7-Methyl-α-ethyltryptamine
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7-Methyl-α-ethyltryptamine (7-Me-αET) is a
tryptamine Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...
derivative related to
α-ethyltryptamine α-Ethyltryptamine (αET, AET), also known as etryptamine, is an entactogen and stimulant drug of the tryptamine family. It was originally developed and marketed as an antidepressant under the brand name Monase by Upjohn in the 1960s before bei ...
(αET). It was discovered by a team at
Upjohn The Upjohn Company was an American pharmaceutical manufacturing firm (est. 1886) in Hastings, Michigan, by Dr. William E. Upjohn, an 1875 graduate of the University of Michigan medical school. The company was originally formed to make ''friable ...
in the early 1960s. It has similar pharmacological effects to αET, but is both 3-4 times more potent as a
serotonin releasing agent A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft. A selective serotonin releasing agent (SSRA) is an SRA with less significant or no efficacy in producing neurotransmitter ...
, and 10 times more potent as a
monoamine oxidase inhibitor Monoamine oxidase inhibitors (MAOIs) are a drug class, class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressa ...
, making it potentially hazardous as this pharmacological profile is shared with drugs such as PMA and
4-MTA 4-Methylthioamphetamine (4-MTA), also known as ''para''-methylthioamphetamine (MTA), is a designer drug of the substituted amphetamine class developed in the 1990s by a team led by David E. Nichols, an American pharmacologist and medical chemist, ...
, which are known to be dangerous in humans when used at high doses.


See also

* 4-Methyl-αET * 5-Fluoro-αMT *
5-Fluoro-αET 5-Fluoro-AET, also known as 5-fluoro-α-ethyltryptamine or by the code name PAL-545, is a substituted tryptamine derivative which acts as a serotonin–dopamine releasing agent (SDRA) and as an agonist of the serotonin 5-HT2A receptor. Its val ...
*
7-Methyl-DMT 7,''N'',''N''-trimethyltryptamine (7-methyl-DMT, 7-TMT), is a tryptamine derivative which acts as an agonist of 5-HT2 receptors. In animal tests, both 7-TMT and its 5-methoxy derivative 5-MeO-7-TMT produced behavioural responses similar to thos ...
*
7-Chloro-AMT 7-Chloro-α-methyltryptamine (7-Cl-AMT) is a tryptamine derivative with stimulant effects, invented in the 1960s. It is a weak monoamine oxidase inhibitor but its pharmacology has not otherwise been studied by modern techniques, though several cl ...


References

Alpha-Alkyltryptamines Monoamine oxidase inhibitors Serotonin receptor agonists Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub