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The 16th century begins with the Julian calendar, Julian year 1501 (Roman numerals, MDI) and ends with either the Julian or the Gregorian calendar, Gregorian year 1600 (Roman numerals, MDC) (depending on the reckoning used; the Gregorian calendar introduced a lapse of 10 days in October 1582).
The 16th century is regarded by historians as the century which saw the rise of Western culture, Western civilization and the Gunpowder empires, Islamic gunpowder empires. The Renaissance in Italy and Europe saw the emergence of important artists, authors and scientists, and led to the foundation of important subjects which include accounting and political science. Copernicus proposed the Copernican heliocentrism, heliocentric universe, which was met with strong resistance, and Tycho Brahe refuted the theory of celestial spheres through observational measurement of the SN 1572, 1572 appearance of a Milky Way supernova. These events directly challenged the long-held notion of an immutable universe supported by Ptolemy and Aristotle, and led to major revolutions in astronomy and science. Galileo Galilei became a champion of the new sciences, invented the first thermometer and made substantial contributions in the fields of physics and astronomy, becoming a major figure in the Scientific Revolution.
Spain and Portugal colonized large parts of Central America, Central and South America, followed by France and England in Northern America and the Lesser Antilles. The Portuguese became the masters of trade between Brazil, the coasts of Africa, and their possessions in the East Indies, Indies, whereas the Spanish came to dominate the Greater Antilles, Mexico, Peru, and opened trade across the Pacific Ocean, linking the Americas with the Indies. English and French privateers began to practice persistent theft of Spanish and Portuguese treasures. This era of colonialism established mercantilism as the leading school of economic thought, where the economic system was viewed as a zero-sum game in which any gain by one party required a loss by another. The mercantilist doctrine encouraged the many intra-European wars of the period and arguably fueled European Expansionism, expansion and imperialism throughout the world until the 19th century or early 20th century.
The Reformation in central and northern Europe gave a major blow to the authority of the Pope, papacy and the Catholic Church. In Kingdom of England, England, the British-Italian Alberico Gentili wrote the first book on public international law and divided secularism from canon law and Catholic theology. European politics became dominated by religious conflicts, with the groundwork for the epochal Thirty Years' War being laid towards the end of the century.
In the Middle East, the Ottoman Empire continued to expand, with the Sultan taking the title of Caliph, while dealing with a resurgent Persia. Iran and Iraq were caught by a major popularity of the Shia Islam, Shia sect of Islam under the rule of the Safavid dynasty of warrior-mystics, providing grounds for a Persia independent of the majority-Sunni Islam, Sunni Muslim world.
In the Indian subcontinent, following the defeat of the Delhi Sultanate and Vijayanagara Empire, new powers emerged, the Sur Empire founded by Sher Shah Suri, Deccan sultanates, and the Mughal Empire by Emperor Babur, a direct descendant of Timur and Genghis Khan. His successors Humayun and Akbar, enlarged the empire to include most of South Asia. The empire developed a strong and stable economy in the world, leading to commercial expansion and greater patronage of culture, which significantly influenced the course of History of India, Indian history.
Japan suffered a severe civil war at this time, known as the Sengoku period, and emerged from it as a unified nation. China was ruled by the Ming dynasty and came into conflict with Japan and Japanese piracy over the control of Korea.
* 1501: Michelangelo returns to his native Florence to begin work on the statue ''David (Michelangelo), David''.
* 1501: Safavids, Safavid dynasty reunifies Iran and rules over it until 1736. Safavids adopt a Shia Islam, Shia branch of Islam.
* 1501: First Battle of Cannanore between the 3rd Portuguese India Armada (Nova, 1501), Third Portuguese Armada and Kingdom of Cochin under João da Nova and Zamorin of Kozhikode's navy marks the beginning of Portuguese conflicts in the Indian Ocean.
* 1502: First reported Slavery, African slaves in the New World
* 1502: The Crimean Khanate sacks Sarai (city), Sarai in the Golden Horde, ending its existence.
* 1503: Spanish Empire, Spain defeats Early Modern France, France at the Battle of Cerignola. Considered to be the first battle in history won by gunpowder small arms.
* 1503: Leonardo da Vinci begins painting the ''Mona Lisa'' and completes it three years later.
* 1503: Nostradamus is born on either December 14 or December 21.
* 1504: A period of drought, with famine in all of Spain.
* 1504: Death of Isabella I of Castile; Joanna of Castille, Joanna of Castile becomes the Queen.
* 1504: Foundation of the Sultanate of Sennar by Amara Dunqas, in what is modern Sudan
* 1505: Zhengde Emperor ascends the throne of Ming Dynasty.
* 1505: Martin Luther enters St. Augustine's Monastery (Erfurt), St. Augustine's Monastery at Erfurt, Germany, on 17 July and begins his journey to instigating the Reformation.
* 1505: Trenggana, Sultan Trenggono builds the first Muslim kingdom in Java, called Demak Sultanate, Demak, in Indonesia. Many other small kingdoms were established in other islands to fight against Portuguese. Each kingdom introduced local language as a way of communication and unity.
* 1506: Leonardo da Vinci completes the ''Mona Lisa''.
* 1506: King Afonso I of Kongo wins the battle of Mbanza Kongo, resulting in Catholicism becoming Kingdom of Kongo, Kongo's state religion.
* 1506: At least two thousand Marrano, converted Jews are massacred in a Lisbon riot, Portugal.
* 1506: Christopher Columbus dies in Valladolid, Spain.
* 1506: Poland is invaded by Tatar invasions, Tatars from the Crimean Khanate.
* 1507: The first recorded epidemic of smallpox in the New World on the island of Hispaniola. It devastates the native Taíno population.
* 1507: Afonso de Albuquerque conquered Capture of Ormuz (1507), Hormuz and Muscat, Oman, Muscat, among other bases in the Persian Gulf, taking control of the region at the entrance of the Persian Gulf, Gulf.
* 1508: The Christianity and Islam, Christian-Islamic power struggle in Europe and West Asia spills over into the Indian Ocean as Battle of Chaul during the Portuguese-Mamluk War
* 1508–1512: Michelangelo paints the Sistine Chapel ceiling.
* 1509: The defeat of joint fleet of the Mahmud Begada, Sultan of Gujarat, the Burji dynasty, Mamlûk Burji Sultanate of Egypt, and the Saamoothiri, Zamorin of Kozhikode, Calicut with support of the Republic of Venice and the Ottoman Empire in Battle of Diu (1509), Battle of Diu marks the beginning of Portuguese people, Portuguese dominance of the Spice trade and the Indian Ocean.
* 1509: The Portuguese king sends Diogo Lopes de Sequeira to find Malacca, the eastern terminus of Asian trade. After initially receiving Sequeira, Mahmud Shah (Sultan of Malacca), Sultan Mahmud Shah captures and/or kills several of his men and attempts an assault on the four Portuguese ships, which escape.Ricklefs (1991), p.23 The Javanese fleet is also destroyed in Malacca.
* 1509: Krishnadevaraya ascends the throne of Vijayanagara Empire.
* 1509–1510: The 'great plague (disease), plague' in various parts of Tudor England.
* 1510: Afonso de Albuquerque of Portugal Portuguese conquest of Goa, conquers Goa in India.
* 1511: Afonso de Albuquerque of Portugal Capture of Malacca (1511), conquers Portuguese Malacca, Malacca, the capital of the Sultanate of Malacca in present-day Malaysia.
* 1512: Nicolaus Copernicus, Copernicus writes ''Commentariolus'', and proclaims the sun the center of the solar system.
* 1512: The southern part (historical core) of the Kingdom of Navarre is invaded by Spain, Castile and Aragon.
* 1512: Qutb Shahi dynasty, founded by Quli Qutb Mulk, rules Golconda Fort, Golconda Sultanate until 1687.
* 1512: The first Portuguese exploratory expedition was sent eastward from Malacca (in present-day Malaysia) to search for the 'Maluku Islands, Spice Islands' (Maluku Islands, Maluku) led by Francisco Serrão. Serrão is shipwrecked but struggles on to Hitu (northern Ambon Island, Ambon) and wins the favour of the local rulers.Ricklefs (1991), page 24
* 1513: Machiavelli writes ''The Prince'', a treatise about political philosophy
* 1513: The Portuguese sailor, mariner Jorge Álvares lands at Macau, China, during the Ming Dynasty.
* 1513: Henry VIII of England, Henry VIII defeats the French at the Battle of Guinegate (1513), Battle of the Spurs.
* 1513: The Battle of Flodden Field in which invading Scottish people, Scots are defeated by Henry VIII of England, Henry VIII's forces.
* 1513: Sultan Selim I ("The Grim") orders the massacre of Shia Muslims in Anatolia (present-day Turkey).
* 1513: Vasco Núñez de Balboa, in service of Spain arrives at the Pacific Ocean (which he called Mar del Sur) across the Isthmus of Panama. He was the first European to do so.
* 1514: The Battle of Orsha halts Grand Duchy of Moscow, Muscovy's expansion into Eastern Europe.
* 1514: György Dózsa, Dózsa rebellion (peasant revolt) in Kingdom of Hungary, Hungary.
* 1514: The Battle of Chaldiran, the Ottoman Empire gains decisive victory against Safavid dynasty.
* 1515: The Ottoman Empire wrests Eastern Anatolia from the Safavids after the Battle of Chaldiran.
* 1515: The Ottoman Empire, Ottomans conquers the last beyliks of Anatolia, the Beylik of Dulkadir, Dulkadirs and the Ramadanid Emirate, Ramadanids.
* 1516–1517: The Ottoman Empire, Ottomans defeat the Mamluk Sultanate (Cairo), Mamluks and gain control of Egypt, Arabian Peninsula, Arabia, and the Levant.
* 1517: The Sweating sickness epidemic in Tudor England.
* 1517: The Reformation begins when Martin Luther posts his Ninety-five Theses in Saxony.
* 1518: The Treaty of London (1518), Treaty of London was a non-aggression pact between the major European nations. The signatories were Burgundy, France, England, the Holy Roman Empire, the Netherlands, the Papal States and Spain, all of whom agreed not to attack one another and to come to the aid of any that were under attack.
* 1518: Mir Chakar Khan Rind leaves Balochistan (region), Baluchistan and settles in Punjab region, Punjab.
* 1518: Leo Africanus, also known as al-Hasan ibn Muhammad al-Wazzan al-Fasi, an Andalusian Berber diplomat who is best known for his book ''Description of Africa (1550 book), Descrittione dell’Africa'' (Description of Africa), is captured by Spanish pirates; he is taken to Rome and presented to Pope Leo X.
* 1518: The dancing plague of 1518 begins in Strasbourg, lasting for about one month.
