Chloride channel Kb, also known as CLCNKB, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
which in humans is encoded by the ''CLCNKB''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Chloride channel Kb (CLCNKB) is a member of the CLC family of
voltage-gated chloride channel
Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration ''in vivo'' is much higher than other anions. Several ...
s, which comprises at least 9 mammalian chloride channels.
Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III
Bartter syndrome.
and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in
mammalian kidney
The mammalian kidneys are a pair of excretory organs of the urinary system of mammals, being functioning Kidney (vertebrates), kidneys in postnatal-to-adult individuals (i. e. Kidney (vertebrates)#Metanephros, metanephric kidneys). The kidneys in ...
.
See also
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Chloride channel
Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration ''in vivo'' is much higher than other anions. Several ...
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BSND, barttin, accessory subunit beta for this channel
References
Further reading
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External links
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Ion channels
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