Cerebral circulation is the movement of

blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood is com ...

through a network of

cerebral arteries The cerebral arteries describe three main pairs of artery, arteries and their branches, which perfusion, perfuse the cerebrum of the brain. The three main arteries are the: * ''Anterior cerebral artery'' (ACA), which supplies blood to the medial ...

and

veins Veins () are blood vessels in the circulatory system of humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are those of the pulmonary and fetal c ...

supplying the

brain The brain is an organ (biology), organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head (cephalization), usually near organs for ...

. The rate of cerebral

blood flow Hemodynamics American and British English spelling differences#ae and oe, or haemodynamics are the Fluid dynamics, dynamics of blood flow. The circulatory system is controlled by homeostasis, homeostatic mechanisms of autoregulation, just as hydrau ...

in an adult

human Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing ...

is typically 750

milliliter The litre (Commonwealth English, Commonwealth spelling) or liter (American English, American spelling) (SI symbols L and l, other symbol used: ℓ) is a metric units, metric unit of volume. It is equal to 1 cubic decimetre (dm3), 1000 cubic c ...

s per

minute A minute is a unit of time defined as equal to 60 seconds. It is not a unit in the International System of Units (SI), but is accepted for use with SI. The SI symbol for minutes is min (without a dot). The prime symbol is also sometimes used i ...

, or about 15% of

cardiac output In cardiac physiology, cardiac output (CO), also known as heart output and often denoted by the symbols Q, \dot Q, or \dot Q_ , edited by Catherine E. Williamson, Phillip Bennett is the volumetric flow rate of the heart's pumping output: tha ...

Arteries An artery () is a blood vessel in humans and most other animals that takes oxygenated blood away from the heart in the systemic circulation to one or more parts of the body. Exceptions that carry deoxygenated blood are the pulmonary arteries in ...

deliver oxygenated blood,

glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...

and other nutrients to the brain.

Vein Veins () are blood vessels in the circulatory system of humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are those of the pulmonary and feta ...

s carry "used or spent" blood back to the

heart The heart is a muscular Organ (biology), organ found in humans and other animals. This organ pumps blood through the blood vessels. The heart and blood vessels together make the circulatory system. The pumped blood carries oxygen and nutrie ...

, to remove

carbon dioxide Carbon dioxide is a chemical compound with the chemical formula . It is made up of molecules that each have one carbon atom covalent bond, covalently double bonded to two oxygen atoms. It is found in a gas state at room temperature and at norma ...

lactic acid Lactic acid is an organic acid. It has the molecular formula C3H6O3. It is white in the solid state and it is miscible with water. When in the dissolved state, it forms a colorless solution. Production includes both artificial synthesis as wel ...

, and other

metabolic Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the ...

products. The

neurovascular unit The neurovascular unit (NVU) comprises the components of the brain that collectively regulate cerebral blood flow in order to deliver the requisite nutrients to activated neurons. The NVU addresses the brain's unique dilemma of having high energy ...

regulates cerebral blood flow so that activated neurons can be supplied with energy in the right amount and at the right time. Because the

would quickly suffer damage from any stoppage in blood supply, the cerebral circulatory system has safeguards including

autoregulation Autoregulation is a process within many biological systems, resulting from an internal adaptive mechanism that works to adjust (or mitigate) that system's response to stimuli. While most systems of the body show some degree of autoregulation, i ...

of the

blood vessel Blood vessels are the tubular structures of a circulatory system that transport blood throughout many Animal, animals’ bodies. Blood vessels transport blood cells, nutrients, and oxygen to most of the Tissue (biology), tissues of a Body (bi ...

s. The failure of these safeguards may result in a

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

. The

volume Volume is a measure of regions in three-dimensional space. It is often quantified numerically using SI derived units (such as the cubic metre and litre) or by various imperial or US customary units (such as the gallon, quart, cubic inch) ...

of blood in circulation is called the

cerebral blood flow Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain. The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output. ...

