7-AB, also known as 7-amino-6,7,8,9-tetrahydro-5''H''-benzocycloheptene, is a
conformationally restricted analogue of
amphetamine
Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, an ...
related to
2-aminoindane (2-AI) and
2-aminotetralin
2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin core with an amine as substituent.
2-AT is a rigid analogue of phenylisobutylamine and ful ...
(2-AT).
Unlike amphetamine, 2-AI, and 2-AT, 7-AB did not produce
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
-type effects in animals.
Instead, it caused behavioral disruption and death at higher doses.
is a
positional isomer
In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is a compound that contains the same number and type of atoms, but with a different connectivity (i.e. arrangement of bonds) between them. The ...
of 7-AB.
See also
*
2-Amino-1,2-dihydronaphthalene (2-ADN)
*
1-Phenylpiperazine (1-PP)
*
Lorcaserin
Lorcaserin, marketed under the brand name Belviq, was a weight-loss drug developed by Arena Pharmaceuticals. It reduces appetite by activating serotonin receptor the 5-HT2C receptor in the hypothalamus, a region of the brain which is known to ...
References
External links
7-AB - isomer design
Amines
Benzocycloheptenes
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