A643 may refer to:
*
A643 road
The A643 is a main road between Leeds and Huddersfield in West Yorkshire, England.
Its eastern end is at the Armley Gyratory roundabout on the western edge of Leeds City Centre. The road then goes through:
* Beeston
* Churwell
* Morley
* B ...
, a road in England
*
Bundesautobahn 643, a road in Germany
{{Disambiguation, letter number, road