. Sudden intense accelerations change the gravitational forces perceived by bodies and can severely impair cerebral circulation and normal functions to the point of becoming serious life-threatening conditions. The following description is based on idealized human cerebral circulation. The pattern of circulation and its

nomenclature Nomenclature (, ) is a system of names or terms, or the rules for forming these terms in a particular field of arts or sciences. (The theoretical field studying nomenclature is sometimes referred to as ''onymology'' or ''taxonymy'' ). The principl ...

vary between organisms.

Anatomy

Blood supply

Blood supply to the brain is normally divided into anterior and posterior segments, relating to the different arteries that supply the brain. The two main pairs of arteries are the

internal carotid arteries The internal carotid artery is an artery in the neck which supplies the anterior and middle cerebral circulation. In human anatomy, the internal and external carotid arise from the common carotid artery, where it bifurcates at cervical verteb ...

(supply the anterior brain) and

vertebral arteries The vertebral arteries are major arteries of the neck. Typically, the vertebral arteries originate from the subclavian arteries. Each vessel courses superiorly along each side of the neck, merging within the skull to form the single, midline ...

(supplying the

brainstem The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. The midbrain is conti ...

and posterior brain). The anterior and posterior cerebral circulations are interconnected via bilateral posterior communicating arteries. They are part of the

circle of Willis The circle of Willis (also called Willis' circle, loop of Willis, cerebral arterial circle, and Willis polygon) is a circulatory anastomosis that supplies blood to the brain and surrounding structures in reptiles, birds and mammals, including huma ...

, which provides backup circulation to the brain. In case one of the supply arteries is occluded, the circle of Willis provides interconnections between the anterior and the posterior cerebral circulation along the floor of the cerebral vault, providing blood to tissues that would otherwise become

ischemic Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems ...

Anterior cerebral circulation

The anterior cerebral circulation is the blood supply to the anterior portion of the brain including

eye An eye is a sensory organ that allows an organism to perceive visual information. It detects light and converts it into electro-chemical impulses in neurons (neurones). It is part of an organism's visual system. In higher organisms, the ey ...

s. It is supplied by the following arteries: *

Internal carotid arteries The internal carotid artery is an artery in the neck which supplies the anterior and middle cerebral circulation. In human anatomy, the internal and external carotid arise from the common carotid artery, where it bifurcates at cervical verteb ...

: These large arteries are the medial branches of the common carotid arteries which enter the skull, as opposed to the

external carotid The external carotid artery is the major artery of the head and upper neck. It arises from the common carotid artery. It terminates by splitting into the superficial temporal and maxillary artery within the parotid gland. Structure Origin Th ...

branches which supply the facial tissues; the internal carotid artery branches into the

anterior cerebral artery The anterior cerebral artery (ACA) is one of a pair of cerebral arteries that supplies oxygenated blood to most midline portions of the frontal lobes and superior medial parietal lobes of the brain. The two anterior cerebral arteries arise from th ...

and continues to form the

middle cerebral artery The middle cerebral artery (MCA) is one of the three major paired cerebral artery, cerebral arteries that supply blood to the cerebrum. The MCA arises from the internal carotid artery and continues into the lateral sulcus where it then branches an ...

. *

Anterior cerebral artery The anterior cerebral artery (ACA) is one of a pair of cerebral arteries that supplies oxygenated blood to most midline portions of the frontal lobes and superior medial parietal lobes of the brain. The two anterior cerebral arteries arise from th ...

(ACA) **

Anterior communicating artery In human anatomy, the anterior communicating artery is a blood vessel of the brain that connects the left and right anterior cerebral arteries. Anatomy The anterior communicating artery connects the two anterior cerebral arteries across the com ...

