Cullin-7 is a RING-E3 ligase
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CUL7''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Clinical significance
It is associated with
3-M syndrome.
Interactions
CUL7 has been shown to
interact
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with
RBX1
RING-box protein 1 is a protein that in humans is encoded by the ''RBX1'' gene.
Function
This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by hete ...
.
References
Further reading
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External links
GeneReviews/NIH/NCBI/UW entry on 3-M syndrome OMIM entries entry on 3-M syndrome*
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