AFDX-384 (BIBN-161) is a drug which acts as a selective

antagonist An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.muscarinic acetylcholine receptor Muscarinic acetylcholine receptors (mAChRs) are acetylcholine receptors that form G protein-coupled receptor, G protein-coupled receptor complexes in the cell membranes of certain neurons and other Cell (biology), cells. They play several role ...

s, with selectivity for the M₂ and M₄ subtypes. It is used mainly for mapping the distribution of M₂ and M₄ muscarinic receptors in the brain, and studying their involvement in the development and treatment of

dementia Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform activities of daily living, everyday activities. This typically invo ...

and

schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...

References

{{Muscarinic acetylcholine receptor modulators Dipropylamino compounds M2 receptor antagonists M4 receptor antagonists Piperidines Pyridobenzodiazepines Ureas

See also

References