Bepridil (trade name Vascor) is an
diamine calcium channel blocker once used to treat
angina pectoris. It is no longer sold in the United States.
It is nonselective.
It has been discussed as a possible option in the treatment of
atrial fibrillation.
It has been implicated in causing ventricular arrhythmia (
torsades de pointes).
Ebola research
In June 2015 a research paper was published finding bepridil to result in a 100% survival rate for mice exposed to
ebola
Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after in ...
during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.
SARS-CoV-2 research
A research paper
showed that Bepridil inhibited cytopathogenic effects induced by
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional nam ...
in Vero E6 cells and in A549 cells in an in vitro assay.
References
External links
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Calcium channel blockers
1-Pyrrolidinyl compounds
Amines
Ethers
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