In
cell biology
Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living a ...
, CD11 is the α (alpha) component of various
integrin
Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, ...
s, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte adhesion. For example,
*
LFA1 (
CD11a/
CD18) short representation of ''Lymphocyte Function-associated Antigen'' 1, also called α
Lβ
2 integrin
*Mac1 (
CD11b/
CD18) present on
macrophages that is also called
Macrophage-1 antigen Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2).
The integrin α chain is noncovalently bound to the integrin β chain. It binds t ...
(CR3) and α
Mβ
2 integrin.
*
CD11c/
CD18 also called
complement
A complement is something that completes something else.
Complement may refer specifically to:
The arts
* Complement (music), an interval that, when added to another, spans an octave
** Aggregate complementation, the separation of pitch-clas ...
receptor 4 (CR4) and α
Xβ
2 integrin.
Clusters of differentiation
{{Protein-stub
wow