Bryan Barnet Molloy (30 March 1939 – 20 May 2004) was a Scottish chemist, known notably for helping to invent the

antidepressant Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, akathi ...

''Prozac'', a name for

fluoxetine Fluoxetine, sold under the brand name Prozac, among others, is an Antidepressant, antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used for the treatment of major depressive disorder, Anxiety disorder, anx ...

. ''Prozac'' was introduced in 1988, and has been the world's leading antidepressant.

Early life

He was born in

Broughty Ferry Broughty Ferry (; ; ) is a suburb of Dundee, in Scotland. It is situated four miles east of the City Centre, Dundee, city centre on the north bank of the Firth of Tay. The area was a separate burgh from 1864 until 1913, when it was incorporated ...

, in the east of

Dundee Dundee (; ; or , ) is the List of towns and cities in Scotland by population, fourth-largest city in Scotland. The mid-year population estimate for the locality was . It lies within the eastern central Lowlands on the north bank of the Firt ...

. He received a BSc degree in Chemistry in 1960 from the

University of St Andrews The University of St Andrews (, ; abbreviated as St And in post-nominals) is a public university in St Andrews, Scotland. It is the List of oldest universities in continuous operation, oldest of the four ancient universities of Scotland and, f ...

, gaining a PhD in 1963.

Career

He moved to the US in 1963, working on research at three universities for three years, including

Imperial College London Imperial College London, also known as Imperial, is a Public university, public research university in London, England. Its history began with Prince Albert of Saxe-Coburg and Gotha, Prince Albert, husband of Queen Victoria, who envisioned a Al ...

. He researched the

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a Chemical synapse, synapse. The cell receiving the signal, or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotra ...

acetylcholine Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Par ...

, and its effect on the heart. Mechanism of Prozac

Prozac

He worked with David T. Wong and Klaus Schmiegel.

Tricyclic antidepressant Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. They are named after their chemical structure, which contains ...

s had been introduced in the 1950s, and further antidepressants included

monoamine oxidase inhibitor Monoamine oxidase inhibitors (MAOIs) are a drug class, class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressa ...

s (MAOIs); these had side-effects. In 1971, Wong and Molloy went to a lecture in

Indianapolis Indianapolis ( ), colloquially known as Indy, is the List of capitals in the United States, capital and List of municipalities in Indiana, most populous city of the U.S. state of Indiana and the county seat of Marion County, Indiana, Marion ...

given by Solomon H. Snyder, a neuroscientist at

Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, J ...

. This gave them a method to test new compounds similar to

antihistamine Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides ...

s found by Molloy, one being fluoxetine. Fluoxetine hydrochloride (3-aryloxy-3-phenylpropylamine, an aryloxyphenylpropylamine), the first of the

selective serotonin reuptake inhibitor Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs primarily work by blo ...

s (SSRIs), was inventor in 1972, and made public in 1974; work had begun with Robert Rathbun in 1970. Other well-known SSRIs would be

sertraline Sertraline, sold under the brand name Zoloft among others, is an Antidepressant, antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used to treat major depressive disorder, generalized anxiety disorder, socia ...

(''Zoloft'') from

Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...

, and

paroxetine Paroxetine ( ), sold under the brand name Paxil among others, is an Antidepressant, antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used to treat major depressive disorder, obsessive-compulsive disorder, o ...

(''Paxil'' or ''Seroxat'') from GSK. Fluoxetine is on the

WHO Model List of Essential Medicines The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...

. He later worked on

cardiovascular disease Cardiovascular disease (CVD) is any disease involving the heart or blood vessels. CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina, heart attack), heart failure, hypertensive heart disease, rheumati ...

and

cardiac arrhythmia Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. Essentially, this is anything but normal sinus rhythm. A resting heart rate that is too fast – above 100 beat ...

, and

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace ami ...

s as antidepressants. He retired in 2001.

Personal life

He married Kay Koch in 1971. They lived on a farm in

Indiana Indiana ( ) is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. It borders Lake Michigan to the northwest, Michigan to the north and northeast, Ohio to the east, the Ohio River and Kentucky to the s ...

. He had a pilot's licence. He became a US citizen in 1990. He died in 2004, aged 65, in

Marion County, Indiana Marion County is located in the U.S. state of Indiana. The 2020 United States census reported a population of 977,203, making it the 54th-most populous county in the U.S., the most populous county in the state, and the main population center ...

.Obituary
''lifestorynet.com''. He was listed in the

National Inventors Hall of Fame The National Inventors Hall of Fame (NIHF) is an American not-for-profit organization, founded in 1973, which recognizes individual engineers and inventors who hold a US patent of significant technology. Besides the Hall of Fame, it also operate ...

on 18 September 1999 at

Akron, Ohio Akron () is a city in Summit County, Ohio, United States, and its county seat. It is the List of municipalities in Ohio, fifth-most populous city in Ohio, with a population of 190,469 at the 2020 United States census, 2020 census. The Akron metr ...

References

External links

Google Patents

Breakthroughs in Bioscience
{{DEFAULTSORT:Molloy, Bryan 1939 births 2004 deaths Academics of Imperial College London Alumni of the University of St Andrews Eli Lilly and Company people People from Broughty Ferry 20th-century Scottish chemists Scottish emigrants to the United States 20th-century Scottish inventors Scottish neuroscientists