Bivariate Von Mises Distribution
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In
probability theory Probability theory or probability calculus is the branch of mathematics concerned with probability. Although there are several different probability interpretations, probability theory treats the concept in a rigorous mathematical manner by expre ...
and
statistics Statistics (from German language, German: ', "description of a State (polity), state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a s ...
, the bivariate von Mises distribution is a
probability distribution In probability theory and statistics, a probability distribution is a Function (mathematics), function that gives the probabilities of occurrence of possible events for an Experiment (probability theory), experiment. It is a mathematical descri ...
describing values on a
torus In geometry, a torus (: tori or toruses) is a surface of revolution generated by revolving a circle in three-dimensional space one full revolution about an axis that is coplanarity, coplanar with the circle. The main types of toruses inclu ...
. It may be thought of as an analogue on the torus of the
bivariate normal distribution In probability theory and statistics, the multivariate normal distribution, multivariate Gaussian distribution, or joint normal distribution is a generalization of the one-dimensional ( univariate) normal distribution to higher dimensions. One d ...
. The distribution belongs to the field of
directional statistics Directional statistics (also circular statistics or spherical statistics) is the subdiscipline of statistics that deals with directions (unit vectors in Euclidean space, R''n''), axes ( lines through the origin in R''n'') or rotations in R''n''. ...
. The general bivariate von Mises distribution was first proposed by Kanti Mardia in 1975. One of its variants is today used in the field of
bioinformatics Bioinformatics () is an interdisciplinary field of science that develops methods and Bioinformatics software, software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, ...
to formulate a probabilistic model of
protein structure Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers specifically polypeptides formed from sequences of amino acids, which are the monomers of the polymer. A single amino acid ...
in atomic detail, such as backbone-dependent rotamer libraries.


Definition

The bivariate von Mises distribution is a
probability distribution In probability theory and statistics, a probability distribution is a Function (mathematics), function that gives the probabilities of occurrence of possible events for an Experiment (probability theory), experiment. It is a mathematical descri ...
defined on the
torus In geometry, a torus (: tori or toruses) is a surface of revolution generated by revolving a circle in three-dimensional space one full revolution about an axis that is coplanarity, coplanar with the circle. The main types of toruses inclu ...
, S^1 \times S^1 in \mathbb^3. The probability density function of the general bivariate von Mises distribution for the angles \phi, \psi \in , 2\pi/math> is given by : f(\phi, \psi) \propto \exp \kappa_1 \cos(\phi - \mu) + \kappa_2 \cos(\psi - \nu) + (\cos(\phi-\mu), \sin(\phi-\mu)) \mathbf (\cos(\psi - \nu), \sin(\psi - \nu))^T where \mu and \nu are the means for \phi and \psi, \kappa_1 and \kappa_2 their concentration and the matrix \mathbf \in \mathbb(2,2) is related to their correlation. Two commonly used variants of the bivariate von Mises distribution are the sine and cosine variant. The cosine variant of the bivariate von Mises distribution has the probability density function : f(\phi, \psi) = Z_c(\kappa_1, \kappa_2, \kappa_3) \ \exp \kappa_1 \cos(\phi - \mu) + \kappa_2 \cos(\psi - \nu) - \kappa_3 \cos(\phi - \mu - \psi + \nu) where \mu and \nu are the means for \phi and \psi, \kappa_1 and \kappa_2 their concentration and \kappa_3 is related to their correlation. Z_c is the normalization constant. This distribution with \kappa_3=0 has been used for kernel density estimates of the distribution of the protein dihedral angles \phi and \psi. The sine variant has the probability density function : f(\phi, \psi) = Z_s(\kappa_1, \kappa_2, \kappa_3) \ \exp \kappa_1 \cos(\phi - \mu) + \kappa_2 \cos(\psi - \nu) + \kappa_3 \sin(\phi - \mu) \sin(\psi - \nu) where the parameters have the same interpretation.


See also

*
Von Mises distribution In probability theory and directional statistics, the Richard von Mises, von Mises distribution (also known as the circular normal distribution or the Andrey Nikolayevich Tikhonov, Tikhonov distribution) is a continuous probability distribution ...
, a similar distribution on the one-dimensional unit circle * Kent distribution, a related distribution on the two-dimensional unit sphere * von Mises–Fisher distribution *
Directional statistics Directional statistics (also circular statistics or spherical statistics) is the subdiscipline of statistics that deals with directions (unit vectors in Euclidean space, R''n''), axes ( lines through the origin in R''n'') or rotations in R''n''. ...


References

{{ProbDistributions, directional Continuous distributions Directional statistics Multivariate continuous distributions