AB-PINACA is a compound that was first identified as a component of
synthetic cannabis products in Japan in 2012.
It was originally developed by
Pfizer
Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...
in 2009 as an
analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...
medication.
AB-PINACA acts as a potent
agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
for the
CB1 receptor (''K''
i = 2.87 nM,
EC50 = 1.2 nM) and
CB2 receptor (''K''
i = 0.88 nM, EC
50 = 2.5 nM) and fully substitutes for
Δ9-THC in rat discrimination studies, while being 1.5x more potent.
There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.
Legal status
Germany
AB-PINACA is an
Anlage II controlled substance in
Germany
Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total popu ...
as of November 2014.
Singapore
It is listed in the Fifth Schedule of the Misuse of Drugs Act and so is illegal in
Singapore
Singapore, officially the Republic of Singapore, is an island country and city-state in Southeast Asia. The country's territory comprises one main island, 63 satellite islands and islets, and one outlying islet. It is about one degree ...
, as of May 2015.
United States
It is a
Schedule I controlled substance in the
United States
The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...
.
China
It is a controlled substance in
China
China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the list of countries by population (United Nations), second-most populous country after ...
as of October 2015.
France
It is a controlled substance in
France
France, officially the French Republic, is a country located primarily in Western Europe. Overseas France, Its overseas regions and territories include French Guiana in South America, Saint Pierre and Miquelon in the Atlantic Ocean#North Atlan ...
as of March 2017.
See also
*
5F-AB-PINACA
*
5F-ADB
*
5F-AMB
*
5F-APINACA
*
5F-CUMYL-PINACA
*
AB-CHFUPYCA
*
AB-FUBINACA
*
AB-PICA
*
ADB-CHMINACA
*
ADB-FUBINACA
*
ADB-PINACA
*
ADBICA
*
APICA
*
APINACA
*
MDMB-CHMICA
*
PX-3
References
{{Cannabinoids
Cannabinoids
Designer drugs
Indazolecarboxamides
CB1 receptor agonists
CB2 receptor agonists