6-AB, also known as 6-amino-6,7,8,9-tetrahydro-5''H''-benzocycloheptene, is a
conformationally restricted analogue of
amphetamine
Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, an ...
related to
2-aminoindane (2-AI) and
2-aminotetralin
2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin core with an amine as substituent.
2-AT is a rigid analogue of phenylisobutylamine and ful ...
(2-AT).
Unlike amphetamine, 2-AI, and 2-AT, 6-AB did not produce
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
-type effects in animals.
In another study, it produced a biphasic effect at high doses, with initial
hypolocomotion
Locomotor activity is a measure of animal behavior which is employed in scientific research.
Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in whi ...
followed after a few hours by weak
locomotor stimulation.
7-AB
7-AB, also known as 7-amino-6,7,8,9-tetrahydro-5''H''-benzocycloheptene, is a conformationally restricted analogue of amphetamine related to 2-aminoindane (2-AI) and 2-aminotetralin (2-AT). Unlike amphetamine, 2-AI, and 2-AT, 7-AB did not prod ...
is a
positional isomer
In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is a compound that contains the same number and type of atoms, but with a different connectivity (i.e. arrangement of bonds) between them. The ...
of 6-AB.
See also
*
TFMBOX
TFMBOX is a putative serotonergic psychedelic of the phenethylamine and benzoxepin ("BOX") families. It is the cyclized phenethylamine analogue of DOTFM and 2C-TFM in which the α carbon has been connected to the 2-methoxy group via an ethy ...
*
2-Amino-1,2-dihydronaphthalene (2-ADN)
*
1-Phenylpiperazine (1-PP)
References
External links
6-AB - isomer design
Amines
Benzocycloheptenes
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