Benzotript (), also known as ''N''-(''p''-chlorobenzoyl)-L-tryptophan, is a

muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeu ...

that inhibits

gastric The stomach is a muscular, hollow organ in the upper gastrointestinal tract of humans and many other animals, including several invertebrates. The Ancient Greek name for the stomach is ''gaster'' which is used as ''gastric'' in medical terms re ...

secretion Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland. In contrast, excretion is the removal of certain substances or waste products from a cell or organism. The classical mec ...

and was never marketed. It is a

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...

derivative In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...

and the ''N''-(4-chlorobenzoyl) analogue of the

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...

tryptophan Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins. Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromat ...

. Similarly to

proglumide Proglumide, sold under the brand name Milid, is a drug that inhibits gastrointestinal motility Motility is the ability of an organism to move independently using metabolism, metabolic energy. This biological concept encompasses movement at v ...

(''N''²-benzoyl-''N'',''N''-dipropyl-α-glutamine), the drug acts as a

competitive Competition is a rivalry where two or more parties strive for a common goal which cannot be shared: where one's gain is the other's loss (an example of which is a zero-sum game). Competition can arise between entities such as organisms, indi ...

and non-selective cholecystokinin receptor antagonist. Other more potent tryptophan derivatives have also been developed as cholecystokinin (CCK) antagonists.

References

4-Chlorophenyl compounds Abandoned drugs Amino acids Cholecystokinin antagonists Muscle relaxants N-Acyltryptamines {{Gastrointestinal-drug-stub