CKLF like MARVEL transmembrane domain-containing 8 (i.e. CMTM8), previously termed chemokine-like factor superfamily 8 (i.e. CKLFSF8) has at least two

isoforms A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some iso ...

, the CMTM8 and CMTM8-v2 proteins. Protein isoforms are variant products that are made by the alternative splicing of a single gene. The gene for these isoforms, ''CMTM8'' (formerly termed ''CKLFSF8''), is located in

band Band or BAND may refer to: Places *Bánd, a village in Hungary * Band, Iran, a village in Urmia County, West Azerbaijan Province, Iran * Band, Mureș, a commune in Romania * Band-e Majid Khan, a village in Bukan County, West Azerbaijan Province, ...

22 on the short (i.e. "p") arm of

chromosome 3 Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans almost 200 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA i ...

. The ''CMTM8'' gene and its CMTM8 and CMTM8-v2 proteins belong to the

CKLF-like MARVEL transmembrane domain-containing family The CKLF-like MARVEL transmembrane domain-containing family (CMTM), previously termed the chemokine-like factor superfamily (CKLFSF), consists of 9 proteins, some of which have various isoforms due to alternative splicing of their respective genes. ...

of structurally and functionally related genes and proteins. The CMTM8 protein is the full-length and predominant product of the ''CMTM8'' gene. This protein is expressed in a wide range of normal adult and fetal tissues while relatively little is known about the CMTM8-v2 protein. Studies suggest that the CMTM8 protein may be involved in the development of various cancers. The levels of CMTM8 protein are lower in the tissues of

non-small-cell lung carcinoma Non-small-cell lung cancer (NSCLC) is any type of epithelial lung cancer other than small-cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to sm ...

, colon cancer, rectal cancer, esophageal cancer, bladder cancer, stomach cancer, and

glioblastoma Glioblastoma, previously known as glioblastoma multiforme (GBM), is one of the most aggressive types of cancer that begin within the brain. Initially, signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality cha ...

brain tumors than in their respective adjacent normal organ tissues. The low levels of CMTM8 protein in bladder and stomach cancer tissues were associated with more aggressive diseases (e.g. presence of

metastases Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, the ...

) and poorer prognoses. These findings suggest that CMTM8 protein may inhibit the development and/or progression of the cited malignancies and therefore the ''CMTM8'' gene functions as a

tumor suppressor gene A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or re ...

. However, further studies are required to support these conclusions and to determine if the levels of CMTM8 protein can be used as prognostic markers for these malignancies and/or as a

targets ''Targets'' is a 1968 American crime thriller film directed by Peter Bogdanovich, produced by Roger Corman, and written by Polly Platt and Bogdanovich, with cinematography by László Kovács.Stephen Jacobs, ''Boris Karloff: More Than a Monste ...

for treating them.

References

{{reflist Human proteins DNA replication Gene expression Transcription coregulators