7-ACA (7-aminocephalosporanic acid) is the core chemical structure (a
synthon
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J. Corey. He noted in 1988 ...
) for the synthesis of
cephalosporin
The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus '' Acremonium'', which was previously known as ''Cephalosporium''.
Together with cephamycins, they constitute a subgroup of β-lactam antibio ...
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...
s and intermediates. It can be obtained by
chemoenzymatic hydrolysis
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water ...
of
cephalosporin C
Cephalosporin C is an antibiotic of the cephalosporin class. It was isolated from a fungus of the genus '' Acremonium'' and first characterized in 1961. Although not a very active antibiotic itself, synthetic analogs of cephalosporin C, such as ...
.
The production of 7-ACA (7-aminocephalosporanic acid) is predominantly segmented into two methods which is
Enzymatic Hydrolysis
In biochemistry, enzymatic hydrolysis is a process in which enzymes facilitate the cleavage of bonds in molecules with the addition of the elements of water (i.e. hydrolysis). It plays an important role in the digestion of food.
It may be used t ...
and Chemical
Cracking
Cracking may refer to:
* Cracking, the formation of a fracture or partial fracture in a solid material studied as fracture mechanics
** Performing a sternotomy
* Fluid catalytic cracking, a catalytic process widely used in oil refineries for crac ...
. These processes are essential for the synthesis of various
cephalosporin
The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus '' Acremonium'', which was previously known as ''Cephalosporium''.
Together with cephamycins, they constitute a subgroup of β-lactam antibio ...
antibiotics.
See also
*
6-APA
6-APA ((+)-6-aminopenicillanic acid) is an organic compound that is used in the synthesis of β–lactam antibiotics including amoxicillin, ampicillin, oxacillin, and carbenicillin. The major commercial source of 6-APA is natural penicillin G, w ...
References
Cephalosporin antibiotics
Acetate esters
Sulfur heterocycles
{{OrganicAcid-stub