AM-906 (part of the AM cannabinoid series) is an

analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...

drug which is a cannabinoid

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB₁ and CB₂ receptors. It is a potent and selective agonist for the CB₁ cannabinoid

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

, with a ''K''_i of 0.8 nM at CB₁ and 9.5 nM at CB₂, a selectivity of almost 12x. The corresponding ''E'' or trans isomer is AM-905.

References

Benzochromenes Primary alcohols Phenols AM cannabinoids {{cannabinoid-stub

See also

References