: Connects both anterior cerebral arteries, within and along the floor of the cerebral vault. *

Middle cerebral artery The middle cerebral artery (MCA) is one of the three major paired cerebral artery, cerebral arteries that supply blood to the cerebrum. The MCA arises from the internal carotid artery and continues into the lateral sulcus where it then branches an ...

(MCA)

Posterior cerebral circulation

The posterior cerebral circulation is the blood supply to the posterior portion of the brain, including the

occipital lobe The occipital lobe is one of the four Lobes of the brain, major lobes of the cerebral cortex in the brain of mammals. The name derives from its position at the back of the head, from the Latin , 'behind', and , 'head'. The occipital lobe is the ...

cerebellum The cerebellum (: cerebella or cerebellums; Latin for 'little brain') is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as it or eve ...

and

. It is supplied by the following arteries: *

Vertebral arteries The vertebral arteries are major arteries of the neck. Typically, the vertebral arteries originate from the subclavian arteries. Each vessel courses superiorly along each side of the neck, merging within the skull to form the single, midline ...

: These smaller arteries branch from the

subclavian arteries In human anatomy, the subclavian arteries are paired major arteries of the upper thorax, below the clavicle. They receive blood from the aortic arch. The left subclavian artery supplies blood to the left arm and the right subclavian artery supplie ...

which primarily supply the shoulders, lateral chest, and arms. Within the

cranium The skull, or cranium, is typically a bony enclosure around the brain of a vertebrate. In some fish, and amphibians, the skull is of cartilage. The skull is at the head end of the vertebrate. In the human, the skull comprises two prominent ...

the two vertebral arteries fuse into the

basilar artery The basilar artery (U.K.: ; U.S.: ) is one of the arteries that supplies the brain with oxygen-rich blood. The two vertebral arteries and the basilar artery are known as the vertebral basilar system, which supplies blood to the posterior part o ...

. **

Posterior inferior cerebellar artery The posterior inferior cerebellar artery (PICA) is the largest branch of the vertebral artery. It is one of the three main arteries that supply blood to the cerebellum, a part of the brain. Blockage of the posterior inferior cerebellar artery can ...

(PICA) *

Basilar artery The basilar artery (U.K.: ; U.S.: ) is one of the arteries that supplies the brain with oxygen-rich blood. The two vertebral arteries and the basilar artery are known as the vertebral basilar system, which supplies blood to the posterior part o ...

: Supplies the

midbrain The midbrain or mesencephalon is the uppermost portion of the brainstem connecting the diencephalon and cerebrum with the pons. It consists of the cerebral peduncles, tegmentum, and tectum. It is functionally associated with vision, hearing, mo ...

, and usually branches into the

posterior cerebral artery The posterior cerebral artery (PCA) is one of a pair of cerebral arteries that supply oxygenated blood to the occipital lobe, as well as the medial and inferior aspects of the temporal lobe of the human brain. The two arteries originate from the d ...

Anterior inferior cerebellar artery The anterior inferior cerebellar artery (AICA) is one of three pairs of artery, arteries that supplies blood to the cerebellum. It arises from the basilar artery on each side at the level of the junction between the medulla oblongata and the pons ...

(AICA) ** Pontine branches **

Superior cerebellar artery The superior cerebellar artery (SCA) is an artery of the head. It arises near the end of the basilar artery. It is a branch of the basilar artery. It supplies parts of the cerebellum, the midbrain, and other nearby structures. It is the cause of t ...

(SCA) *

Posterior cerebral artery The posterior cerebral artery (PCA) is one of a pair of cerebral arteries that supply oxygenated blood to the occipital lobe, as well as the medial and inferior aspects of the temporal lobe of the human brain. The two arteries originate from the d ...

(PCA) *

Posterior communicating artery In human anatomy, the left and right posterior communicating arteries are small arteries at the base of the brain that form part of the circle of Willis. Anteriorly, it unites with the internal carotid artery (ICA) (prior to the terminal bifurcat ...

