ADB-FUBIATA (AD-18, FUB-ACADB, ADB-FUBIACA) is a

synthetic cannabinoid Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthetic ...

compound first identified in 2021. It is closely related in structure to the older compound

ADB-FUBICA ADB-FUBICA is a drug that acts as a potent agonist for the cannabinoid receptors, with EC50 values of 2.6 nM at CB1 and 3.0 nM at CB2. See also * AB-FUBICA * AB-FUBINACA AB-FUBINACA is a drug that acts as a potent agonist for the cannabin ...

but with the amide linker group extended by the addition of a methylene bridge. It started to be sold as an ingedient in grey-market synthetic cannabis blends following the introduction of legislation in China which for the first time introduced general controls on various classes of synthetic cannabinoids, but did not encompass compounds where the linker group had been extended in this fashion. ADB-FUBIATA has many times lower affinity for cannabinoid receptors than ADB-FUBICA with an EC₅₀ of only 635 nM at CB₁, but retains full agonist activity at this target, while being practically inactive at CB₂.

References

Cannabinoids Indoles Fluoroarenes Amides Carboxamides {{cannabinoid-stub