* 1519: Leonardo da Vinci dies of natural causes on May 2.
*1519: Wang Yangming, the Chinese philosopher and governor of Jiangxi province, describes his intent to use the firepower of the ''fo-lang-ji'', a breech-loading Portuguese culverin, in order to suppress the rebellion of Prince Zhu Chenhao.
* 1519: Barbary pirates led by Hayreddin Barbarossa, a Turk appointed to ruling position in Algiers by the Ottoman Empire, raid Provence and Toulon in southern France.
* 1519: Charles I of Archduke of Austria, Austria, Spain, and the Low Countries becomes Emperor of Holy Roman Empire as Charles V, Holy Roman Emperor (ruled until 1556).
* 1519–1522: Spanish expedition commanded by Ferdinand Magellan, Magellan and Juan Sebastián Elcano, Elcano are the first to Circumnavigate the Earth.
* 1519–1521: Hernán Cortés leads the Spanish conquest of Mexico.
* 1520–1566: The reign of Suleiman the Magnificent marks the zenith of the Ottoman Empire.
* 1520: The first European diplomatic mission to Ethiopia, sent by the Portugal, Portuguese, arrives at Massawa 9 April, and reaches the imperial encampment of Emperor Dawit II in Shewa 9 October.
* 1520: Vijayanagara Empire forces under Krishnadevaraya defeat the Adil Shahi dynasty, Adil Shahi under at the Battle of Raichur
* 1520: Sultan Ali Mughayat Syah, Ali Mughayat Shah of Aceh begins an expansionist campaign capturing Daya on the west Sumatran coast (in present-day Indonesia), and the pepper and gold producing lands on the east coast.
* 1520: The Portugal, Portuguese established a trading post in the village of Lamakera on the eastern side of Solor (in present-day Indonesia) as a transit harbour between Maluku Islands, Maluku and Malacca.
* 1521: Belgrade (in present-day Serbia) is Siege of Belgrade (1521), captured by the Ottoman Empire.
* 1521: After building fortifications at Tuen Mun, the Portuguese attempt to invade Ming Dynasty China, but are expelled by Chinese naval forces.
* 1521: Philippines encountered by Ferdinand Magellan. He was later killed in the Battle of Mactan in central Philippines in the same year.
* 1521: Jiajing Emperor ascended the throne of Ming Dynasty, China.
* 1521: November, Ferdinand Magellan's expedition reaches Maluku (province), Maluku (in present-day Indonesia) and after trade with Ternate returns to Europe with a load of cloves.
* 1521: Pati Unus leads the invasion of Malacca (in present-day Malaysia) against the Portuguese occupation. Pati Unus was killed in this battle, and was succeeded by his brother, sultan Trenggana.
* 1522: Rhodes Siege of Rhodes (1522), falls to the Ottomans of Suleiman the Magnificent.
* 1522: The Portuguese ally themselves with the rulers of Sultanate of Ternate, Ternate (in present-day Indonesia) and begin construction of a fort.
* 1522: August, Luso-Sundanese Treaty signed between Portugal and Sunda Kingdom granted Portuguese permit to build fortress in Sunda Kelapa.
* 1523: Sweden Foundation of Modern Sweden, gains independence from the Kalmar Union.
* 1523: The Cacao bean is introduced to Spain by Hernán Cortés
* 1524–1525: German Peasants' War in the Holy Roman Empire.
* 1524: Giovanni da Verrazzano is the first European to explore the Atlantic Ocean, Atlantic coast of North America between South Carolina and Newfoundland (island), Newfoundland.
* 1524: Ismail I, the founder of Safavid dynasty, dies and Tahmasp I becomes king.
* 1525: Timurid Empire forces under Babur defeat the Lodi dynasty at the First Battle of Panipat, end of the Delhi Sultanate.
* 1525: Holy Roman Empire, German and Spanish Empire, Spanish forces defeat France at the Battle of Pavia, Francis I of France is captured.
* 1526: The Ottomans defeat the Kingdom of Hungary at the Battle of Mohács.
* 1526: Mughal Empire, founded by Babur, dominates India until 1857.
* 1527: Sack of Rome (1527), Sack of Rome with Pope Clement VII escaping and the Swiss Guards defending the Vatican City, Vatican being killed. The sack of the city of Rome considered the end of the Italian Renaissance.
* 1527: Protestant Reformation begins in Sweden.
* 1527: The last ruler of Majapahit falls from power. This state (located in present-day Indonesia) was finally extinguished at the hands of the Demak Sultanate, Demak. A large number of courtiers, artisans, priests, and members of the royalty moved east to the island of Bali; however, the power and the seat of government transferred to Demak under the leadership of Pangeran, later Raden Patah, Sultan Fatah.
* 1527: June 22, The Javanese Prince Fatahillah of the Sultanate of Cirebon, Cirebon Sultanate successfully defeated the Portuguese armed forces at the site of the Sunda Kelapa Harbor. The city was then renamed Jayakarta, meaning "a glorious victory." This eventful day came to be acknowledged as Jakarta's Founding Anniversary.
* 1527: Mughal Empire forces defeat the Rajput led by Rana Sanga of Mewar at the Battle of Khanwa
* 1529: The Austrians defeat the Ottoman Empire at the Siege of Vienna (1529), siege of Vienna.
* 1529: Treaty of Zaragoza (1529), Treaty of Zaragoza defined the antimeridian of Treaty of Tordesillas, Tordesillas attributing the Moluccas to Portugal and Philippines to Spain.
* 1529: Imam Ahmad Gragn defeats the Ethiopian Emperor Dawit II of Ethiopia, Dawit II in the Battle of Shimbra Kure, the opening clash of the Ethiopian–Adal War.
* 1531–1532: The History of the Church of England, Church of England breaks away from the Catholic Church and recognizes Henry VIII of England, King Henry VIII as the head of the Church.
* 1531: The Inca Civil War is fought between the two brothers, Atahualpa and Huáscar.
* 1532: Francisco Pizarro leads the Spanish conquest of the Inca Empire.
* 1532: Foundation of São Vicente, São Paulo, São Vicente, the first permanent Portuguese settlement in the Americas.
* 1533: Anne Boleyn becomes Queen of England.
* 1533: Elizabeth I of England, Elizabeth Tudor is born.
* 1534: Jacques Cartier claims Canada for France.
* 1534: The Ottomans Capture of Baghdad (1534), capture Baghdad from the Safavid Iran, Safavids.
* 1534: Affair of the Placards, where King Francis I of France, Francis I becomes more active in repression of French Protestants.
* 1535: The Münster Rebellion, an attempt of radical, Millennialism, millennialist, Anabaptists to establish a theocracy, ends in bloodshed.
* 1535: The Portuguese in Ternate depose Sultan Tabariji of Ternate, Tabariji (or Tabarija) and send him to Portuguese Goa where he converts to Christianity and bequeaths his Portuguese godfather Jordao de Freitas the island of Ambon Island, Ambon.Ricklefs (1991), page 25 Hairun becomes the next sultan.
* 1536: Katherine of Aragon dies in Kimbolton Castle, in England.
* 1536: In England, Anne Boleyn is beheaded for adultery and treason.
* 1536: Establishment of the Portuguese Inquisition, Inquisition in Portugal.
* 1536: Foundation of Buenos Aires (in present-day Argentina) by Pedro de Mendoza.
* 1537: The Portuguese Empire, Portuguese establish Recife in Pernambuco, north-east of Brazil.
* 1537: William Tyndale's partial translation of the Bible into English is published, which would eventually be incorporated into the King James Bible.
* 1538: Gonzalo Jiménez de Quesada founds Bogotá.
* 1538: Spanish Empire, Spanish–Republic of Venice, Venetian fleet is defeated by the Ottoman Turks at the Battle of Preveza.
* 1539: Hernando de Soto (explorer), Hernando de Soto explores inland North America.
*1540: The Society of Jesus, or the Jesuits, is founded by Ignatius of Loyola and six companions with the approval of Pope Paul III.
*1540: Sher Shah Suri founds the Sur Empire, Suri dynasty in South Asia, an ethnic Pashtuns, Pashtun (Pathan) of the house of Sur Dynasty, Sur, who supplanted the Mughal dynasty as rulers of North India during the reign of the relatively ineffectual second Mughal emperor Humayun. Sher Shah Suri decisively defeats Humayun in the Battle of Bilgram (May 17, 1540).
*1541: Pedro de Valdivia founds Santiago, Chile, Santiago de Chile.
*1541: An Algerian military campaign by Charles V, Holy Roman Emperor, Charles V of Spain (Habsburg) is unsuccessful.
*1541: Amazon River is encountered and explored by Francisco de Orellana.
*1541: Siege of Buda (1541), Capture of Buda and the absorption of the major part of Kingdom of Hungary, Hungary by the Ottoman Empire.
*1541: Sahib I Giray of Crimean Khanate, Crimea invades Grand Duchy of Moscow, Russia.
*1542: War resumes between Francis I of France and Emperor Charles V. This time Henry VIII of England, Henry VIII is allied with the Emperor, while James V of Scotland and Sultan Suleiman the Magnificent, Suleiman I are allied with the French people, French.
*1542: Akbar The Great is born in the Rajput Umarkot Fort
*1542: Spanish explorer Ruy López de Villalobos named the island of Samar and Leyte ''Philippines, Las Islas Filipinas'' honoring Philip II of Spain and became the official name of the archipelago.
*1543: Ethiopian/Portugal, Portuguese troops decisively defeat the Adal-Ottoman Muslim army led by Imam Ahmad ibn Ibrahim al-Ghazi, Ahmad Gragn at the Battle of Wayna Daga; Imam Ahmad ibn Ibrihim al-Ghazi, Ahmad Gragn is killed at this battle.
* 1543: Nicolaus Copernicus, Copernicus publishes his theory that the Earth and the other planets revolve around the Sun
*1543: The Nanban trade period begins after Portuguese traders make contact with Japan.
*1544: The France, French defeat an Holy Roman Empire, Imperial–Spanish Empire, Spanish army at the Battle of Ceresole.
*1544: Battle of the Shirts in Scottish clan, Scotland. The Clan Fraser, Frasers and Macdonalds of Clan Ranald fight over a disputed chiefship; reportedly, 5 Frasers and 8 Macdonalds survive.
*1545: Songhai Empire, Songhai forces sack the Mali Empire, Malian capital of Niani, Mali, Niani
*1545: The Council of Trent meets for the first time in Trent (in northern Italy).
*1546: Michelangelo Buonarroti is made chief architect of St. Peter's Basilica.
*1546: Francis Xavier works among the peoples of Ambon, Ternate and Morotai (Moro) laying the foundations for a permanent mission. (to 1547)
*1547: Henry VIII of England, Henry VIII dies in the Palace of Whitehall on 28 January at the age of 55.
