Bernstein Network Computational Neuroscience
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The Bernstein Network is a research network in the field of
computational neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of  neuroscience which employs mathematics, computer science, theoretical analysis and abstractions of the brain to understand th ...
; this field brings together experimental approaches in
neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...
with theoretical models and
computer simulation Computer simulation is the running of a mathematical model on a computer, the model being designed to represent the behaviour of, or the outcome of, a real-world or physical system. The reliability of some mathematical models can be determin ...
s. It unites different scientific disciplines, such as physics, biology, mathematics, medical science, psychology, computer science, engineering and philosophy in the endeavor to understand how the brain functions. The close combination of neurobiological experiments with theoretical models and computer simulations allows scientists of the Bernstein Network to pursue innovative approaches with regard to one of the most complex structures nature has created in the course of evolution: the natural brain. The network started in 2004 with a funding initiative of the Federal Ministry of Education and Research (BMBF) to develop and interconnect research structures in computational neuroscience throughout Germany and to promote the transfer of theoretical insight into clinical and technical applications. It is named after the German physiologist and biophysicist
Julius Bernstein Julius Bernstein (18 December 1839 – 6 February 1917) was a German physiologist born in Berlin. His father was Aaron Bernstein (1812–1884), a founder of the Reform Judaism Congregation in Berlin 1845; his son was the mathematician Felix Ber ...
(1839–1917). His "membrane hypothesis" provided the first biophysical explanation of how nerve cells transmit and process information via electrical currents. Generating a mathematical description, he also paved the way to simulate neural brain processes in the computer. Today, the Bernstein Network consists of more than 200 research groups worldwide.


History

In 2004, the Bernstein Network started off as the "Nationales Bernstein Netzwerk Computational Neuroscience" (NNCN)) as a funding initiative of the Federal Ministry of Education and Research (BMBF). The aim of the initiative was the long-term establishment of the research discipline
Computational Neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of  neuroscience which employs mathematics, computer science, theoretical analysis and abstractions of the brain to understand th ...
in Germany. As part of the high-tech strategy of the German government, the Bernstein Network has been supported with a total of about 170 million euros until now. The network includes over 200 research groups at more than 25 locations nationwide. The participating research groups were located at universities and non-university research institutes (Fraunhofer, Helmholtz, Leibniz and Max Planck institutes). Using a BMBF initial financing, 22 new professorships in the area of Computational Neuroscience were established at German universities within the framework of the Bernstein Network, which were cnsoblidated by the federal states. Scientific members of the network were involved in study programs and courses and collaborated with numerous industry partners to develop specific biomedical or technological applications (e.g.
brain computer interface The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head ( cephalization), usually near organs for special sen ...
,
retinal implant A retinal implant is a visual prosthesis for restoration of sight to patients blinded by retinal degeneration. The system is meant to partially restore useful vision to those who have lost their photoreceptors due to retinal diseases such as retin ...
,
cochlear implant A cochlear implant (CI) is a surgically implanted Neuroprosthetics, neuroprosthesis that provides a person who has moderate-to-profound sensorineural hearing loss with sound perception. With the help of therapy, cochlear implants may allow for imp ...
,
prosthesis In medicine, a prosthesis (: prostheses; from ), or a prosthetic implant, is an artificial device that replaces a missing body part, which may be lost through physical trauma, disease, or a condition present at birth (Congenital, congenital disord ...
,
advanced driver-assistance systems Advanced driver-assistance systems (ADAS) are technologies that assist drivers with the safe operation of a vehicle. Through a human-machine interface, ADAS increases car and road safety. ADAS uses automated technology, such as sensors and camer ...
,
neuromorphic Neuromorphic computing is an approach to computing that is inspired by the structure and function of the human brain. A neuromorphic computer/chip is any device that uses physical artificial neurons to do computations. In recent times, the term ...
chips). They also worked (and still do) on new diagnostic methods, therapeutic approaches, or tools for neurological or psychiatric disorders in collaboration with clinical researchers (e.g.
epilepsy Epilepsy is a group of Non-communicable disease, non-communicable Neurological disorder, neurological disorders characterized by a tendency for recurrent, unprovoked Seizure, seizures. A seizure is a sudden burst of abnormal electrical activit ...
,
tinnitus Tinnitus is a condition when a person hears a ringing sound or a different variety of sound when no corresponding external sound is present and other people cannot hear it. Nearly everyone experiences faint "normal tinnitus" in a completely ...
,
amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or—in the United States—Lou Gehrig's disease (LGD), is a rare, Terminal illness, terminal neurodegenerative disease, neurodegenerative disorder that results i ...
,
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...
,
stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...
, depression,
schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...
).


