C-type Natriuretic Peptide on:
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Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the ''NPPC'' gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (''CNP'').
Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (
Function
Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP ANP may refer to:
In politics and government
*Afghan National Police
*''Agência Nacional do Petróleo, Gás Natural e Biocombustíveis'' or National Agency of Petroleum, Natural Gas and Biofuels (Brazil), a regulatory agency in Brazil
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), brain natriuretic peptide ( BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized ''NPPC''. These peptides possess potent natriuretic Natriuresis is the process of sodium excretion in the urine through the action of the kidneys. It is promoted by ventricular and atrial natriuretic peptides as well as calcitonin, and inhibited by chemicals such as aldosterone. Natriuresis low ...
, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
for the B-type natriuretic receptor ( NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA). It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like ) and certain proinflammatory cytokines.
References
Further reading
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* {{gene-2-stub