*1547: Francis I of France, Francis I dies in the Château de Rambouillet on 31 March at the age of 52.
*1547: Edward VI of England, Edward VI becomes King of England and Ireland on 28 January and is crowned on 20 February at the age of 9.
*1547: Emperor Charles V, Holy Roman Emperor, Charles V decisively dismantles the Schmalkaldic League at the Battle of Mühlberg.
*1547: Grand Duchy of Moscow, Grand Prince Ivan the Terrible is crowned tsar of (All) Russia, thenceforth becoming the Tsar of Russia#Tsars of Russia, first Russian tsar.
*1548: Battle of Uedahara: Firearms are used for the first time on the battlefield in Japan, and Takeda Shingen is defeated by Murakami Yoshikiyo.
* 1548: Askia Daoud, who reigned from 1548 to 1583, establishes public libraries in Timbuktu (in present-day Mali).
*1548: The Ming Dynasty government of China issues a decree banning all foreign trade and closes down all seaports along the coast; these Hai jin laws came during the Wokou wars with Japanese pirates.
*1549: Tomé de Sousa establishes Salvador, Bahia, Salvador in Bahia, north-east of Brazil.
*1549: Arya Penangsang with the support of his teacher, Sunan Kudus, avenges the death of Raden Kikin by sending an envoy named Rangkud to kill Sunan Prawoto by Keris Kyai Satan Kober (in present-day Indonesia).
* 1550: The architect Mimar Sinan builds the Süleymaniye Mosque in Istanbul.
* 1550: Mongols led by Altan Khan invade Ming Dynasty, China and besiege Beijing.
* 1550–1551: Valladolid debate concerning the human rights of the Indigenous people of the Americas.
* 1551: Fifth outbreak of sweating sickness in England. John Caius of Shrewsbury writes the first full contemporary account of the symptoms of the disease.
* 1551: North African Barbary pirates, pirates enslave the entire population of the Maltese island Gozo, between 5,000 and 6,000, sending them to Libya.
* 1552: Russia conquers the Khanate of Kazan in central Asia.
* 1552: Jesuit China Mission, Francis Xavier dies.
* 1553: Mary I of England, Mary Tudor becomes the first queen regnant of England and restores the Church of England under Papal authority.
* 1553: The Portuguese people, Portuguese found a settlement at History of Macau, Macau.
* 1554: Missionary, Missionaries José de Anchieta and Manuel da Nóbrega establishes São Paulo, southeast Brazil.
* 1554: Elizabeth I of England, Princess Elizabeth is imprisoned in the Tower of London upon the orders of Mary I of England, Mary I for suspicion of being involved in the Wyatt's rebellion, Wyatt rebellion.
* 1555: The Muscovy Company is the first major English Joint stock company, joint stock trading company.
* 1556: Publication in Venice of Delle Navigiationi et Viaggi (terzo volume) by Giovanni Battista Ramusio, secretary of Council of Ten, with plan ''La Terra de Hochelaga'', an illustration of the Hochelaga (village), Hochelaga.
* 1556: The Shaanxi earthquake in China is history's deadliest known earthquake during the Ming dynasty.
* 1556: Georgius Agricola, the "Father of Mineralogy", publishes his ''De re metallica''.
* 1556: Akbar defeats Hemu at the Second battle of Panipat.
* 1556: Russia conquers the Astrakhan Khanate.
* 1556–1605: During his reign, Akbar expands the Mughal Empire in a series of conquests (in the Indian subcontinent).
* 1556: Mir Chakar Khan Rind captures Delhi with Humayun.
* 1556: Pomponio Algerio, radical theologian, is executed by boiling in oil as part of the Roman inquisition.
* 1557: Habsburg Spain declares bankruptcy. Philip II of Spain had to declare four National bankruptcy, state bankruptcies in 1557, 1560, 1575 and 1596.
* 1557: The Portuguese people, Portuguese settle in Macau (on the western side of the Pearl River Delta across from present-day Hong Kong).
* 1557: The Ottoman Empire, Ottomans capture Massawa, all but isolating Ethiopia from the rest of the world.
* 1558: Elizabeth I of England, Elizabeth Tudor becomes Queen Elizabeth I at age 25.
* 1558–1603: The Elizabethan era is considered the height of the English Renaissance.
* 1558–1583: Livonian War between Poland, Grand Principality of Lithuania, Sweden, Denmark and Russia.
* 1558: After 200 years, the Kingdom of England loses Calais to France.
* 1559: With the Peace of Cateau Cambrésis, the Italian Wars conclude.
* 1559: Sultan Hairun of Ternate (in present-day Indonesia) protests the Portuguese's Christianity, Christianisation activities in his lands. Hostilities between Sultanate of Ternate, Ternate and the Portuguese.
* 1560: Ottoman navy defeats the Spanish Empire, Spanish fleet at the Battle of Djerba.
* 1560: Elizabeth Bathory is born in Nyirbator, Hungary.
* 1560: By winning the Battle of Okehazama, Oda Nobunaga becomes one of the pre-eminent warlords of Japan.
* 1560: Jeanne d'Albret declares Calvinism the official religion of Kingdom of Navarre, Navarre.
* 1560: St. Lazarus' Church, Macau, Lazarus Church, Macau
* 1561: Sir Francis Bacon is born in London.
* 1561: The battles of Kawanakajima, fourth battle of Kawanakajima between the Uesugi and Takeda at Hachimanbara takes place.
* 1561: Guido de Bres draws up the Belgic Confession of Protestant faith.
* 1562: Mughal Empire, Mughal emperor Akbar reconciles the Muslim and Hindu factions by marrying into the powerful Rajput Hindu caste.
* 1562–1598: French Wars of Religion between Catholics and Huguenots.
* 1562: Massacre of Wassy and Battle of Dreux in the French Wars of Religion.
* 1562: Portuguese Dominican Order, Dominican priests build a palm-trunk fortress which Javanese people, Javanese Muslims burned down the following year. The fort was rebuilt from more durable materials and the Dominicans commenced the Christianity, Christianisation of the local population.
* 1563: Black Death, Plague outbreak claimed 80,000 people in Elizabethan era, Elizabethan Kingdom of England, England. In London alone, over 20,000 people died of the disease.
* 1564: Galileo Galilei born on February 15
* 1564: William Shakespeare baptized 26 April
* 1565: Deccan sultanates defeat the Vijayanagara Empireat the Battle of Talikota.
* 1565: Mir Chakar Khan Rind dies at aged 97.
* 1565: Estácio de Sá establishes Rio de Janeiro in Brazil.
* 1565: The Knights Hospitaller, Hospitallers, a Crusading Order, defeat the Ottoman Empire at the siege of Malta (1565).
* 1565: Miguel López de Legazpi establishes in Cebu the first Spanish settlement in the Philippines starting a period of Spanish colonization that would last over three hundred years.
* 1565: Spanish navigator Andres de Urdaneta discovers the maritime route from Asia to the Americas across the Pacific Ocean, also known as the ''tornaviaje''.
* 1565: Royal Exchange, London, Royal Exchange is founded by Thomas Gresham.
* 1566: Suleiman the Magnificent, ruler of the Ottoman Empire, dies on September 7, during the battle of Szigetvar.
* 1566–1648: Eighty Years' War between Spain and the Netherlands.
* 1566: Da le Balle Contrade d'Oriente, composed by Cipriano de Rore.
* 1567: After 45 years' reign, Jiajing Emperor died in the Forbidden City, Longqing Emperor ascended the throne of Ming Dynasty.
* 1567: Mary, Queen of Scots, is imprisoned by Elizabeth I.
* 1568: The Principality of Transylvania (1570–1711), Transylvanian Diet (assembly), Diet, under the patronage of the prince John Sigismund Zápolya, the former king of Hungary, inspired by the teachings of Ferenc Dávid, the founder of the Unitarian Church of Transylvania, promulgates the Edict of Torda, the first law of freedom of religion and of conscience in the World.
* 1568–1571: Morisco Revolt in Spain.
* 1568–1600: The Azuchi-Momoyama period in Japan.
* 1568: Hadiwijaya sent his adopted son and son in-law Senopati, Sutawijaya, who would later become the first ruler of the Mataram Sultanate, Mataram dynasty of Indonesia, to kill Arya Penangsang.
* 1569: Rising of the North in England.
* 1569: Mercator 1569 world map published by Gerardus Mercator.
* 1569: The Polish–Lithuanian Commonwealth is created with the Union of Lublin which lasts until 1795.
* 1569: Peace treaty signed by Sultan Hairun of Ternate and Governor Lopez De Mesquita of Portugal.
* 1570: Ivan the Terrible, tsar of Russia, orders the massacre of inhabitants of Novgorod.
* 1570: Pope Pius V issues ''Regnans in Excelsis'', a papal bull excommunicating all who obeyed Elizabeth I and calling on all Catholics to rebel against her.
* 1570: Sultan Hairun of Ternate (in present-day Indonesia) is killed by the Portuguese. Babullah of Ternate, Babullah becomes the next Sultan.
* 1571: Pope Pius V completes the Holy League (Mediterranean), Holy League as a united front against the Ottoman Empire, Ottoman Turks.
* 1571: The Spanish-led Holy League navy destroys the Ottoman Empire navy at the Battle of Lepanto (1571), Battle of Lepanto.
* 1571: Crimean Khanate, Crimean Tatars attack and Russo-Crimean Wars, sack Moscow, burning everything but the Moscow Kremlin, Kremlin.
* 1571: Native Americans in the United States, American Indians kill Spanish missionaries in what would later be Jamestown, Virginia.
* 1571: Spanish conquistador Miguel López de Legazpi establishes Manila, Philippines as the capital of the Spanish East Indies.
* 1572: Brielle is taken from Habsburg Spain by Protestant Watergeuzen in the Capture of Brielle, in the Eighty Years' War.
* 1572: Conquistador, Spanish conquistadores apprehend the last Inca Empire, Inca leader Tupak Amaru at Vilcabamba, Peru, and execute him in Cuzco.
* 1572: Jeanne d'Albret dies aged 43 and is succeeded by Henry IV of France, Henry of Navarre.
* 1572: Catherine de' Medici instigates the St. Bartholomew's Day massacre which takes the lives of Protestant leader Gaspard II de Coligny, Gaspard de Coligny and thousands of Huguenots. The violence spreads from Paris to other cities and the countryside.
* 1572: First edition of the epic The Lusiads of Luís Vaz de Camões, three years after the author returned from the East.
* 1572: The 9 years old Crown prince, Taizi, Zhu Yijun ascended the throne of Ming Dynasty, known as Wanli Emperor.
