Charles Walter Suckling (24 July 1920 – 31 October 2013) was a British

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...

who first synthesised

halothane Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. It can be used to induce or maintain anaesthesia. One of its benefits is that it does not increase the production of saliva, which can be particularly useful ...

, a volatile inhalational anaesthetic in 1951, while working at the

Imperial Chemical Industries Imperial Chemical Industries (ICI) was a British Chemical industry, chemical company. It was, for much of its history, the largest manufacturer in Britain. Its headquarters were at Millbank in London. ICI was listed on the London Stock Exchange ...

(ICI) Central Laboratory in

Widnes Widnes ( ) is an Industrial city, industrial town in the Borough of Halton, Cheshire, England, which at the 2021–2022 United Kingdom censuses, 2021 census had a population of 62,400. Historic counties of England, Historically in Lancashire, ...

Biography

He was born in Teddington, London in 1920, the son of Edward Ernest and Barbara (née Thomson) Suckling, and educated at Oldershaw Grammar School, Wallasey and Liverpool University.McCann, Michael J.; Suckling, Colin J. (2019). "Charles Walter Suckling. 24 July 1920—30 October 2013". ''Biographical Memoirs of Fellows of the Royal Society''
doi.org/10.1098/rsbm.2018.0025
/ref> He worked, initially as a research chemist, for ICI from 1942 to 1982, becoming Deputy Chairman of Mond Division in 1969 and Chairman of Paints Division in 1972, finally being appointed General Manager of Research in 1977 (until retirement in 1982). He was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

in 1978. He married Eleanor Margaret Watterson in 1946; they had two sons and a daughter. He died on 31 October 2013.Dr Charles Walter Suckling CBE FRS
/ref>

Halothane research

At the time of Suckling's original research, the main anaesthetic gases in use were

chloroform Chloroform, or trichloromethane (often abbreviated as TCM), is an organochloride with the formula and a common solvent. It is a volatile, colorless, sweet-smelling, dense liquid produced on a large scale as a precursor to refrigerants and po ...

and

diethyl ether Diethyl ether, or simply ether, is an organic compound with the chemical formula , sometimes abbreviated as . It is a colourless, highly Volatility (chemistry), volatile, sweet-smelling ("ethereal odour"), extremely flammable liquid. It belongs ...

, both of which had several serious drawbacks. Ether was highly flammable, which was particularly dangerous in operating theatres as electrical equipment such as

diathermy Diathermy is electrically induced heat or the use of high-frequency electromagnetic currents as a form of physical therapy and in surgical procedures. The earliest observations on the reactions of the human organism to high-frequency electromagn ...

became more common. Chloroform was toxic to the liver. The

halogenated In chemistry, halogenation is a chemical reaction which introduces one or more halogens into a chemical compound. Halide-containing compounds are pervasive, making this type of transformation important, e.g. in the production of polymers, drugs ...

alkane In organic chemistry, an alkane, or paraffin (a historical trivial name that also has other meanings), is an acyclic saturated hydrocarbon. In other words, an alkane consists of hydrogen and carbon atoms arranged in a tree structure in whi ...

s (alkyl halides, also known as

haloalkane The haloalkanes (also known as halogenoalkanes or alkyl halides) are alkanes containing one or more halogen substituents of hydrogen atom. They are a subset of the general class of halocarbons, although the distinction is not often made. Haloalka ...

s) in general, and in particular the

fluorinated In chemistry, halogenation is a chemical reaction which introduces one or more halogens into a chemical compound. Halide-containing compounds are pervasive, making this type of transformation important, e.g. in the production of polymers, drugs. ...

compounds were promising because they were volatile but not

flammable A combustible material is a material that can burn (i.e., sustain a flame) in air under certain conditions. A material is flammable if it ignites easily at ambient temperatures. In other words, a combustible material ignites with some effort ...

. Suckling had worked on such compounds extensively during

World War II World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...

, when they were used in the production of high-octane aviation fuel, and in the purification of uranium-235. He proceeded to synthesise a variety of fluorinated hydrocarbons before evaluating them for anaesthetic properties. He liaised closely with clinicians, initially in setting target physicochemical properties for ideal agents and then later in evaluating the developed compounds. Suckling first investigated halothane's anaesthetic action by experimenting on

mealworm Mealworms are the larval form of the yellow mealworm beetle, ''Tenebrio molitor'', a species of darkling beetle. The yellow mealworm beetle prefers a warmer climate and higher humidity. Male mealworm beetles release a sex pheromone to attract ...

s and houseflies, and then forwarded it to Jaume Raventos, a pharmacologist, for evaluation of anaesthesia in other animals. After Raventos established its pharmacological properties, it was given to Michael Johnstone, an anaesthetist in

Manchester Manchester () is a city and the metropolitan borough of Greater Manchester, England. It had an estimated population of in . Greater Manchester is the third-most populous metropolitan area in the United Kingdom, with a population of 2.92&nbs ...

, England, who recognised its great advantages over the other anaesthetics available and established its first clinical trial in 1956. This process of systematic study of chemical compounds with a set of pre-defined characteristics has been identified as one of the first examples of modern

drug design Drug design, often referred to as rational drug design or simply rational design, is the invention, inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic compound, organi ...

Biography

Halothane research

References

Further reading