Biotin/lipoyl attachment
domain
A domain is a geographic area controlled by a single person or organization. Domain may also refer to:
Law and human geography
* Demesne, in English common law and other Medieval European contexts, lands directly managed by their holder rather ...
has a conserved lysine residue that binds
biotin
Biotin (also known as vitamin B7 or vitamin H) is one of the B vitamins. It is involved in a wide range of metabolic processes, both in humans and in other organisms, primarily related to the utilization of fats, carbohydrates, and amino acids. ...
or
lipoic acid
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). ALA, which is made in animals normally, is essential for aerobic metabolism. It i ...
. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme.
s have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group.
The lipoic acid cofactor is found in a variety of proteins.
Human proteins containing this domain
ACACA
Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ''ACACA'' gene.
Function
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which ...
;
ACACB;
DBT;
DLAT;
DLST;
DLSTP;
MCCC1;
PC;
PCCA;
PDHX;
References
{{DEFAULTSORT:Biotin Attachment Domain
Protein domains