* 1573: After heavy losses on both sides the siege of Haarlem ends in a Spain, Spanish victory.
* 1574: in the Eighty Years' War the capital of County of Zeeland, Zeeland, Middelburg, Zeeland, Middelburg declares for the Protestants.
* 1574: After a siege of 4 months the siege of Leiden ends in a comprehensive Dutch Revolt, Dutch rebel victory.
* 1575: Oda Nobunaga finally captures Nagashima fortress.
* 1575: Following a five-year war, the Ternateans under Sultan Babullah of Ternate, Babullah defeated the Portuguese.
* 1576: Tahmasp I, Safavid shah, dies.
* 1576: The Battle of Haldighati is fought between the ruler of Mewar, Maharana Pratap and the Mughal Empire's forces under Emperor Akbar led by Raja Man Singh.
* 1576: Sack of Antwerp by badly paid Spaniards, Spanish soldiers.
* 1577–1580: Francis Drake Circumnavigation, circles the world.
* 1577: Ki Ageng Pemanahan built his palace in Pasargede or Kotagede.
* 1578: King Sebastian of Portugal is killed at the Battle of Alcazarquivir.
* 1578: The Portuguese establish a fort on Tidore but the main centre for Portuguese activities in Maluku becomes Ambon.
* 1578: 3rd Dalai Lama, Sonam Gyatso is conferred the title of Dalai Lama by Tumed Mongol ruler, Altan Khan. Recognised as the reincarnation of two previous Lamas, Sonam Gyatso becomes the third Dalai Lama in the lineage.
* 1579: The Union of Utrecht unifies the northern Netherlands, a foundation for the later Dutch Republic.
* 1579: The Union of Arras unifies the southern Netherlands, a foundation for the later states of the Spanish Netherlands, the Austrian Netherlands and Belgium.
* 1579: The British navigator Sir Francis Drake passes through Maluku and transit in Ternate on his circumnavigation of the world. The Portuguese establish a fort on Tidore but the main centre for Portuguese activities in Maluku becomes Ambon.
* 1580: Francis Drake, Drake's royal reception after his attacks on Spanish possessions influences Philip II of Spain to build up the Spanish Armada. English ships in Spanish harbours are impounded.
* 1580: Spain unifies with Portugal under Philip II of Spain, Philip II. The struggle for the throne of Portugal ends the Portuguese Empire. The Spanish and Portuguese crowns are Iberian Union, united for 60 years, i.e. until 1640.
* 1580–1587: Nagasaki comes under control of the Jesuits.
* 1581: Dutch Act of Abjuration, declaring abjuring allegiance to Philip II of Spain.
* 1581: Bayinnaung dies at the age of 65.
* 1582: Oda Nobunaga commits seppuku during the Honnō-ji Incident coup by his general, Akechi Mitsuhide.
* 1582: Pope Gregory XIII issues the Gregorian calendar. The last day of the Julian calendar was Thursday, 4 October 1582 and this was followed by the first day of the Gregorian calendar, Friday, 15 October 1582
* 1582: Yermak Timofeyevich conquers the Siberia Khanate on behalf of the Stroganovs.
* 1583: Denmark builds the world's first theme park, Dyrehavsbakken, Bakken.
* 1583: Death of Sultan Babullah of Ternate.
* 1584–1585: After the Siege of Antwerp (1584-1585), siege of Antwerp, many of its merchants flee to Amsterdam. According to Luc-Normand Tellier, "At its peak, between 1510 and 1557, Antwerp concentrated about 40% of the world trade...It is estimated that the port of Antwerp was earning the Spanish crown seven times more revenues than the Spanish colonization of the Americas, Americas."
* 1584: Gedhe Pamanahan, Ki Ageng Pemanahan died. Sultan Pajang raised Sutawijaya, son of Ki Ageng Pemanahan as the new ruler in Mataram Sultanate, Mataram, titled "Loring Ngabehi Market" (because of his home in the north of the market).
* 1585: Akbar annexes Kashmir and adds it to the History of Afghanistan#Mughals, Uzbeks, and Safavids, Kabul Subah
* 1585: Colony at Roanoke Colony, Roanoke founded in North America.
* 1585–1604: The Anglo-Spanish War (1585), Anglo-Spanish War is fought on both sides of the Atlantic.
* 1587: Mary, Queen of Scots is executed by Elizabeth I.
* 1587: The reign of Abbas I of Persia, Abbas I marks the zenith of the Safavid dynasty.
* 1587: Troops that would invade Pajang Mataram Sultanate storm ravaged the eruption of Mount Merapi. Sutawijaya and his men survived.
* 1588: Mataram into the kingdom with Sutawijaya as Sultan, titled "Senapati Ingalaga Sayidin Panatagama" means the warlord and cleric Manager Religious Life.
* 1588: England repulses the Spanish Armada.
* 1589: Spain repulses the English Armada.
* 1589: Catherine de' Medici dies at aged 69.
* 1590: Siege of Odawara (1590), Siege of Odawara: the Late Hōjō clan, Go-Hojo clan surrender to Toyotomi Hideyoshi, and Japan is unified.
* 1591: List of Crimean khans, Gazi Giray leads a huge Tatar expedition against Moscow.
* 1591: In Mali, Morocco, Moroccan forces of the Sultan Ahmad I al-Mansur Saadi, Ahmad al-Mansur led by Judar Pasha defeat the Songhai Empire at the Battle of Tondibi.
* 1592–1593: John Stow reports 10,675 Black Death, plague deaths in London, a city of approximately 200,000 people.
* 1592–1598: Korea, with the help of Ming Dynasty China, repels Hideyoshi's invasions of Korea, two Japanese invasions.
* 1593–1606: The Long War (Ottoman wars), Long War between the Habsburg monarchy and the Ottoman Empire, Ottoman Turks.
* 1594: St. Paul's College, Macau, founded by Alessandro Valignano.
* 1595: First Dutch expedition to Indonesia sets sail for the East Indies with two hundred and forty-nine men and sixty-four cannons led by Cornelis de Houtman.Ricklefs (1991), page 27
* 1596: Birth of René Descartes.
* 1596: June, de Houtman's expedition reaches Banten the main pepper port of West Java where they clash with both the Portuguese and Indonesians. It then sails east along the north coast of Java losing twelve crew to a Javanese attack at Sidayu and killing a local ruler in Madura.
* 1597: ''Romeo and Juliet'' is published.
* 1597: Cornelis de Houtman's expedition returns to the Netherlands with enough spices to make a considerable profit.
* 1598: The Edict of Nantes ends the French Wars of Religion.
* 1598: Abbas I of Persia, Abbas I moves Safavids capital from Qazvin to Isfahan in 1598.
* 1598–1613: Russia descends into anarchy during the Time of Troubles.
* 1598: The Portuguese require an armada of 90 ships to put down a Solorese uprising. (to 1599)
* 1598: More Dutch fleets leave for Indonesia and most are profitable.
* 1598: The province of Santa Fe de Nuevo México is established in Northern New Spain. The region would later become a territory of Mexico, the New Mexico Territory in the United States, and the US State of New Mexico.
* 1598: Death of Toyotomi Hideyoshi, known as the unifier of Japan.
* 1599: The Mali Empire is defeated at the Battle of Jenné.
* 1599: The van Neck expedition returns to Europe. The expedition makes a 400 per cent profit. (to 1600)
* 1599: March, Leaving Europe the previous year, a Second Dutch Expedition to Indonesia (1598-1600), fleet of eight ships under Jacob van Neck was the first Dutch fleet to reach the ‘Spice Islands’ of Maluku.
* 1600: Giordano Bruno is burned at the stake for Christian heresy, heresy in Rome.
* 1600: Battle of Sekigahara in Japan. End of the Sengoku period, Warring States period and beginning of the Edo period.
* 1600: The Portuguese win a major naval battle in the bay of Ambon.Ricklefs (1991), page 28 Later in the year, the Dutch join forces with the local Hituese in an anti-Portuguese alliance, in return for which the Dutch would have the sole right to purchase spices from Hitu.
* 1600: Elizabeth I grants a charter to the British East India Company beginning the English advance in Asia.
* 1600: Michael the Brave unifies the three Romanian principalities: Wallachia, Moldavia and Principality of Transylvania (1570–1711), Transylvania after the Battle of Șelimbăr from 1599.
File:Alberico Gentili.jpg, Alberico Gentili, Dr Alberico Gentili, the Father of international law
File:Vasili III of Russia.jpg, Vasily III, Grand Duke of Moscow by André Thévet
File:Hernán Cortés anónimo.jpg, Hernán Cortés, Hernan Cortes
File:Akbar1.jpg, Akbar, Akbar the Great
File:Philip II, King of Spain from NPG.jpg, Philip II of Spain
File:François Ier Louvre.jpg, Francis I of France, Francis I of France
File:Hans Holbein, the Younger, Around 1497-1543 - Portrait of Henry VIII of England - Google Art Project.jpg, Hans Holbein the Younger, c. 1536 – 1537, ''Henry VIII of England, Henry VIII,'' King of England and Ireland
File:Fernando Álvarez de Toledo, III Duque de Alba, por Antonio Moro.jpg, Don Fernando Álvarez de Toledo, 3rd Duke of Alba, Fernando Álvarez de Toledo
File:Ivan IV by anonim (18th c., GIM).jpg, Ivan IV the Terrible
File:1590 or later Marcus Gheeraerts, Sir Francis Drake Buckland Abbey, Devon.jpg, Francis Drake, Sir Francis Drake
File:Odanobunaga.jpg, Oda Nobunaga
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{{DEFAULTSORT:16th Century 16th century, Centuries Early Modern period 2nd millennium
The 16th century begins with the Julian calendar, Julian year 1501 (Roman numerals, MDI) and ends with either the Julian or the Gregorian calendar, Gregorian year 1600 (Roman numerals, MDC) (depending on the reckoning used; the Gregorian calendar introduced a lapse of 10 days in October 1582).
The 16th century is regarded by historians as the century which saw the rise of Western culture, Western civilization and the Gunpowder empires, Islamic gunpowder empires. The Renaissance in Italy and Europe saw the emergence of important artists, authors and scientists, and led to the foundation of important subjects which include accounting and political science. Copernicus proposed the Copernican heliocentrism, heliocentric universe, which was met with strong resistance, and Tycho Brahe refuted the theory of celestial spheres through observational measurement of the SN 1572, 1572 appearance of a Milky Way supernova. These events directly challenged the long-held notion of an immutable universe supported by Ptolemy and Aristotle, and led to major revolutions in astronomy and science. Galileo Galilei became a champion of the new sciences, invented the first thermometer and made substantial contributions in the fields of physics and astronomy, becoming a major figure in the Scientific Revolution.
