Trypanolytic
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Trypanolytic
A trypanotolerant organism is one which is relatively less affected by trypanosome infestation. By host In livestock Some breeds are known for their trypanotolerance. This is especially important in Africa where a few particular trypanosomes are major economic and agricultural pests. Trypanotolerant livestock breeds * N'Dama cattle * West African Dwarf goats * West African Dwarf sheep (Djallonké) * Cameroon sheep Trypanotolerance of the N'Dama Cattle and West African Dwarf Sheep and Goats Certain domestic ruminant breeds in sub-saharan Africa show remarkable resistance to the effects of African trypanosomiasis: they can tolerate the parasites's presence while controlling parasitaemia levels and, most importantly, do not show the severe anemia and production loss that are typical of infection in susceptible breeds. The trypanotolerance trait is seen in N'Dama cattle, and it refers to the N'Dama cattle's ability to survive in areas with high tsetse fly endemicity, w ...
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Disease Tolerance
Tolerance to infection, or disease tolerance, is a mechanism that host organisms can use to fight parasites or pathogens that attack the host. Tolerance is not equivalent to resistance. Disease resistance is the host trait that prevents infection or reduces the number of pathogens and parasites within or on a host. Tolerance to infection can be illustrated via comparing host performance versus increasing load. This is a reaction norm in which host performance is regressed against increasing disease burden. The slope of the reaction norm defines the degree of tolerance. High tolerance is indicated as a flat slope, i.e., host performance is not influenced by increasing burden. Steep downward slope indicates low tolerance in which host performance is strongly reduced with increasing burden. An upward slope indicates overcompensation in which a host increases its performance with increasing burden. Genetic variation in tolerance and its correlation with resistance, can be quantified usi ...
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Crossbreeds
A crossbreed is an organism with purebred parents of two different breeds, varieties, or populations. A domestic animal of unknown ancestry, where the breed status of only one parent or grandparent is known, may also be called a crossbreed though the term "mixed breed" is technically more accurate. Outcrossing is a type of crossbreeding used within a purebred breed to increase the genetic diversity within the breed, particularly when there is a need to avoid inbreeding. In animal breeding, ''crossbreeds'' are crosses within a single species, while '' hybrids'' are crosses between different species. In plant breeding terminology, the term ''crossbreed'' is uncommon, and no universal term is used to distinguish hybridization or crossing within a population from those between populations, or even those between species. Crossbreeding is the process of breeding such an organism. It can be beneficially used to maintain health and viability of organisms. However, irresponsible crossbree ...
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World Organisation For Animal Health
The World Organisation for Animal Health (WOAH), formerly the (OIE), is an intergovernmental organisation founded in 1924, coordinating, supporting and promoting animal disease control. The primary objective of WOAH is to control epizootic diseases and prevent their spread. Further objectives include the sharing of transparent, scientific information; international solidarity; sanitary safety; and the promotion of veterinary services‚ food safety and animal welfare. WOAH is recognised by the World Trade Organization, World Trade Organisation (WTO) as an international reference for the safe trade of animals and animal products regarding risks due to animal diseases and zoonoses. WOAH is not a part of the United Nations (UN) system. Its autonomy is institutional and financial, and its own constitutional texts govern its activities. Since its first General Session held in Paris, the Organisation has carried out its work under the authority of a committee consisting of delegates ...
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The Gambia
The Gambia, officially the Republic of The Gambia, is a country in West Africa. Geographically, The Gambia is the List of African countries by area, smallest country in continental Africa; it is surrounded by Senegal on all sides except for the western part, which is bordered by the Atlantic Ocean.Hoare, Ben. (2002) ''The Kingfisher A–Z Encyclopedia'', Kingfisher Publications. p. 11. . Its territory is on both sides of the lower reaches of the Gambia River, which flows through the centre of the country and empties into the Atlantic. The national namesake river demarcates the elongated shape of the country, which has an area of and a population of 2,769,075 people in 2024 which is a 47% population increase from 2013. The capital city is Banjul, which has the most extensive metropolitan area in the country. The second and third-largest cities are Serekunda and Brikama. Arab Muslims, Arab Muslim merchants traded with indigenous West Africans in The Gambia throughout the 9th ...
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Morris Soller
Morris Soller (; born 1931) is an American-Israeli research professor in the Department of Genetics of the Hebrew University of Jerusalem. He is especially interested in livestock genetics, livestock- and crop genetics, crop- genetics including trypanotolerance in cattle. Early life and education Soller was born in Manhattan, New York City in 1931. At the age of 12 he was first inspired to learn about genetics by reading The Theory of the Gene by Thomas Hunt Morgan. . While an undergraduate he read Jay Laurence Lush's ''Animal Breeding Plans'' and learned much from it and would receive the award named for Lush 50 years later see below. Soller also learned much from the writings of Ronald Fisher and Sewall Wright during this time. In 1951 he earned a Bachelor's Degree in Agriculture and then in 1956 both a Master's Degree in applied statistics, Applied Statistics and a Doctorate of Philosophy in animal breeding, Animal Breeding from Rutgers University. He would later return to his ...
