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Tick-borne Meningoencephalitis
Tick-borne encephalitis (TBE) is a viral infectious disease involving the central nervous system. The disease most often manifests as meningitis, encephalitis or meningoencephalitis. Myelitis and spinal paralysis also occur. In about one third of cases sequelae, predominantly cognitive dysfunction, persist for a year or more. The number of reported cases has been increasing in most countries. TBE is posing a concerning health challenge to Europe, as the number of reported human cases of TBE in all endemic regions of Europe has increased by almost 400% within the last three decades. The tick-borne encephalitis virus is known to infect a range of hosts including ruminants, birds, rodents, carnivores, horses, and humans. The disease can also be spread from animals to humans, with ruminants and dogs providing the principal source of infection for humans.
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Infectious Disease (speciality)
Infectious diseases (ID), also known as infectiology, is a medical specialty dealing with the diagnosis and treatment of infections. An infectious diseases specialist's practice consists of managing nosocomial ( healthcare-acquired) infections or community-acquired infections. An ID specialist investigates and determines the cause of a disease (bacteria, virus, parasite, fungus or prions). Once the cause is known, an ID specialist can then run various tests to determine the best drug to treat the disease. While infectious diseases have always been around, the infectious disease specialty did not exist until the late 1900s after scientists and physicians in the 19th century paved the way with research on the sources of infectious disease and the development of vaccines. Scope Infectious diseases specialists typically serve as consultants to other physicians in cases of complex infections, and often manage patients with HIV/AIDS and other forms of immunodeficiency. Although many co ...
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Biphasic Disease
A biphasic disease is a disease which has two distinct phases or components. In clinically biphasic diseases, the phases are generally chronologically separated. In histopathologically biphasic tumors (also called biplastic tumors), there is neoplastic A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ... tissue which contains two different cellular elements. Examples Clinically biphasic diseases Tumor biplasia References {{Reflist Diseases and disorders ...
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Pasteurization
In food processing, pasteurization (American and British English spelling differences#-ise, -ize (-isation, -ization), also pasteurisation) is a process of food preservation in which packaged foods (e.g., milk and fruit juices) are treated with mild heat, usually to less than , to eliminate pathogens and extend shelf life. Pasteurization either destroys or deactivates microorganisms and enzymes that contribute to food spoilage or the risk of disease, including vegetative bacteria, but most Endospore, bacterial spores survive the process. Pasteurization is named after the French microbiologist Louis Pasteur, whose research in the 1860s demonstrated that thermal processing would deactivate unwanted microorganisms in wine. Spoilage enzymes are also inactivated during pasteurization. Today, pasteurization is used widely in the dairy industry and other food processing industries for food preservation and food safety. By the year 1999, most liquid products were heat treated in a co ...
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Tick
Ticks are parasitic arachnids of the order Ixodida. They are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, and species, but can become larger when engorged. Ticks are external parasites, living by feeding on the blood of mammals, birds, and sometimes reptiles and amphibians. The timing of the origin of ticks is uncertain, though the oldest known tick fossils are around 100 million years old, and come from the Cretaceous period. Ticks are widely distributed around the world, especially in warm, humid climates. Ticks belong to two major families: the Ixodidae, or hard ticks, and the Argasidae, or soft ticks. '' Nuttalliella'', a genus of tick from southern Africa, is the only member of the family Nuttalliellidae, and represents the most primitive living lineage of ticks. Adults have ovoid/pear-shaped bodies (idiosomas) which become engorged with blood when they feed, and eight legs. Their cephalotho ...
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Woodland
A woodland () is, in the broad sense, land covered with woody plants (trees and shrubs), or in a narrow sense, synonymous with wood (or in the U.S., the '' plurale tantum'' woods), a low-density forest forming open habitats with plenty of sunlight and limited shade (see differences between British, American and Australian English explained below). Some savannas may also be woodlands, such as ''savanna woodland'', where trees and shrubs form a light canopy. Woodlands may support an understory of shrubs and herbaceous plants including grasses. Woodland may form a transition to shrubland under drier conditions or during early stages of primary or secondary succession. Higher-density areas of trees with a largely closed canopy that provides extensive and nearly continuous shade are often referred to as forests. Extensive efforts by conservationist groups have been made to preserve woodlands from urbanization and agriculture. For example, the woodlands of Northwest Indiana ha ...
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Ixodes Persulcatus
''Ixodes persulcatus'', the taiga tick, is a species of hard-bodied tick distributed from Europe through central and northern Asia to China and Japan. The sexual dimorphism of the species is marked, the male being much smaller than the female. Hosts include wild and domestic ungulates, man, dog, rabbit, and other small mammals, including the dormouse, Amur hedgehog, and occasionally birds. Disease transmission ''Ixodes persulcatus'' ticks transmit Lyme disease, relapsing fever (''Borrelia miyamotoi''), babesiosis, and Siberian (TBEV-Sib) and Far Eastern (TBEV-FE) tick-borne encephalitis, and probably human granulocytic anaplasmosis as well. A recent study of the northernmost tick-borne encephalitis focus in Simo, Finnish Lapland, found ''I. persulcatus'' ticks in scattered foci along the western coast, including the Kokkola archipelago and Närpes Närpes (Finland Swedish: ; ) is a town in Finland, located on the west coast of the country. Närpes is situated in Ostroboth ...