Spain and Portugal colonized large parts of Central America, Central and South America, followed by France and England in Northern America and the Lesser Antilles. The Portuguese became the masters of trade between Brazil, the coasts of Africa, and their possessions in the East Indies, Indies, whereas the Spanish came to dominate the Greater Antilles, Mexico, Peru, and opened trade across the Pacific Ocean, linking the Americas with the Indies. English and French privateers began to practice persistent theft of Spanish and Portuguese treasures. This era of colonialism established mercantilism as the leading school of economic thought, where the economic system was viewed as a zero-sum game in which any gain by one party required a loss by another. The mercantilist doctrine encouraged the many intra-European wars of the period and arguably fueled European Expansionism, expansion and imperialism throughout the world until the 19th century or early 20th century.
The Reformation in central and northern Europe gave a major blow to the authority of the Pope, papacy and the Catholic Church. In Kingdom of England, England, the British-Italian Alberico Gentili wrote the first book on public international law and divided secularism from canon law and Catholic theology. European politics became dominated by religious conflicts, with the groundwork for the epochal Thirty Years' War being laid towards the end of the century.
In the Middle East, the Ottoman Empire continued to expand, with the Sultan taking the title of Caliph, while dealing with a resurgent Persia. Iran and Iraq were caught by a major popularity of the Shia Islam, Shia sect of Islam under the rule of the Safavid dynasty of warrior-mystics, providing grounds for a Persia independent of the majority-Sunni Islam, Sunni Muslim world.
In the Indian subcontinent, following the defeat of the Delhi Sultanate and Vijayanagara Empire, new powers emerged, the Sur Empire founded by Sher Shah Suri, Deccan sultanates, and the Mughal Empire by Emperor Babur, a direct descendant of Timur and Genghis Khan. His successors Humayun and Akbar, enlarged the empire to include most of South Asia. The empire developed a strong and stable economy in the world, leading to commercial expansion and greater patronage of culture, which significantly influenced the course of History of India, Indian history.
Japan suffered a severe civil war at this time, known as the Sengoku period, and emerged from it as a unified nation. China was ruled by the Ming dynasty and came into conflict with Japan and Japanese piracy over the control of Korea.
Significant events
1501–1509
* 1501: Michelangelo returns to his native Florence to begin work on the statue ''David (Michelangelo), David''.
* 1501: Safavids, Safavid dynasty reunifies Iran and rules over it until 1736. Safavids adopt a Shia Islam, Shia branch of Islam.
* 1501: First Battle of Cannanore between the 3rd Portuguese India Armada (Nova, 1501), Third Portuguese Armada and Kingdom of Cochin under João da Nova and Zamorin of Kozhikode's navy marks the beginning of Portuguese conflicts in the Indian Ocean.
* 1502: First reported Slavery, African slaves in the New World
* 1502: The Crimean Khanate sacks Sarai (city), Sarai in the Golden Horde, ending its existence.
* 1503: Spanish Empire, Spain defeats Early Modern France, France at the Battle of Cerignola. Considered to be the first battle in history won by gunpowder small arms.
* 1503: Leonardo da Vinci begins painting the ''Mona Lisa'' and completes it three years later.
* 1503: Nostradamus is born on either December 14 or December 21.
* 1504: A period of drought, with famine in all of Spain.
* 1504: Death of Isabella I of Castile; Joanna of Castille, Joanna of Castile becomes the Queen.
* 1504: Foundation of the Sultanate of Sennar by Amara Dunqas, in what is modern Sudan
* 1505: Zhengde Emperor ascends the throne of Ming Dynasty.
* 1505: Martin Luther enters St. Augustine's Monastery (Erfurt), St. Augustine's Monastery at Erfurt, Germany, on 17 July and begins his journey to instigating the Reformation.
* 1505: Trenggana, Sultan Trenggono builds the first Muslim kingdom in Java, called Demak Sultanate, Demak, in Indonesia. Many other small kingdoms were established in other islands to fight against Portuguese. Each kingdom introduced local language as a way of communication and unity.
* 1506: Leonardo da Vinci completes the ''Mona Lisa''.
* 1506: King Afonso I of Kongo wins the battle of Mbanza Kongo, resulting in Catholicism becoming Kingdom of Kongo, Kongo's state religion.
* 1506: At least two thousand Marrano, converted Jews are massacred in a Lisbon riot, Portugal.
* 1506: Christopher Columbus dies in Valladolid, Spain.
* 1506: Poland is invaded by Tatar invasions, Tatars from the Crimean Khanate.
* 1507: The first recorded epidemic of smallpox in the New World on the island of Hispaniola. It devastates the native Taíno population.
* 1507: Afonso de Albuquerque conquered Capture of Ormuz (1507), Hormuz and Muscat, Oman, Muscat, among other bases in the Persian Gulf, taking control of the region at the entrance of the Persian Gulf, Gulf.
* 1508: The Christianity and Islam, Christian-Islamic power struggle in Europe and West Asia spills over into the Indian Ocean as Battle of Chaul during the Portuguese-Mamluk War
* 1508–1512: Michelangelo paints the Sistine Chapel ceiling.
* 1509: The defeat of joint fleet of the Mahmud Begada, Sultan of Gujarat, the Burji dynasty, Mamlûk Burji Sultanate of Egypt, and the Saamoothiri, Zamorin of Kozhikode, Calicut with support of the Republic of Venice and the Ottoman Empire in Battle of Diu (1509), Battle of Diu marks the beginning of Portuguese people, Portuguese dominance of the Spice trade and the Indian Ocean.
* 1509: The Portuguese king sends Diogo Lopes de Sequeira to find Malacca, the eastern terminus of Asian trade. After initially receiving Sequeira, Mahmud Shah (Sultan of Malacca), Sultan Mahmud Shah captures and/or kills several of his men and attempts an assault on the four Portuguese ships, which escape.Ricklefs (1991), p.23 The Javanese fleet is also destroyed in Malacca.
* 1509: Krishnadevaraya ascends the throne of Vijayanagara Empire.
1510s
* 1509–1510: The 'great plague (disease), plague' in various parts of Tudor England.
* 1510: Afonso de Albuquerque of Portugal Portuguese conquest of Goa, conquers Goa in India.
* 1511: Afonso de Albuquerque of Portugal Capture of Malacca (1511), conquers Portuguese Malacca, Malacca, the capital of the Sultanate of Malacca in present-day Malaysia.
* 1512: Nicolaus Copernicus, Copernicus writes ''Commentariolus'', and proclaims the sun the center of the solar system.
* 1512: The southern part (historical core) of the Kingdom of Navarre is invaded by Spain, Castile and Aragon.
* 1512: Qutb Shahi dynasty, founded by Quli Qutb Mulk, rules Golconda Fort, Golconda Sultanate until 1687.
* 1512: The first Portuguese exploratory expedition was sent eastward from Malacca (in present-day Malaysia) to search for the 'Maluku Islands, Spice Islands' (Maluku Islands, Maluku) led by Francisco Serrão. Serrão is shipwrecked but struggles on to Hitu (northern Ambon Island, Ambon) and wins the favour of the local rulers.Ricklefs (1991), page 24
* 1513: Machiavelli writes ''The Prince'', a treatise about political philosophy
* 1513: The Portuguese sailor, mariner Jorge Álvares lands at Macau, China, during the Ming Dynasty.
* 1513: Henry VIII of England, Henry VIII defeats the French at the Battle of Guinegate (1513), Battle of the Spurs.
* 1513: The Battle of Flodden Field in which invading Scottish people, Scots are defeated by Henry VIII of England, Henry VIII's forces.
* 1513: Sultan Selim I ("The Grim") orders the massacre of Shia Muslims in Anatolia (present-day Turkey).
* 1513: Vasco Núñez de Balboa, in service of Spain arrives at the Pacific Ocean (which he called Mar del Sur) across the Isthmus of Panama. He was the first European to do so.
* 1514: The Battle of Orsha halts Grand Duchy of Moscow, Muscovy's expansion into Eastern Europe.
* 1514: György Dózsa, Dózsa rebellion (peasant revolt) in Kingdom of Hungary, Hungary.
* 1514: The Battle of Chaldiran, the Ottoman Empire gains decisive victory against Safavid dynasty.
* 1515: The Ottoman Empire wrests Eastern Anatolia from the Safavids after the Battle of Chaldiran.
* 1515: The Ottoman Empire, Ottomans conquers the last beyliks of Anatolia, the Beylik of Dulkadir, Dulkadirs and the Ramadanid Emirate, Ramadanids.
* 1516–1517: The Ottoman Empire, Ottomans defeat the Mamluk Sultanate (Cairo), Mamluks and gain control of Egypt, Arabian Peninsula, Arabia, and the Levant.
* 1517: The Sweating sickness epidemic in Tudor England.
* 1517: The Reformation begins when Martin Luther posts his Ninety-five Theses in Saxony.
* 1518: The Treaty of London (1518), Treaty of London was a non-aggression pact between the major European nations. The signatories were Burgundy, France, England, the Holy Roman Empire, the Netherlands, the Papal States and Spain, all of whom agreed not to attack one another and to come to the aid of any that were under attack.
* 1518: Mir Chakar Khan Rind leaves Balochistan (region), Baluchistan and settles in Punjab region, Punjab.
* 1518: Leo Africanus, also known as al-Hasan ibn Muhammad al-Wazzan al-Fasi, an Andalusian Berber diplomat who is best known for his book ''Description of Africa (1550 book), Descrittione dell’Africa'' (Description of Africa), is captured by Spanish pirates; he is taken to Rome and presented to Pope Leo X.
* 1518: The dancing plague of 1518 begins in Strasbourg, lasting for about one month.
* 1519: Leonardo da Vinci dies of natural causes on May 2.
*1519: Wang Yangming, the Chinese philosopher and governor of Jiangxi province, describes his intent to use the firepower of the ''fo-lang-ji'', a breech-loading Portuguese culverin, in order to suppress the rebellion of Prince Zhu Chenhao.
* 1519: Barbary pirates led by Hayreddin Barbarossa, a Turk appointed to ruling position in Algiers by the Ottoman Empire, raid Provence and Toulon in southern France.
* 1519: Charles I of Archduke of Austria, Austria, Spain, and the Low Countries becomes Emperor of Holy Roman Empire as Charles V, Holy Roman Emperor (ruled until 1556).
* 1519–1522: Spanish expedition commanded by Ferdinand Magellan, Magellan and Juan Sebastián Elcano, Elcano are the first to Circumnavigate the Earth.
* 1519–1521: Hernán Cortés leads the Spanish conquest of Mexico.
