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Periodontal Pathogen
Well studied Periodontal pathogens are bacteria that have been shown to significantly contribute to periodontitis. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect bacteria - bacteriophages - are most common in the oral cavity. Viral roles in the progression of periodontal disease as of 2017 remains poorly explored. Although approximately 700 bacterial species have been identified in the oral cavity and nearly 300 species have been cultured and found to contribute to the biofilm of the periodontal pocket, there is a much smaller number of species that have been shown to be more closely related to the initial incidence and continued persistence of periodontitis, including: * ''Aggregatibacter actinomycetemcomitans'' * ''Porphyromonas gingivalis'' * '' Tannerella forsythia'' (formerly ''Bacteroides forsythus'') * ''Treponema denticola'' * ''Fusobact ...
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Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, Hot spring, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the nitrogen fixation, fixation of nitrogen from the Earth's atmosphere, atmosphere. The nutrient cycle includes the decomposition of cadaver, dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulp ...
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Prevotella Intermedia
''Prevotella intermedia'' (formerly ''Bacteroides intermedius'') is a gram-negative, obligate anaerobic pathogenic bacterium involved in periodontal infections, including gingivitis and periodontitis, and often found in acute necrotizing ulcerative gingivitis. It is commonly isolated from dental abscesses, where obligate anaerobes predominate. ''P. intermedia'' is thought to be more prevalent in patients with noma. ''P. intermedia'' use steroid hormones as growth factors, so their numbers are higher in pregnant women. It has also been isolated from women with bacterial vaginosis Bacterial vaginosis (BV) is a disease of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urinati .... See also * Oral microbiology * List of bacterial vaginosis microbiota References External links Type strain of ''Prevotella intermedia'' ...
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Red Complex
The red complex is a group of bacteria that are categorized together based on their association with severe forms of periodontal disease. The red complex—among a number of other complexes—were classified by Sigmund Socransky in 1998. The three members of the red complex are: # ''Porphyromonas gingivalis'' # '' Tannerella forsythia'' # ''Treponema denticola ''Treponema denticola'' is a Gram-negative, obligate anaerobic, motile and highly proteolytic spirochete bacterium. It is one of four species of oral spirochetes to be reliably cultured, the others being ''Treponema pectinovorum, Treponema socra ...'' References {{dentistry-stub Periodontology ...
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Selenomonas Noxia
Selenomonas noxia is gram-negative crescent-shaped bacteria included in the genus ''Selenomonas''. Its increase is associated with periodontitis Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. In its early stage, called gingivitis, the gums become swollen and red and may bleed. It is considered the main cau ..., especially its onset, as well as predominant in 98% of obese women in one study, but also is present in modest amounts in healthy gum tissue. References Bacteria described in 1987 Negativicutes {{disease-stub ...
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Candida (fungus)
''Candida'' is a genus of yeasts and is the most common cause of fungal infections worldwide. Many species are harmless commensals or endosymbionts of hosts including humans; however, when mucosal barriers are disrupted or the immune system is compromised they can invade and cause disease, known as an opportunistic infection. Candida is located on most mucosal surfaces and mainly the gastrointestinal tract, along with the skin. ''Candida albicans'' is the most commonly isolated species and can cause infections ( candidiasis or thrush) in humans and other animals. In winemaking, some species of ''Candida'' can potentially spoil wines. Many species are found in gut flora, including ''C. albicans'' in mammalian hosts, whereas others live as endosymbionts in insect hosts. Systemic infections of the bloodstream and major organs (candidemia or invasive candidiasis), particularly in patients with an impaired immune system (immunocompromised), affect over 90,000 people a year in the U ...