Venous drainage

The venous drainage of the cerebrum can be separated into two subdivisions: superficial and deep. ;The superficial system The superficial system is composed of

dural venous sinuses The dural venous sinuses (also called dural sinuses, cerebral sinuses, or cranial sinuses) are venous sinuses (channels) found between the periosteal and meningeal layers of dura mater in the brain. They receive blood from the cerebral veins, ...

sinuses Paranasal sinuses are a group of four paired air-filled spaces that surround the nasal cavity. The maxillary sinuses are located under the eyes; the frontal sinuses are above the eyes; the ethmoidal sinuses are between the eyes and the sphenoi ...

(channels) within the dura mater. The dural sinuses are therefore located on the surface of the cerebrum. The most prominent of these sinuses is the

superior sagittal sinus The superior sagittal sinus (also known as the superior longitudinal sinus), within the human head, is an unpaired dural venous sinus lying along the attached margin of the falx cerebri. It allows blood to drain from the lateral aspects of the a ...

which is located in the sagittal plane under the midline of the cerebral vault, posteriorly and inferiorly to the

confluence of sinuses The confluence of sinuses (Latin: confluens sinuum), torcular Herophili, or torcula is the connecting point of the superior sagittal sinus, straight sinus, and occipital sinus. It is below the internal occipital protuberance of the skull. It dra ...

, where the superficial drainage joins with the sinus that primarily drains the deep venous system. From here, two

transverse sinuses The transverse sinuses (left and right lateral sinuses), within the human head, are two areas beneath the brain which allow blood to drain from the back of the head. They run laterally in a groove along the interior surface of the occipital bone ...

bifurcate and travel laterally and inferiorly in an S-shaped curve that forms the

sigmoid sinuses The sigmoid sinuses (sigma- or s-shaped hollow curve), also known as the , are paired dural venous sinuses within the skull that receive blood from posterior transverse sinuses. Structure The sigmoid sinus is a dural venous sinus situated within ...

which go on to form the two

jugular vein The jugular veins () are veins that take blood from the head back to the heart via the superior vena cava. The internal jugular vein descends next to the internal carotid artery and continues posteriorly to the sternocleidomastoid muscle. Struc ...

s. In the neck, the

s parallel the upward course of the

carotid arteries In anatomy, the left and right common carotid arteries (carotids) () are arteries that supply the head and neck with oxygenated blood; they divide in the neck to form the external and internal carotid arteries. Structure The common carotid ...

and drain blood into the

superior vena cava The superior vena cava (SVC) is the superior of the two venae cavae, the great venous trunks that return deoxygenated blood from the systemic circulation to the right atrium of the heart. It is a large-diameter (24 mm) short length vei ...

. The veins puncture the relevant dural sinus, piercing the arachnoid and dura mater as bridging veins that drain their contents into the sinus. ;The deep venous system The deep venous system is primarily composed of traditional

inside the deep structures of the brain, which join behind the midbrain to form the

great cerebral vein The great cerebral vein is one of the large blood vessels in the skull draining the cerebrum of the brain. It is also known as the vein of Galen, named for its discoverer, the Greek physician Galen. Structure The great cerebral vein is one of th ...

(vein of Galen). This vein merges with the

inferior sagittal sinus The inferior sagittal sinus (also known as inferior longitudinal sinus), within the human head, is an area beneath the brain which allows blood to drain outwards posteriorly from the center of the head. It drains (from the center of the brain) to ...

to form the

straight sinus The straight sinus, also known as tentorial sinus or the , is an area within the skull beneath the brain. It receives blood from the inferior sagittal sinus and the great cerebral vein, and drains into the confluence of sinuses. Structure The ...

which then joins the superficial venous system mentioned above at the

Maturation of cerebral blood vessels

The maturation of blood vessels in the brain is a critical process that occurs postnatally. It involves the acquisition of key barrier and contractile properties essential for brain function. During the early postnatal phase,

endothelial cell The endothelium (: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and th ...

s (ECs) and

vascular smooth muscle cell Vascular smooth muscle is the type of smooth muscle that makes up most of the walls of blood vessels. Structure Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood v ...

s (VSMCs) undergo significant molecular and functional changes. Endothelial cells begin to express

P-glycoprotein P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein ...