1520s
* 1520–1566: The reign of Suleiman the Magnificent marks the zenith of the Ottoman Empire.
* 1520: The first European diplomatic mission to Ethiopia, sent by the Portugal, Portuguese, arrives at Massawa 9 April, and reaches the imperial encampment of Emperor Dawit II in Shewa 9 October.
* 1520: Vijayanagara Empire forces under Krishnadevaraya defeat the Adil Shahi dynasty, Adil Shahi under at the Battle of Raichur
* 1520: Sultan Ali Mughayat Syah, Ali Mughayat Shah of Aceh begins an expansionist campaign capturing Daya on the west Sumatran coast (in present-day Indonesia), and the pepper and gold producing lands on the east coast.
* 1520: The Portugal, Portuguese established a trading post in the village of Lamakera on the eastern side of Solor (in present-day Indonesia) as a transit harbour between Maluku Islands, Maluku and Malacca.
* 1521: Belgrade (in present-day Serbia) is Siege of Belgrade (1521), captured by the Ottoman Empire.
* 1521: After building fortifications at Tuen Mun, the Portuguese attempt to invade Ming Dynasty China, but are expelled by Chinese naval forces.
* 1521: Philippines encountered by Ferdinand Magellan. He was later killed in the Battle of Mactan in central Philippines in the same year.
* 1521: Jiajing Emperor ascended the throne of Ming Dynasty, China.
* 1521: November, Ferdinand Magellan's expedition reaches Maluku (province), Maluku (in present-day Indonesia) and after trade with Ternate returns to Europe with a load of cloves.
* 1521: Pati Unus leads the invasion of Malacca (in present-day Malaysia) against the Portuguese occupation. Pati Unus was killed in this battle, and was succeeded by his brother, sultan Trenggana.
* 1522: Rhodes Siege of Rhodes (1522), falls to the Ottomans of Suleiman the Magnificent.
* 1522: The Portuguese ally themselves with the rulers of Sultanate of Ternate, Ternate (in present-day Indonesia) and begin construction of a fort.
* 1522: August, Luso-Sundanese Treaty signed between Portugal and Sunda Kingdom granted Portuguese permit to build fortress in Sunda Kelapa.
* 1523: Sweden Foundation of Modern Sweden, gains independence from the Kalmar Union.
* 1523: The Cacao bean is introduced to Spain by Hernán Cortés
* 1524–1525: German Peasants' War in the Holy Roman Empire.
* 1524: Giovanni da Verrazzano is the first European to explore the Atlantic Ocean, Atlantic coast of North America between South Carolina and Newfoundland (island), Newfoundland.
* 1524: Ismail I, the founder of Safavid dynasty, dies and Tahmasp I becomes king.
* 1525: Timurid Empire forces under Babur defeat the Lodi dynasty at the First Battle of Panipat, end of the Delhi Sultanate.
* 1525: Holy Roman Empire, German and Spanish Empire, Spanish forces defeat France at the Battle of Pavia, Francis I of France is captured.
* 1526: The Ottomans defeat the Kingdom of Hungary at the Battle of Mohács.
* 1526: Mughal Empire, founded by Babur, dominates India until 1857.
* 1527: Sack of Rome (1527), Sack of Rome with Pope Clement VII escaping and the Swiss Guards defending the Vatican City, Vatican being killed. The sack of the city of Rome considered the end of the Italian Renaissance.
* 1527: Protestant Reformation begins in Sweden.
* 1527: The last ruler of Majapahit falls from power. This state (located in present-day Indonesia) was finally extinguished at the hands of the Demak Sultanate, Demak. A large number of courtiers, artisans, priests, and members of the royalty moved east to the island of Bali; however, the power and the seat of government transferred to Demak under the leadership of Pangeran, later Raden Patah, Sultan Fatah.
* 1527: June 22, The Javanese Prince Fatahillah of the Sultanate of Cirebon, Cirebon Sultanate successfully defeated the Portuguese armed forces at the site of the Sunda Kelapa Harbor. The city was then renamed Jayakarta, meaning "a glorious victory." This eventful day came to be acknowledged as Jakarta's Founding Anniversary.
* 1527: Mughal Empire forces defeat the Rajput led by Rana Sanga of Mewar at the Battle of Khanwa
* 1529: The Austrians defeat the Ottoman Empire at the Siege of Vienna (1529), siege of Vienna.
* 1529: Treaty of Zaragoza (1529), Treaty of Zaragoza defined the antimeridian of Treaty of Tordesillas, Tordesillas attributing the Moluccas to Portugal and Philippines to Spain.
* 1529: Imam Ahmad Gragn defeats the Ethiopian Emperor Dawit II of Ethiopia, Dawit II in the Battle of Shimbra Kure, the opening clash of the Ethiopian–Adal War.
1530s
* 1531–1532: The History of the Church of England, Church of England breaks away from the Catholic Church and recognizes Henry VIII of England, King Henry VIII as the head of the Church.
* 1531: The Inca Civil War is fought between the two brothers, Atahualpa and Huáscar.
* 1532: Francisco Pizarro leads the Spanish conquest of the Inca Empire.
* 1532: Foundation of São Vicente, São Paulo, São Vicente, the first permanent Portuguese settlement in the Americas.
* 1533: Anne Boleyn becomes Queen of England.
* 1533: Elizabeth I of England, Elizabeth Tudor is born.
* 1534: Jacques Cartier claims Canada for France.
* 1534: The Ottomans Capture of Baghdad (1534), capture Baghdad from the Safavid Iran, Safavids.
* 1534: Affair of the Placards, where King Francis I of France, Francis I becomes more active in repression of French Protestants.
* 1535: The Münster Rebellion, an attempt of radical, Millennialism, millennialist, Anabaptists to establish a theocracy, ends in bloodshed.
* 1535: The Portuguese in Ternate depose Sultan Tabariji of Ternate, Tabariji (or Tabarija) and send him to Portuguese Goa where he converts to Christianity and bequeaths his Portuguese godfather Jordao de Freitas the island of Ambon Island, Ambon.Ricklefs (1991), page 25 Hairun becomes the next sultan.
* 1536: Katherine of Aragon dies in Kimbolton Castle, in England.
* 1536: In England, Anne Boleyn is beheaded for adultery and treason.
* 1536: Establishment of the Portuguese Inquisition, Inquisition in Portugal.
* 1536: Foundation of Buenos Aires (in present-day Argentina) by Pedro de Mendoza.
* 1537: The Portuguese Empire, Portuguese establish Recife in Pernambuco, north-east of Brazil.
* 1537: William Tyndale's partial translation of the Bible into English is published, which would eventually be incorporated into the King James Bible.
* 1538: Gonzalo Jiménez de Quesada founds Bogotá.
* 1538: Spanish Empire, Spanish–Republic of Venice, Venetian fleet is defeated by the Ottoman Turks at the Battle of Preveza.
* 1539: Hernando de Soto (explorer), Hernando de Soto explores inland North America.
1540s
*1540: The Society of Jesus, or the Jesuits, is founded by Ignatius of Loyola and six companions with the approval of Pope Paul III.
*1540: Sher Shah Suri founds the Sur Empire, Suri dynasty in South Asia, an ethnic Pashtuns, Pashtun (Pathan) of the house of Sur Dynasty, Sur, who supplanted the Mughal dynasty as rulers of North India during the reign of the relatively ineffectual second Mughal emperor Humayun. Sher Shah Suri decisively defeats Humayun in the Battle of Bilgram (May 17, 1540).
*1541: Pedro de Valdivia founds Santiago, Chile, Santiago de Chile.
*1541: An Algerian military campaign by Charles V, Holy Roman Emperor, Charles V of Spain (Habsburg) is unsuccessful.
*1541: Amazon River is encountered and explored by Francisco de Orellana.
*1541: Siege of Buda (1541), Capture of Buda and the absorption of the major part of Kingdom of Hungary, Hungary by the Ottoman Empire.
*1541: Sahib I Giray of Crimean Khanate, Crimea invades Grand Duchy of Moscow, Russia.
*1542: War resumes between Francis I of France and Emperor Charles V. This time Henry VIII of England, Henry VIII is allied with the Emperor, while James V of Scotland and Sultan Suleiman the Magnificent, Suleiman I are allied with the French people, French.
*1542: Akbar The Great is born in the Rajput Umarkot Fort
*1542: Spanish explorer Ruy López de Villalobos named the island of Samar and Leyte ''Philippines, Las Islas Filipinas'' honoring Philip II of Spain and became the official name of the archipelago.
*1543: Ethiopian/Portugal, Portuguese troops decisively defeat the Adal-Ottoman Muslim army led by Imam Ahmad ibn Ibrahim al-Ghazi, Ahmad Gragn at the Battle of Wayna Daga; Imam Ahmad ibn Ibrihim al-Ghazi, Ahmad Gragn is killed at this battle.
* 1543: Nicolaus Copernicus, Copernicus publishes his theory that the Earth and the other planets revolve around the Sun
*1543: The Nanban trade period begins after Portuguese traders make contact with Japan.
*1544: The France, French defeat an Holy Roman Empire, Imperial–Spanish Empire, Spanish army at the Battle of Ceresole.
*1544: Battle of the Shirts in Scottish clan, Scotland. The Clan Fraser, Frasers and Macdonalds of Clan Ranald fight over a disputed chiefship; reportedly, 5 Frasers and 8 Macdonalds survive.
*1545: Songhai Empire, Songhai forces sack the Mali Empire, Malian capital of Niani, Mali, Niani
*1545: The Council of Trent meets for the first time in Trent (in northern Italy).
*1546: Michelangelo Buonarroti is made chief architect of St. Peter's Basilica.
*1546: Francis Xavier works among the peoples of Ambon, Ternate and Morotai (Moro) laying the foundations for a permanent mission. (to 1547)
*1547: Henry VIII of England, Henry VIII dies in the Palace of Whitehall on 28 January at the age of 55.
*1547: Francis I of France, Francis I dies in the Château de Rambouillet on 31 March at the age of 52.
*1547: Edward VI of England, Edward VI becomes King of England and Ireland on 28 January and is crowned on 20 February at the age of 9.
*1547: Emperor Charles V, Holy Roman Emperor, Charles V decisively dismantles the Schmalkaldic League at the Battle of Mühlberg.
*1547: Grand Duchy of Moscow, Grand Prince Ivan the Terrible is crowned tsar of (All) Russia, thenceforth becoming the Tsar of Russia#Tsars of Russia, first Russian tsar.
*1548: Battle of Uedahara: Firearms are used for the first time on the battlefield in Japan, and Takeda Shingen is defeated by Murakami Yoshikiyo.
* 1548: Askia Daoud, who reigned from 1548 to 1583, establishes public libraries in Timbuktu (in present-day Mali).
