Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CBFA2T3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The t(16;21)(q24;q22) translocation is a rare but recurrent
chromosomal abnormality associated with therapy-related myeloid
malignancies. The translocation produces a chimeric gene made up of the 5'-region of the
AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast
tumor suppressor
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell (biology), cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results ...
. Two transcript variants encoding different isoforms have been found for this gene, and a
brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the
Golgi apparatus
The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic Cell (biology), cells. Part of the endomembrane system in the cytoplasm, it protein targeting, packages proteins ...
.
Interactions
CBFA2T3 has been shown to
interact with:
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HDAC1,
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HDAC3
Histone deacetylase 3 is an enzyme encoded by the ''HDAC3'' gene in both humans and mice.
Function
Histones are highly alkaline proteins that package and order DNA into structural units called nucleosomes, which comprise the major protein comp ...
,
[
* ]LDB1
LIM domain-binding protein 1 is a protein that in humans is encoded by the ''LDB1'' gene.
Interactions
LDB1 has been shown to interact with other proteins such as LMO4, TCF3
Transcription factor 3 (E2A immunoglobulin enhancer-binding factor ...
,[
* PRKAR2A,][ and
* ]TCF3
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the ''TCF3'' gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) e ...
.
References
Further reading
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External links
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Transcription factors
Oncogenes
{{gene-16-stub