, a crucial efflux transporter that helps protect the brain by expelling harmful substances. This efflux capacity is progressively acquired and becomes fully functional by the postnatal period. Additionally, VSMCs, which initially populate the arterial network, start to express contractile proteins such as smooth muscle

actin Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ...

(SMA) and

myosin-11 Myosin-11 is a protein that in humans is encoded by the ''MYH11'' gene. Function Myosin-11 is a smooth muscle myosin belonging to the myosin heavy chain family. Myosin-11 is a subunit of a hexameric protein that consists of two heavy chain sub ...

, transforming VSMCs into contractile cells capable of regulating blood vessel tone and cerebral blood flow. The expression of Myh11 in VSMCs acts as a developmental switch, with significant upregulation occurring from birth to the age of 2 to 5 years. This is a critical period needed for the establishment of vessel contractility and the overall functionality of the cerebral circulation.

Physiology

Cerebral blood flow (CBF) is the blood supply to the

in a given period of time. In an adult, CBF is typically 750 millilitres per minute or 15.8 ± 5.7% of the

. This equates to an average

perfusion Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ (anatomy), organ or a tissue (biology), tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion may also refer t ...

of 50 to 54 millilitres of blood per 100 grams of brain tissue per minute. The ratio index of cerebral blood flow/cardiac output (CCRI) decreases by 1.3% per decade, even though cardiac output remains unchanged. Across the adult lifespan, women have a higher CCRI than men. CBF is inversely associated with

body mass index Body mass index (BMI) is a value derived from the mass (Mass versus weight, weight) and height of a person. The BMI is defined as the human body weight, body mass divided by the square (algebra), square of the human height, body height, and is ...

. CBF is tightly regulated to meet the brain's

demands. Too much blood (a clinical condition of a normal homeostatic response of

hyperemia Hyperaemia (also hyperemia) is the increase of blood flow to different tissues in the body. It can have medical implications but is also a regulatory response, allowing change in blood supply to different tissues through vasodilation (widenin ...

) can raise

intracranial pressure Intracranial pressure (ICP) is the pressure exerted by fluids such as cerebrospinal fluid (CSF) inside the skull and on the brain tissue. ICP is measured in millimeters of mercury ( mmHg) and at rest, is normally 7–15 mmHg for a supine adu ...

(ICP), which can compress and damage delicate brain tissue. Too little blood flow (

ischemia Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems ...

) results if blood flow to the brain is below 18 to 20 ml per 100 g per minute, and tissue death occurs if flow dips below 8 to 10 ml per 100 g per minute. In brain tissue, a

biochemical cascade A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions that occur within a biological cell when initiated by a stimulus. This stimulus, known as a first messenger, acts on a receptor that ...

known as the

ischemic cascade The ischemic (ischaemic) cascade is a series of biochemical reactions that are initiated in the brain and other aerobic tissues after seconds to minutes of ischemia (inadequate blood supply). This is typically secondary to stroke, injury, or cardia ...

is triggered when the tissue becomes ischemic, potentially resulting in damage to and the death of

brain cells Brain cells make up the functional tissue of the brain. The rest of the brain tissue is the structural stroma that includes connective tissue such as the meninges, blood vessels, and ducts. The two main types of cells in the brain are neurons, ...

. Medical professionals must take steps to maintain proper CBF in patients who have conditions like

shock Shock may refer to: Common uses Healthcare * Acute stress reaction, also known as psychological or mental shock ** Shell shock, soldiers' reaction to battle trauma * Circulatory shock, a medical emergency ** Cardiogenic shock, resulting from ...

cerebral edema Cerebral edema is excess accumulation of fluid ( edema) in the intracellular or extracellular spaces of the brain. This typically causes impaired nerve function, increased pressure within the skull, and can eventually lead to direct compres ...