*1548: The Ming Dynasty government of China issues a decree banning all foreign trade and closes down all seaports along the coast; these Hai jin laws came during the Wokou wars with Japanese pirates.
*1549: Tomé de Sousa establishes Salvador, Bahia, Salvador in Bahia, north-east of Brazil.
*1549: Arya Penangsang with the support of his teacher, Sunan Kudus, avenges the death of Raden Kikin by sending an envoy named Rangkud to kill Sunan Prawoto by Keris Kyai Satan Kober (in present-day Indonesia).
1550s
* 1550: The architect Mimar Sinan builds the Süleymaniye Mosque in Istanbul.
* 1550: Mongols led by Altan Khan invade Ming Dynasty, China and besiege Beijing.
* 1550–1551: Valladolid debate concerning the human rights of the Indigenous people of the Americas.
* 1551: Fifth outbreak of sweating sickness in England. John Caius of Shrewsbury writes the first full contemporary account of the symptoms of the disease.
* 1551: North African Barbary pirates, pirates enslave the entire population of the Maltese island Gozo, between 5,000 and 6,000, sending them to Libya.
* 1552: Russia conquers the Khanate of Kazan in central Asia.
* 1552: Jesuit China Mission, Francis Xavier dies.
* 1553: Mary I of England, Mary Tudor becomes the first queen regnant of England and restores the Church of England under Papal authority.
* 1553: The Portuguese people, Portuguese found a settlement at History of Macau, Macau.
* 1554: Missionary, Missionaries José de Anchieta and Manuel da Nóbrega establishes São Paulo, southeast Brazil.
* 1554: Elizabeth I of England, Princess Elizabeth is imprisoned in the Tower of London upon the orders of Mary I of England, Mary I for suspicion of being involved in the Wyatt's rebellion, Wyatt rebellion.
* 1555: The Muscovy Company is the first major English Joint stock company, joint stock trading company.
* 1556: Publication in Venice of Delle Navigiationi et Viaggi (terzo volume) by Giovanni Battista Ramusio, secretary of Council of Ten, with plan ''La Terra de Hochelaga'', an illustration of the Hochelaga (village), Hochelaga.
* 1556: The Shaanxi earthquake in China is history's deadliest known earthquake during the Ming dynasty.
* 1556: Georgius Agricola, the "Father of Mineralogy", publishes his ''De re metallica''.
* 1556: Akbar defeats Hemu at the Second battle of Panipat.
* 1556: Russia conquers the Astrakhan Khanate.
* 1556–1605: During his reign, Akbar expands the Mughal Empire in a series of conquests (in the Indian subcontinent).
* 1556: Mir Chakar Khan Rind captures Delhi with Humayun.
* 1556: Pomponio Algerio, radical theologian, is executed by boiling in oil as part of the Roman inquisition.
* 1557: Habsburg Spain declares bankruptcy. Philip II of Spain had to declare four National bankruptcy, state bankruptcies in 1557, 1560, 1575 and 1596.
* 1557: The Portuguese people, Portuguese settle in Macau (on the western side of the Pearl River Delta across from present-day Hong Kong).
* 1557: The Ottoman Empire, Ottomans capture Massawa, all but isolating Ethiopia from the rest of the world.
* 1558: Elizabeth I of England, Elizabeth Tudor becomes Queen Elizabeth I at age 25.
* 1558–1603: The Elizabethan era is considered the height of the English Renaissance.
* 1558–1583: Livonian War between Poland, Grand Principality of Lithuania, Sweden, Denmark and Russia.
* 1558: After 200 years, the Kingdom of England loses Calais to France.
* 1559: With the Peace of Cateau Cambrésis, the Italian Wars conclude.
* 1559: Sultan Hairun of Ternate (in present-day Indonesia) protests the Portuguese's Christianity, Christianisation activities in his lands. Hostilities between Sultanate of Ternate, Ternate and the Portuguese.
1560s
* 1560: Ottoman navy defeats the Spanish Empire, Spanish fleet at the Battle of Djerba.
* 1560: Elizabeth Bathory is born in Nyirbator, Hungary.
* 1560: By winning the Battle of Okehazama, Oda Nobunaga becomes one of the pre-eminent warlords of Japan.
* 1560: Jeanne d'Albret declares Calvinism the official religion of Kingdom of Navarre, Navarre.
* 1560: St. Lazarus' Church, Macau, Lazarus Church, Macau
* 1561: Sir Francis Bacon is born in London.
* 1561: The battles of Kawanakajima, fourth battle of Kawanakajima between the Uesugi and Takeda at Hachimanbara takes place.
* 1561: Guido de Bres draws up the Belgic Confession of Protestant faith.
* 1562: Mughal Empire, Mughal emperor Akbar reconciles the Muslim and Hindu factions by marrying into the powerful Rajput Hindu caste.
* 1562–1598: French Wars of Religion between Catholics and Huguenots.
* 1562: Massacre of Wassy and Battle of Dreux in the French Wars of Religion.
* 1562: Portuguese Dominican Order, Dominican priests build a palm-trunk fortress which Javanese people, Javanese Muslims burned down the following year. The fort was rebuilt from more durable materials and the Dominicans commenced the Christianity, Christianisation of the local population.
* 1563: Black Death, Plague outbreak claimed 80,000 people in Elizabethan era, Elizabethan Kingdom of England, England. In London alone, over 20,000 people died of the disease.
* 1564: Galileo Galilei born on February 15
* 1564: William Shakespeare baptized 26 April
* 1565: Deccan sultanates defeat the Vijayanagara Empireat the Battle of Talikota.
* 1565: Mir Chakar Khan Rind dies at aged 97.
* 1565: Estácio de Sá establishes Rio de Janeiro in Brazil.
* 1565: The Knights Hospitaller, Hospitallers, a Crusading Order, defeat the Ottoman Empire at the siege of Malta (1565).
* 1565: Miguel López de Legazpi establishes in Cebu the first Spanish settlement in the Philippines starting a period of Spanish colonization that would last over three hundred years.
* 1565: Spanish navigator Andres de Urdaneta discovers the maritime route from Asia to the Americas across the Pacific Ocean, also known as the ''tornaviaje''.
* 1565: Royal Exchange, London, Royal Exchange is founded by Thomas Gresham.
* 1566: Suleiman the Magnificent, ruler of the Ottoman Empire, dies on September 7, during the battle of Szigetvar.
* 1566–1648: Eighty Years' War between Spain and the Netherlands.
* 1566: Da le Balle Contrade d'Oriente, composed by Cipriano de Rore.
* 1567: After 45 years' reign, Jiajing Emperor died in the Forbidden City, Longqing Emperor ascended the throne of Ming Dynasty.
* 1567: Mary, Queen of Scots, is imprisoned by Elizabeth I.
* 1568: The Principality of Transylvania (1570–1711), Transylvanian Diet (assembly), Diet, under the patronage of the prince John Sigismund Zápolya, the former king of Hungary, inspired by the teachings of Ferenc Dávid, the founder of the Unitarian Church of Transylvania, promulgates the Edict of Torda, the first law of freedom of religion and of conscience in the World.
* 1568–1571: Morisco Revolt in Spain.
* 1568–1600: The Azuchi-Momoyama period in Japan.
* 1568: Hadiwijaya sent his adopted son and son in-law Senopati, Sutawijaya, who would later become the first ruler of the Mataram Sultanate, Mataram dynasty of Indonesia, to kill Arya Penangsang.
* 1569: Rising of the North in England.
* 1569: Mercator 1569 world map published by Gerardus Mercator.
* 1569: The Polish–Lithuanian Commonwealth is created with the Union of Lublin which lasts until 1795.
* 1569: Peace treaty signed by Sultan Hairun of Ternate and Governor Lopez De Mesquita of Portugal.
1570s
* 1570: Ivan the Terrible, tsar of Russia, orders the massacre of inhabitants of Novgorod.
* 1570: Pope Pius V issues ''Regnans in Excelsis'', a papal bull excommunicating all who obeyed Elizabeth I and calling on all Catholics to rebel against her.
* 1570: Sultan Hairun of Ternate (in present-day Indonesia) is killed by the Portuguese. Babullah of Ternate, Babullah becomes the next Sultan.
* 1571: Pope Pius V completes the Holy League (Mediterranean), Holy League as a united front against the Ottoman Empire, Ottoman Turks.
* 1571: The Spanish-led Holy League navy destroys the Ottoman Empire navy at the Battle of Lepanto (1571), Battle of Lepanto.
* 1571: Crimean Khanate, Crimean Tatars attack and Russo-Crimean Wars, sack Moscow, burning everything but the Moscow Kremlin, Kremlin.
* 1571: Native Americans in the United States, American Indians kill Spanish missionaries in what would later be Jamestown, Virginia.
* 1571: Spanish conquistador Miguel López de Legazpi establishes Manila, Philippines as the capital of the Spanish East Indies.
* 1572: Brielle is taken from Habsburg Spain by Protestant Watergeuzen in the Capture of Brielle, in the Eighty Years' War.
* 1572: Conquistador, Spanish conquistadores apprehend the last Inca Empire, Inca leader Tupak Amaru at Vilcabamba, Peru, and execute him in Cuzco.
* 1572: Jeanne d'Albret dies aged 43 and is succeeded by Henry IV of France, Henry of Navarre.
* 1572: Catherine de' Medici instigates the St. Bartholomew's Day massacre which takes the lives of Protestant leader Gaspard II de Coligny, Gaspard de Coligny and thousands of Huguenots. The violence spreads from Paris to other cities and the countryside.
* 1572: First edition of the epic The Lusiads of Luís Vaz de Camões, three years after the author returned from the East.
* 1572: The 9 years old Crown prince, Taizi, Zhu Yijun ascended the throne of Ming Dynasty, known as Wanli Emperor.
* 1573: After heavy losses on both sides the siege of Haarlem ends in a Spain, Spanish victory.
* 1574: in the Eighty Years' War the capital of County of Zeeland, Zeeland, Middelburg, Zeeland, Middelburg declares for the Protestants.
* 1574: After a siege of 4 months the siege of Leiden ends in a comprehensive Dutch Revolt, Dutch rebel victory.
* 1575: Oda Nobunaga finally captures Nagashima fortress.
* 1575: Following a five-year war, the Ternateans under Sultan Babullah of Ternate, Babullah defeated the Portuguese.
* 1576: Tahmasp I, Safavid shah, dies.
* 1576: The Battle of Haldighati is fought between the ruler of Mewar, Maharana Pratap and the Mughal Empire's forces under Emperor Akbar led by Raja Man Singh.
* 1576: Sack of Antwerp by badly paid Spaniards, Spanish soldiers.
