine as an

anesthetic An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness. They may be divided into t ...

and

sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its decelera ...

. Either alone or in combination, such as with urethane, it is used for long-lasting, but light anesthesia. It has been used with oral administration to sedate wild Canada geese for translocation in Nevada. Chemically, it is a

chlorinated In chemistry, halogenation is a chemical reaction which introduces one or more halogens into a chemical compound. Halide-containing compounds are pervasive, making this type of transformation important, e.g. in the production of polymers, drugs. ...

acetal In organic chemistry, an acetal is a functional group with the connectivity . Here, the R groups can be organic fragments (a carbon atom, with arbitrary other atoms attached to that) or hydrogen, while the R' groups must be organic fragments n ...

derivative of

glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...

. Chloralose exerts

barbiturate Barbiturates are a class of depressant, depressant drugs that are chemically derived from barbituric acid. They are effective when used medication, medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological a ...

-like actions on

synaptic transmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron) ...

in the brain, including potent effects at inhibitory γ-aminobutyric acid type A receptors (GABA_AR). A structural isomer of chloralose, β-chloralose (also called parachloralose in older literature), is inactive as a GABA_AR modulator and also as a general anesthetic. Chloralose is often abused for its avicide properties. In the

United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotlan ...

, protected birds of prey have been killed using the chemical. Legal use for bird control also often causes raptor mortalities from secondary poisoning, as well as primary poisoning of non-target species from eating bait, for example,

kererū The kererū (''Hemiphaga novaeseelandiae''), also known as kūkupa (Māori language#Northern dialects, northern Māori dialects), New Zealand pigeon or wood pigeon, is a species of pigeon native to New Zealand. Johann Friedrich Gmelin describ ...

pigeon in New Zealand.

References

Acetals Polyols Monosaccharide derivatives Rodenticides Avicides GABAA receptor positive allosteric modulators Sedatives General anesthetics Trichloromethyl compounds Heterocyclic compounds with 2 rings Oxygen heterocycles {{sedative-stub