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p120 catenin, or simply p120, also called catenin delta-1, is a
Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CTNND1'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.Clinical significance
Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.
Interactions
CTNND1 has been shown to interact with: * β-Catenin, * CDH1, * CDH2, * Collagen, type XVII, alpha 1, * Cortactin, * FYN, * MUC1, * Nephrin, * PSEN1, * PTPN6, * PTPRJ, * PTPRM, * VE-cadherin, * YES1, and * ZBTB33See also
* δ-Catenin * Catenin * CTNND2References
Further reading
* * * * * * * * * * * * * * * * * * *External links
* {{UCSC gene info, CTNND1 Catenins Armadillo-repeat-containing proteins