An atypical antidepressant is any
antidepressant medication
Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to medical diagnosis, diagnose, cure, treat, or preventive medicine, prevent disease. Drug therapy (pharmaco ...
that acts in a manner that is different from that of most other antidepressants.
Atypical antidepressants include:
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agomelatine
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bupropion
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iprindole
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opipramol
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tianeptine
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mianserin
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mirtazapine
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trazodone
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nefazodone
The agents
vilazodone and
vortioxetine are partly atypical.
Typical antidepressants include the
SSRIs,
SNRIs,
TCAs, and
MAOIs, which act mainly by increasing the levels of the
monoamine neurotransmitters
serotonin and/or
norepinephrine.
Among TCAs,
trimipramine is an atypical agent in that it appears not to do this.
In August 2020,
esketamine (JNJ-54135419) was approved by the U.S.
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
(FDA) for the treatment of
treatment-resistant depression with the added indication for the short-term treatment of suicidal thoughts.
(ALKS-5461) is an antidepressant with a novel
mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical Drug interaction, interaction through which a Medication, drug substance produces its pharmacological effect. A mechanism of action usually includes mention o ...
which was formerly under development and considered an atypical antidepressant.
They act faster than available
antidepressants.
See also
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Second-generation antidepressant
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Pharmacology of antidepressants
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List of antidepressants
References
Antidepressants
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