* 1577–1580: Francis Drake Circumnavigation, circles the world.
* 1577: Ki Ageng Pemanahan built his palace in Pasargede or Kotagede.
* 1578: King Sebastian of Portugal is killed at the Battle of Alcazarquivir.
* 1578: The Portuguese establish a fort on Tidore but the main centre for Portuguese activities in Maluku becomes Ambon.
* 1578: 3rd Dalai Lama, Sonam Gyatso is conferred the title of Dalai Lama by Tumed Mongol ruler, Altan Khan. Recognised as the reincarnation of two previous Lamas, Sonam Gyatso becomes the third Dalai Lama in the lineage.
* 1579: The Union of Utrecht unifies the northern Netherlands, a foundation for the later Dutch Republic.
* 1579: The Union of Arras unifies the southern Netherlands, a foundation for the later states of the Spanish Netherlands, the Austrian Netherlands and Belgium.
* 1579: The British navigator Sir Francis Drake passes through Maluku and transit in Ternate on his circumnavigation of the world. The Portuguese establish a fort on Tidore but the main centre for Portuguese activities in Maluku becomes Ambon.
1580s
* 1580: Francis Drake, Drake's royal reception after his attacks on Spanish possessions influences Philip II of Spain to build up the Spanish Armada. English ships in Spanish harbours are impounded.
* 1580: Spain unifies with Portugal under Philip II of Spain, Philip II. The struggle for the throne of Portugal ends the Portuguese Empire. The Spanish and Portuguese crowns are Iberian Union, united for 60 years, i.e. until 1640.
* 1580–1587: Nagasaki comes under control of the Jesuits.
* 1581: Dutch Act of Abjuration, declaring abjuring allegiance to Philip II of Spain.
* 1581: Bayinnaung dies at the age of 65.
* 1582: Oda Nobunaga commits seppuku during the Honnō-ji Incident coup by his general, Akechi Mitsuhide.
* 1582: Pope Gregory XIII issues the Gregorian calendar. The last day of the Julian calendar was Thursday, 4 October 1582 and this was followed by the first day of the Gregorian calendar, Friday, 15 October 1582
* 1582: Yermak Timofeyevich conquers the Siberia Khanate on behalf of the Stroganovs.
* 1583: Denmark builds the world's first theme park, Dyrehavsbakken, Bakken.
* 1583: Death of Sultan Babullah of Ternate.
* 1584–1585: After the Siege of Antwerp (1584-1585), siege of Antwerp, many of its merchants flee to Amsterdam. According to Luc-Normand Tellier, "At its peak, between 1510 and 1557, Antwerp concentrated about 40% of the world trade...It is estimated that the port of Antwerp was earning the Spanish crown seven times more revenues than the Spanish colonization of the Americas, Americas."
* 1584: Gedhe Pamanahan, Ki Ageng Pemanahan died. Sultan Pajang raised Sutawijaya, son of Ki Ageng Pemanahan as the new ruler in Mataram Sultanate, Mataram, titled "Loring Ngabehi Market" (because of his home in the north of the market).
* 1585: Akbar annexes Kashmir and adds it to the History of Afghanistan#Mughals, Uzbeks, and Safavids, Kabul Subah
* 1585: Colony at Roanoke Colony, Roanoke founded in North America.
* 1585–1604: The Anglo-Spanish War (1585), Anglo-Spanish War is fought on both sides of the Atlantic.
* 1587: Mary, Queen of Scots is executed by Elizabeth I.
* 1587: The reign of Abbas I of Persia, Abbas I marks the zenith of the Safavid dynasty.
* 1587: Troops that would invade Pajang Mataram Sultanate storm ravaged the eruption of Mount Merapi. Sutawijaya and his men survived.
* 1588: Mataram into the kingdom with Sutawijaya as Sultan, titled "Senapati Ingalaga Sayidin Panatagama" means the warlord and cleric Manager Religious Life.
* 1588: England repulses the Spanish Armada.
* 1589: Spain repulses the English Armada.
* 1589: Catherine de' Medici dies at aged 69.
1590–1600
* 1590: Siege of Odawara (1590), Siege of Odawara: the Late Hōjō clan, Go-Hojo clan surrender to Toyotomi Hideyoshi, and Japan is unified.
* 1591: List of Crimean khans, Gazi Giray leads a huge Tatar expedition against Moscow.
* 1591: In Mali, Morocco, Moroccan forces of the Sultan Ahmad I al-Mansur Saadi, Ahmad al-Mansur led by Judar Pasha defeat the Songhai Empire at the Battle of Tondibi.
* 1592–1593: John Stow reports 10,675 Black Death, plague deaths in London, a city of approximately 200,000 people.
* 1592–1598: Korea, with the help of Ming Dynasty China, repels Hideyoshi's invasions of Korea, two Japanese invasions.
* 1593–1606: The Long War (Ottoman wars), Long War between the Habsburg monarchy and the Ottoman Empire, Ottoman Turks.
* 1594: St. Paul's College, Macau, founded by Alessandro Valignano.
* 1595: First Dutch expedition to Indonesia sets sail for the East Indies with two hundred and forty-nine men and sixty-four cannons led by Cornelis de Houtman.Ricklefs (1991), page 27
* 1596: Birth of René Descartes.
* 1596: June, de Houtman's expedition reaches Banten the main pepper port of West Java where they clash with both the Portuguese and Indonesians. It then sails east along the north coast of Java losing twelve crew to a Javanese attack at Sidayu and killing a local ruler in Madura.
* 1597: ''Romeo and Juliet'' is published.
* 1597: Cornelis de Houtman's expedition returns to the Netherlands with enough spices to make a considerable profit.
* 1598: The Edict of Nantes ends the French Wars of Religion.
* 1598: Abbas I of Persia, Abbas I moves Safavids capital from Qazvin to Isfahan in 1598.
* 1598–1613: Russia descends into anarchy during the Time of Troubles.
* 1598: The Portuguese require an armada of 90 ships to put down a Solorese uprising. (to 1599)
* 1598: More Dutch fleets leave for Indonesia and most are profitable.
* 1598: The province of Santa Fe de Nuevo México is established in Northern New Spain. The region would later become a territory of Mexico, the New Mexico Territory in the United States, and the US State of New Mexico.
* 1598: Death of Toyotomi Hideyoshi, known as the unifier of Japan.
* 1599: The Mali Empire is defeated at the Battle of Jenné.
* 1599: The van Neck expedition returns to Europe. The expedition makes a 400 per cent profit. (to 1600)
* 1599: March, Leaving Europe the previous year, a Second Dutch Expedition to Indonesia (1598-1600), fleet of eight ships under Jacob van Neck was the first Dutch fleet to reach the ‘Spice Islands’ of Maluku.
* 1600: Giordano Bruno is burned at the stake for Christian heresy, heresy in Rome.
* 1600: Battle of Sekigahara in Japan. End of the Sengoku period, Warring States period and beginning of the Edo period.
* 1600: The Portuguese win a major naval battle in the bay of Ambon.Ricklefs (1991), page 28 Later in the year, the Dutch join forces with the local Hituese in an anti-Portuguese alliance, in return for which the Dutch would have the sole right to purchase spices from Hitu.
* 1600: Elizabeth I grants a charter to the British East India Company beginning the English advance in Asia.
* 1600: Michael the Brave unifies the three Romanian principalities: Wallachia, Moldavia and Principality of Transylvania (1570–1711), Transylvania after the Battle of Șelimbăr from 1599.
Undated
*The Histories (Polybius), Polybius' "The Histories" translated into Italian language, Italian, English language, English, German language, German and French language, French.Polybius: "The Rise Of The Roman Empire", Page 36, Penguin, 1979. * Mississippian culture disappears. * Medallion rug, variant Star Ushak style, Anatolia (modern Turkey), is made. It is now kept at The Saint Louis Art Museum.Gallery
Inventions, discoveries, introductions
: ''Related article: Timeline of historic inventions#16th century, List of 16th century inventions.'' * The Columbian Exchange introduces many plants, animals and diseases to the Old World, Old and New Worlds. * Introduction of the spinning wheel revolutionizes textile production in Europe. * The letter J is introduced into the English alphabet. * 1500: First portable watch is created by Peter Henlein of Germany. * 1513: Juan Ponce de León sights Florida and Vasco Núñez de Balboa sights the eastern edge of the Pacific Ocean. * 1519–1522, 22: Ferdinand Magellan and Juan Sebastián Elcano lead the first circumnavigation of the World. * 1519–1540: In America, Hernando de Soto (explorer), Hernando de Soto expeditions map the Gulf of Mexico coastline and bays. * 1525: Modern square root symbol (√) * 1540: Francisco Vásquez de Coronado sights the Grand Canyon. * 1541–1542, 42: Francisco de Orellana sails the length of the Amazon River. * 1542–1543, 43: Firearms are introduced into Japan by the Portuguese people, Portuguese. * 1543: Nicolaus Copernicus, Copernicus publishes his theory that the Earth and the other planets revolve around the Sun * 1545: Theory of complex numbers is first developed by Gerolamo Cardano of Italy. * 1558: Camera obscura is first used in Europe by Giambattista della Porta of Italy. * 1559–1562: Spanish settlements in Alabama/Florida and Georgia (U.S. state), Georgia confirm dangers of hurricanes and local native warring tribes. * 1565: Spanish settlers outside New Spain (Mexico) colonize Florida's coastline at St. Augustine, Florida, St. Augustine. * 1565: Invention of the graphite pencil (in a wooden holder) by Conrad Gesner. Modernized in 1812. * 1568: Gerardus Mercator creates the first Mercator projection map. * 1572: Supernova SN 1572 is observed by Tycho Brahe in the Milky Way. * 1582: Gregorian calendar is introduced in Europe by Pope Gregory XIII and adopted by Catholic countries. * c. 1583: Galileo Galilei of Pisa, Italy identifies the constant swing of a pendulum, leading to development of reliable timekeepers. * 1585: earliest known reference to the 'Wheelbarrow#Chinese sailing carriage, sailing carriage' in China. * 1589: William Lee (inventor), William Lee invents the stocking frame. * 1591: First flush toilet is introduced by John Harington (writer), Sir John Harrington of England, the design published under the title 'The Metamorphosis of Ajax'. * 1593: Galileo Galilei invents a thermometer. * 1596: William Barents discovers Spitsbergen. * 1597: Opera in Florence by Jacopo Peri.See also
*Entertainment in the 16th centuryReferences
Further reading
* Langer, William. ''An Encyclopedia of World History'' (5th ed. 1973); highly detailed outline of eventonline free
External links
*{{DEFAULTSORT:16th Century 16th century, Centuries Early Modern period 2nd millennium