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Ixodes Ricinus
''Ixodes ricinus'', the castor bean tick, is a chiefly European species of hard-bodied tick. It may reach a length of when engorged with a blood meal, and can transmit both bacterial and viral pathogens such as the causative agents of Lyme disease and tick-borne encephalitis. Description In common with other species of ''Ixodes'', ''I. ricinus'' has no eyes and is not ornate; it has no festoons (wrinkles along the posterior margin). The palpi are longer than they are wide, and an anal groove is above the anus. It has a hard dorsal shield which covers the entire opisthosoma (abdomen), but only part of it in females and nymphs. ''I. ricinus'' is the largest of the three common species of ''Ixodes'' in the British Isles (the other two being ''Ixodes canisuga, I. canisuga'', the British dog tick, and ''Ixodes trianguliceps, I. trianguliceps'', the vole tick). Adult males are long, and unfed nymphs are long; females are long before feeding and long when eng ...
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Lev Zilber
Lev Aleksandrovich Zilber (; March 27 [Old Style and New Style dates, O.S. March 15], 1894 – November 10, 1966) was a Soviet Microbiologist, micro-biologist, Virology, virologist, and Immunology, immunologist; academician of the USSR Academy of Medical Sciences (AMN SSSR; 1945), founder of the Soviet school of virology. The elder brother of the writer Veniamin Kaverin. Biography Zilber was born on March 15 [Old Style and New Style dates, O.S. March 27] 1894 in the family of the kapellmeister Abel Zilber and his wife, née Khana Girshevna (Anna Grigorievna) Desson, pianist and owner of music stores. Place of birth – the village of Medved, Medved volost, Novgorod Governorate. His sister Leya (married Elena Aleksandrovna Tynyanova, 1892–1944) is the wife of the writer and literary critic Yury Tynyanov, a classmate of Lev Zilber. His younger brothers: Military medicine, military doctor David Zilber (1897–1967), composer and conductor Alexander Ruchiov (1899–1970) and wri ...
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Flaviviridae
''Flaviviridae'' is a family of Viral envelope, enveloped positive-strand RNA viruses which mainly infect mammals and birds. They are primarily spread through arthropod vector (epidemiology), vectors (mainly ticks and mosquitoes). The family gets its name from the yellow fever virus; ''flavus'' is Latin for "yellow", and yellow fever in turn was named because of its propensity to cause jaundice in victims. There are 89 species in the family divided among four genera. Diseases associated with the group include: hepatitis (hepaciviruses), Bleeding, hemorrhagic syndromes, Bovine viral diarrhea, fatal mucosal disease (pestiviruses), Viral hemorrhagic fever, hemorrhagic fever, encephalitis, and the birth defect microcephaly (flaviviruses). Structure Virus particles are enveloped and spherical with icosahedral-like geometries that have pseudo T=3 symmetry. They are about 40–60 nanometer, nm in diameter. Genome Members of the family ''Flaviviridae'' have monopartite, linear, single ...
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Flavivirus
''Flavivirus'', renamed ''Orthoflavivirus'' in 2023, is a genus of positive-strand RNA viruses in the family ''Flaviviridae''. The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis, as well as insect-specific flaviviruses (ISFs) such as cell fusing agent virus (CFAV), Palm Creek virus (PCV), and Parramatta River virus (PaRV). While dual-host flaviviruses can infect vertebrates as well as arthropods, insect-specific flaviviruses are restricted to their competent arthropods. The means by which flaviviruses establish persistent infection in their competent vectors and cause disease in humans depends upon several virus-host interactions, including the intricate interplay between flavivirus-encoded immune antagonists and the host antiviral innate immune effector molecules. Flaviviruses are named for the yellow fever virus; the word ''flavus'' means 'yellow' in Lat ...
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Seizure
A seizure is a sudden, brief disruption of brain activity caused by abnormal, excessive, or synchronous neuronal firing. Depending on the regions of the brain involved, seizures can lead to changes in movement, sensation, behavior, awareness, or consciousness. Symptoms vary widely. Some seizures involve subtle changes, such as brief lapses in attention or awareness (as seen in absence seizures), while others cause generalized convulsions with loss of consciousness ( tonic–clonic seizures). Most seizures last less than two minutes and are followed by a postictal period of confusion, fatigue, or other symptoms. A seizure lasting longer than five minutes is a medical emergency known as status epilepticus. Seizures are classified as provoked, when triggered by a known cause such as fever, head trauma, or metabolic imbalance, or unprovoked, when no immediate trigger is identified. Recurrent unprovoked seizures define the neurological condition epilepsy. Clinical features Seizur ...
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