CB-13 (CRA13, SAB-378) is a

cannabinoid Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoact ...

drug, which acts as a potent

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

at both the CB₁ and CB₂ receptors, but has poor

blood–brain barrier The blood–brain barrier (BBB) is a highly selective semipermeable membrane, semipermeable border of endothelium, endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system ...

penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as

catalepsy Catalepsy (from Ancient Greek , , "seizing, grasping") is a neurological condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain. Signs and symptoms Sympt ...

only appearing at much higher dose ranges. It has antihyperalgesic properties in animal studies, and has progressed to preliminary human trials.

Legal Status

As of October 2015 CB-13 is a controlled substance in China. CB-13 is a Schedule I controlled substance in North Dakota.

References

Cannabinoids Designer drugs Naphthalenes Aromatic ketones Naphthol ethers Peripherally selective drugs Ethers {{cannabinoid-stub

Legal Status

See also

References