, and

traumatic brain injury A traumatic brain injury (TBI), also known as an intracranial injury, is an injury to the brain caused by an external force. TBI can be classified based on severity ranging from mild traumatic brain injury (mTBI/concussion) to severe traumati ...

. Cerebral blood flow is determined by a number of factors, such as

viscosity Viscosity is a measure of a fluid's rate-dependent drag (physics), resistance to a change in shape or to movement of its neighboring portions relative to one another. For liquids, it corresponds to the informal concept of ''thickness''; for e ...

of blood, how dilated

s are, and the net pressure of the flow of blood into the brain, known as

cerebral perfusion pressure Cerebral perfusion pressure, or CPP, is the net pressure gradient causing cerebral blood flow to the brain (brain perfusion). It must be maintained within narrow limits because too little pressure could cause brain tissue to become ischemic (havin ...

, which is determined by the body's

blood pressure Blood pressure (BP) is the pressure of Circulatory system, circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term ...

. Cerebral perfusion pressure (CPP) is defined as the mean arterial pressure (MAP) minus the intracranial pressure (ICP). In normal individuals, it should be above 50 mm Hg. Intracranial pressure should not be above 15 mm Hg (ICP of 20 mm Hg is considered as intracranial hypertension). Cerebral blood vessels are able to change the flow of blood through them by altering their diameters in a process called

cerebral autoregulation Cerebral autoregulation is a process in mammals that aims to maintain adequate and stable cerebral blood flow. While most systems of the body show some degree of autoregulation, the brain is very sensitive to over- and underperfusion. Cerebral auto ...

; they constrict when systemic blood pressure is raised and dilate when it is lowered. Arterioles also constrict and dilate in response to different chemical concentrations. For example, they dilate in response to higher levels of

in the blood and constrict in response to lower levels of carbon dioxide. For example, assuming a person with an arterial partial pressure of carbon dioxide (

PaCO2 ''p''CO2, pCO2, or P_\ce is the partial pressure of carbon dioxide (CO2), often used in reference to blood but also used in meteorology, climate science, oceanography, and limnology to describe the fractional pressure of CO2 as a function of its ...

) of 40 mmHg (normal range of 38–42 mmHg) and a CBF of 50 ml per 100g per min. If the PaCO2 dips to 30 mmHg, this represents a 10 mmHg decrease from the initial value of PaCO2. Consequently, the CBF decreases by 1ml per 100g per min for each 1mmHg decrease in PaCO2, resulting in a new CBF of 40ml per 100g of brain tissue per minute. In fact, for each 1 mmHg increase or decrease in PaCO2, between the range of 20–60 mmHg, there is a corresponding CBF change in the same direction of approximately 1–2 ml/100g/min, or 2–5% of the CBF value. This is why small alterations in respiration pattern can cause significant changes in global CBF, specially through PaCO2 variations. CBF is equal to the

(CPP) divided by the cerebrovascular resistance (CVR): :CBF = CPP / CVR Control of CBF is considered in terms of the factors affecting CPP and the factors affecting CVR. CVR is controlled by four major mechanisms: #

Metabolic Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the ...

control (or 'metabolic autoregulation') # Pressure

# Chemical control (by arterial pCO₂ and pO₂) #

Neural In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes t ...

control

Role of intracranial pressure

Increased

(ICP) causes decreased blood perfusion of

brain cell Brain cells make up the functional tissue of the brain. The rest of the brain tissue is the structural stroma that includes connective tissue such as the meninges, blood vessels, and ducts. The two main types of cells in the brain are neurons, ...

s by mainly two mechanisms: * Increased ICP constitutes an increased

interstitial hydrostatic pressure {{Short pages monitor