CanSino Biologics ( zh, s=康希诺生物 , t=康希諾生物 , hp=Kāngxīnuò Shēngwù), often abbreviated as CanSinoBIO, is a Chinese

vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifi ...

company.

History

CanSino Biologics was founded in 2009 in

Tianjin Tianjin is a direct-administered municipality in North China, northern China on the shore of the Bohai Sea. It is one of the National Central City, nine national central cities, with a total population of 13,866,009 inhabitants at the time of the ...

by Yu Xuefeng, Zhu Tao, Qiu Dongxu and Helen Mao Huihua. In July 2018, it filed an application to list on the

Hong Kong Stock Exchange The Stock Exchange of Hong Kong (, SEHK, also known as Hong Kong Stock Exchange) is a stock exchange based in Hong Kong. It is one of the largest stock exchanges in Asia and the List of major stock exchanges, 9th largest globally by market ...

. It debuted on 28 March 2019 with an increase of 59%, the highest first day trading gain in Hong Kong since 2017. In August 2020, it completed a secondary offering on

Shanghai Stock Exchange The Shanghai Stock Exchange (, SSE) is a stock exchange based in the city of Shanghai, China. It is one of the three stock exchanges operating independently in mainland China, the others being the Beijing Stock Exchange and the Shenzhen Stock ...

's STAR market where it raised 5.2 billion yuan (US$750 million).

Vaccines

The company has a portfolio of vaccines under research including Ad5-EBOV to prevent

Ebola Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after in ...

and Ad5-nCoV for

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever ...

. The company has previously collaborated with the

National Research Council of Canada The National Research Council Canada (NRC; ) is the primary national agency of the Government of Canada dedicated to science and technology research and development. It is the largest federal research and development organization in Canada. Th ...

(NRC) on vaccine development. The two organizations began collaborating in 2013, and they later worked together to develop an Ebola vaccine.

COVID-19 vaccine development

AD5-nCOV, trade-named Convidecia, is a single-dose

viral vector A viral vector is a modified virus designed to gene delivery, deliver genetic material into cell (biology), cells. This process can be performed inside an organism or in cell culture. Viral vectors have widespread applications in basic research, ...

COVID-19 vaccine A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 ( COVID19). Knowledge about the structure and fun ...

developed by CanSino. Since late 2020, it has been in

Phase III trials The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phase ...

Chile Chile, officially the Republic of Chile, is a country in western South America. It is the southernmost country in the world and the closest to Antarctica, stretching along a narrow strip of land between the Andes, Andes Mountains and the Paci ...

Mexico Mexico, officially the United Mexican States, is a country in North America. It is the northernmost country in Latin America, and borders the United States to the north, and Guatemala and Belize to the southeast; while having maritime boundar ...

Pakistan Pakistan, officially the Islamic Republic of Pakistan, is a country in South Asia. It is the List of countries and dependencies by population, fifth-most populous country, with a population of over 241.5 million, having the Islam by country# ...

Russia Russia, or the Russian Federation, is a country spanning Eastern Europe and North Asia. It is the list of countries and dependencies by area, largest country in the world, and extends across Time in Russia, eleven time zones, sharing Borders ...

, and

Saudi Arabia Saudi Arabia, officially the Kingdom of Saudi Arabia (KSA), is a country in West Asia. Located in the centre of the Middle East, it covers the bulk of the Arabian Peninsula and has a land area of about , making it the List of Asian countries ...

with 40,000 participants. In February 2021, global data from Phase III trials and 101 COVID cases showed that the vaccine had a 65.7% efficacy in preventing moderate symptoms of

, and 91% efficacy in preventing severe disease. It has similar efficacy to the Janssen vaccine, another one-shot adenovirus vector vaccine with 66% efficacy in a global trial. Its single-dose regimen and normal refrigerator storage requirement make it a favorable vaccine option for many countries. The vaccine is approved for emergency use listing by the

WHO The World Health Organization (WHO) is a specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Geneva, Switzerland, and has 6 regional offices and 15 ...

. In April 2021, CanSino Biologics began clinical trials for a version of its COVID-19 vaccine administered by inhalation rather than injection. Rollout of inhaled boosters began in China in October 2022. Convidecia is approved for use by some countries in Asia, Latin America, and by Hungary. Production capacity for Ad5-NCov should reach 500 million doses in 2021. Manufacturing will take place in China, Malaysia, Mexico, and

Investors

CanSino Biologics investors included

Lilly Asia Ventures Eli Lilly and Company, doing business as Lilly, is an American multinational pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was fo ...

Qiming Venture Partners Qiming Venture Partners (Qiming; ) is a China-based venture capital firm. It primarily invests in technology, Internet and healthcare-related companies across China. It is an early investor in ByteDance, Xiaomi, Meituan, and Bilibili. According ...

and

SDIC Fund Management State Development and Investment Corporation (SDIC) (国家开发投资公司) is the largest state-owned investment holding company in China. It was established on 5 May 1995. SDIC's industrial investment mainly goes to power generation, coal ...

References

{{coord, 39.0739, 117.5430, display=title Chinese brands Chinese companies established in 2009 Companies based in Tianjin Pharmaceutical companies of China Vaccine producers COVID-19 vaccine producers 2009 in Tianjin

History

Vaccines

COVID-19 vaccine development

Investors

See also

References