Protein Complex Enrichment Analysis Tool is an online
bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...
tool used to analyze high-throughput datasets (or small-scale datasets) using protein complex enrichment analysis.
The tool uses a protein complex resource as the back end annotation data instead of conventional
gene ontology
The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and g ...
- or pathway-based annotations. The tool incorporates several useful features in order to provide a comprehensive data-mining environment, including network-based visualization and interactive querying options.
COMPLEAT may be used to analyze
RNAi screens,
proteomic datasets,
gene expression data and any other
high-throughput datasets where protein complex information is relevant.
Applications
COMPLEAT has been successfully applied to identify:
*Dynamic protein complexes regulated by insulin and epidermal growth factors signaling, including a role of Brahma complex in the cellular response to insulin.
*Evolutionarily conserved molecular complexes that regulate nucleolar size when the complex constituents were targeted by RNA interference.
*Novel role of endocytosis and vesicle trafficking complexes in Hippo Signaling Pathway.
References
{{Reflist
External links
COMPLEAT
Data analysis software
Systems biology
Bioinformatics software