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Acrogeria (Gottron's syndrome) is a skin condition characterized by premature aging, typically in the form of unusually fragile, thin skin on the hands and feet (distal extremities). This is one of the classic
congenital A birth defect is an abnormal condition that is present at childbirth, birth, regardless of its cause. Birth defects may result in disability, disabilities that may be physical disability, physical, intellectual disability, intellectual, or dev ...
premature aging syndromes, occurring early in life, others being pangeria ( Werner's syndrome) and progeria (Hutchinson–Gilford's syndrome), and was characterized in 1940.Gottron, H. Familiaere Akrogerie. Arch. Derm. Syph. 181: 571-583, 1940. Acrogeria was originally described by Gottron in 1941, when he noticed premature cutaneous aging localized on the hands and feet in two brothers. The problem had been present since birth. Onset is often in early childhood, it progresses over the next few years and then remains stable over time with morphology, colour and site remaining constant. A bruising tendency has been observed. Mutations in the COL3A1 gene, located at chromosome 2q31–q32, have been reported in varied phenotypes, including acrogeria and vascular rupture in Ehlers-Danlos' syndrome (more especially type IV).


See also

* Hutchinson–Gilford syndrome *
List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ...


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Familial acrogeria in a brother and sister
{{Disorders involving multiple endocrine glands Genodermatoses Genetic disorders with OMIM but no gene Rare diseases