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International Livestock Research Institute
The International Livestock Research Institute or ILRI is an international agricultural research institute within the CGIAR – formerly the Consultative Group for International Agricultural Research. It was established in 1994 by merger of the International Laboratory for Research on Animal Diseases in Nairobi in Kenya, and the International Livestock Centre for Africa in Addis Ababa in Ethiopia. It is a non-profit, non-governmental organisation. Its research is intended to help to build sustainable livestock pathways out of poverty in low-income countries and to help people in those countries to keep their farm animals alive and productive, to increase and sustain their livestock and farm productivity, and to find profitable markets for their animal products. Research covers five broad areas: the natural environment; food; gender; health; and prosperity. References

{{authority control International research institutes Agricultural research institutes Research in ...
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Hypothesis
A hypothesis (: hypotheses) is a proposed explanation for a phenomenon. A scientific hypothesis must be based on observations and make a testable and reproducible prediction about reality, in a process beginning with an educated guess or thought. If a hypothesis is repeatedly independently demonstrated by experiment to be true, it becomes a scientific theory. In colloquial usage, the words "hypothesis" and "theory" are often used interchangeably, but this is incorrect in the context of science. A working hypothesis is a provisionally-accepted hypothesis used for the purpose of pursuing further progress in research. Working hypotheses are frequently discarded, and often proposed with knowledge (and warning) that they are incomplete and thus false, with the intent of moving research in at least somewhat the right direction, especially when scientists are stuck on an issue and brainstorming ideas. A different meaning of the term ''hypothesis'' is used in formal l ...
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Trypanosoma
''Trypanosoma'' is a genus of kinetoplastids (class Trypanosomatidae), a monophyletic group of unicellular parasitic flagellate protozoa. Trypanosoma is part of the phylum Euglenozoa. The name is derived from the Ancient Greek ''trypano-'' (borer) and ''soma'' (body) because of their corkscrew-like motion. Most trypanosomes are heteroxenous (requiring more than one obligatory host to complete life cycle) and most are transmitted via a vector. The majority of species are transmitted by blood-feeding invertebrates, but there are different mechanisms among the varying species. '' Trypanosoma equiperdum'' is spread between horses and other equine species by sexual contact. They are generally found in the intestine of their invertebrate host, but normally occupy the bloodstream or an intracellular environment in the vertebrate host. Trypanosomes infect a variety of hosts and cause various diseases, including the fatal human diseases sleeping sickness, caused by '' Trypanosoma br ...
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Dose (biochemistry)
A dose is a measured quantity of a medicine, nutrient, or pathogen that is delivered as a unit. The greater the quantity delivered, the larger the dose. Doses are most commonly measured for compounds in medicine. The term is usually applied to the quantity of a drug or other agent administered for therapeutic purposes, but may be used to describe any case where a substance is introduced to the body. In nutrition, the term is usually applied to how much of a specific nutrient is in a person's diet or in a particular food, meal, or dietary supplement. For bacterial or Virus, viral agents, dose typically refers to the amount of the pathogen required to infect a host. In clinical pharmacology, ''dose'' refers to the amount of drug administered to a person, and Dosage (pharmacology), ''dosage'' is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week"). Exposure assessment, '' ...
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Immunological
Immunology is a branch of biology and medicine that covers the study of immune systems in all organisms. Immunology charts, measures, and contextualizes the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); and the physical, chemical, and physiological characteristics of the components of the immune system ''in vitro'', '' in situ'', and '' in vivo''. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, rheumatology, virology, bacteriology, parasitology, psychiatry, and dermatology. The term was coined by Russian biologist Ilya Ilyich Mechnikov, who advanced studies on immunology and received the Nobel Prize for his work in 1908 with Paul Ehrlich "in recognition of their work on immunity". He pinned small ...
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Resistance (ecology)
In the context of ecological stability, resistance is the property of community (ecology), communities or populations to remain "essentially unchanged" when subject to disturbance (ecology), disturbance. The inverse of resistance is sensitivity. Stability and disturbance Resistance is one of the major aspects of ecological stability. Volker Grimm and Christian Wissel identified 70 terms and 163 distinct definitions of the various aspects of ecological stability, but found that they could be reduced to three fundamental properties: "staying essentially unchanged", "returning to the reference state...after a temporary disturbance" and "persistence through time of an ecological system." Resistant communities are able to remain "essentially unchanged" despite disturbance. Although commonly seen as distinct from resilience (ecology), resilience, Brian Walker (ecologist), Brian Walker and colleagues considered resistance to be a component of resilience in their expanded definition of resi ...
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