Structure

Six Bernstein Centers (in Berlin,
Freiburg Freiburg im Breisgau or simply Freiburg is the List of cities in Baden-Württemberg by population, fourth-largest city of the German state of Baden-Württemberg after Stuttgart, Mannheim and Karlsruhe. Its built-up area has a population of abou ...
, Göttingen, Heidelberg-Mannheim, Munich and Tübingen) form the basic structure of the Bernstein Network. As additional local structural elements, five Bernstein groups have been established (in Bochum, Bremen, Heidelberg, Jena, and Magdeburg). Eleven Bernstein Collaborations link the Bernstein Centers with diverse research groups widely distributed over Germany. Since 2006, the BMBF has annually allocated the Bernstein Award to an outstanding young scientist in the research field of Computational Neuroscience. The award is endowed with up to 1,25 million euros over five years, and allows to establish an independent junior research group at a German research institution. Since 2008 and 2009, respectively, the Bernstein Network comprehends two research foci, which explore the first steps towards applications. The'' Bernstein Focus: Neurotechnology'' includes 4 local collaborative projects (in Berlin, Göttingen, Frankfurt and Freiburg-Tübingen); the'' Bernstein Focus: Neuronal Basis of Learning'' comprises eight collaborative projects.


Integration into the international research landscape

The German INCF Node (G-Node) connects the Bernstein Network with the international network of the International Neuroinformatics Coordinating Facility. Since 2010, the
BMBF The Federal Ministry of Research, Technology and Space (; abbreviated BMFTR) is a cabinet-level ministry of Germany. It is headquartered in Bonn, with an office in Berlin. The Ministry provides funding for research projects and institutions (aim ...
promotes German-American cooperation projects in the field of computational neuroscience within the framework of the Bernstein Network and the CRCNS program in cooperation with the
National Science Foundation (NSF) The U.S. National Science Foundation (NSF) is an independent agency of the United States federal government that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is ...
and the National Institutes of Health (NIH). In a cooperation between the
BMBF The Federal Ministry of Research, Technology and Space (; abbreviated BMFTR) is a cabinet-level ministry of Germany. It is headquartered in Bonn, with an office in Berlin. The Ministry provides funding for research projects and institutions (aim ...
, German Research Foundation (DFG), and the
Japan Science and Technology Agency The Japan Science and Technology Agency (JST; Japanese: 科学技術振興機構) is a Japanese government agency which aims to build infrastructure that supports knowledge creation and dissemination in Japan. It is one of the National Research an ...
(JST), German-Japan Collaboration projects have been launched in 2012.


Bernstein Conference

Th
Bernstein Conference
is the largest annual Computational Neuroscience conference in Europe attracting an international audience from across the world. Until 2017, it was organized by members of the Bernstein Network at annually changing locations. In the years 2018 - 2022, the Bernstein Conferences takes place in Berlin. The conference offers a broad overview over the topics of Computational Neuroscience and Neurotechnology.


Membership

In 2009, members of the Bernstein Network founded a non-profit association, the Bernstein Association Computational Neuroscience, aiming at promoting science, research, and teaching in
Computational Neuroscience Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of  neuroscience which employs mathematics, computer science, theoretical analysis and abstractions of the brain to understand th ...
and the communication of research contents and results to the public.Website of Bernstein Association Computational Neuroscience
/ref> The Bernstein Network Computational Neuroscience is open to all researchers in the field or related subjects. Individual membership must be supported by two active Bernstein members
Further information.


Literature

*
Peter Dayan Peter Dayan is a British neuroscientist and computer scientist who is director at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany, along with Ivan De Araujo. He is co-author of ''Theoretical Neuroscience'', an influent ...
, Larry F. Abbott: "Theoretical neuroscience: computational and mathematical modeling of neural systems". MIT Press, Cambridge, Mass 2001, . *
William Bialek William Samuel Bialek (born 14 August 1960) is a theoretical biophysicist and a professor at Princeton University and The Graduate Center, CUNY. Much of his work, which has ranged over a wide variety of theoretical problems at the interface of p ...
, Fred Rieke, David Warland, Rob de Ruyter van Steveninck: "Spikes: exploring the neural code". MIT Press, Cambridge, Mass 1999, . *David Sterratt, Bruce Graham, Andrew Gillies, David Willshaw: "Principles of Computational Modelling in Neuroscience". Cambridge University Press, 2011, * Sonja Grün, Stefan Rotter (eds.): „Analysis of Parallel Spike Trains“, Springer Series in Computational Neuroscience, 2010. * Hanspeter A. Mallot: "Computational Neuroscience: A first course", Springer Series in Bio-/Neuroinformatics, 2013. *
James M. Bower James Mason Bower (born February 17, 1954) is an American neuroscientist and Chief executive officer, CEO and chairman of the Board of Numedeon Inc., creator of the Whyville.net educational virtual world. He graduated from McQuaid Jesuit High Sc ...
(ed.): "20 years of Computational Neuroscience", Springer Series in Computational Neuroscience, 2013.


Links


Website of the Bernstein Network Computational NeuroscienceWebsite of the Bernstein ConferenceGerman Neuroinformatics Node of the INCF (G-Node)International Neuroinformatics Coordinating Facility (INCF)


References

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