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Capnocytophaga
''Capnocytophaga'' is a genus of Gram-negative bacteria. Normally found in the oropharyngeal tract of mammals, they are involved in the pathogenesis of some animal bite wounds and periodontal diseases. Taxonomy The term ''Capnocytophaga'' comes from "wikt:capno-, capno-" for its dependence on CO2 and "cytophaga" for its flexibility and mobility shift (gliding motility). It belongs to the family Flavobacteriaceae, order Flavobacteriales. This genus includes eight different species: ''C. ochracea'', ''C. gingivalis'', ''C. granulosa'', ''C. haemolytica'', ''C. sputigena'', ''C. leadbetteri'' (isolated oral cavity of humans), ''C. canimorsus'', and ''C. cynodegmi'' (isolated from the oral cavity of animals). Many strains have also been described whose classification remains uncertain. Bacteriological isolation and identification ''Capnocytophaga'' spp. are wikt:fusiform, fusiform Gram-negative bacilli, and are part of the oral commensalism, commensal flora. Microscopic observat ...
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Campylobacter Rectus
''Campylobacter rectus'' is a species of '' Campylobacter''. It is implicated as a pathogen in chronic periodontitis, which can induce bone loss. This motile bacillus is a Gram negative, facultative anaerobe. ''C. rectus'' is associated with hypertension together with ''Prevotella melaninogenica'' and ''Veillonella parvula ''Veillonella parvula'' is a strictly anaerobic, Gram-negative, coccus-shaped bacterium in the genus '' Veillonella''. It is a normal part of the oral flora but can be associated with diseases such as periodontitis and dental caries as well as va ...''. References Further reading * External linksType strain of ''Campylobacter rectus'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Campylobacterota Bacteria described in 1991 {{Campylobacterota-stub ...
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Streptococcus Intermedius
''Streptococcus intermedius'' is an aerotolerant anaerobic commensal bacterium and a member of the ''Streptococcus anginosus'' group. The ''S. anginosus'' group, occasionally termed “''Streptococcus milleri'' group” (SMG) display hemolytic and serologic diversity, yet share core physiological traits. Despite being commensal organisms, members of the ''S. anginosus'' group display wide pathogenic potential. ''S. intermedius'' has been isolated from patients with periodontitis and fatal purulent infections, especially brain and liver abscesses.Claridge, J. E., III, S. Attorri, D. M. Musher, J. Hebert, and S. Dunbar. 2001. ''Streptococcus intermedius'', ''Streptococcus constellatus'', and Streptococcus ''anginosus'' (“''Streptococcus milleri'' group”) are of different clinical importance and are not equally associated with abscess. Clin. Infect. Dis. 32:1511–1515.Whiley, R. A., D. Beighton, T. G. Winstanley, H. Y. Fraser, and J. M. Hardie. 1992. ''Streptococcus intermedius ...
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Peptostreptococcus
''Peptostreptococcus'' is a genus of anaerobic, Gram-positive, non-spore forming bacteria. The cells are small, spherical, and can occur in short chains, in pairs or individually. They typically move using cilia. ''Peptostreptococcus'' are slow-growing bacteria with increasing resistance to antimicrobial drugs. ''Peptostreptococcus'' is a normal inhabitant of the healthy lower reproductive tract of women. Pathogenesis ''Peptostreptococcus'' species are commensal organisms in humans, living predominantly in the mouth, skin, gastrointestinal, vagina and urinary tracts, and are members of the gut microbiota. Under immunosuppressed or traumatic conditions these organisms can become pathogenic, as well as septicemic, harming their host. ''Peptostreptococcus'' can cause brain, liver, breast, and lung abscesses, as well as generalized necrotizing soft tissue infections. They participate in mixed anaerobic infections, a term which is used to describe infections that are caused by mu ...
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Parvimonas Micra
''Parvimonas micra'' is a Gram positive anaerobic coccus which is frequently isolated from dental plaque in patients with chronic periodontitis. It is the only species in its genus, and is a common constituent of mixed anaerobic infections such as intra-abdominal abscess. It has rarely been implicated as a sole pathogen in septic arthritis, osteomyelitis and discitis Discitis, or diskitis, is an infection in the intervertebral disc space that affects different age groups. In adults, it can lead to severe consequences, such as sepsis or epidural abscess, but it can also spontaneously resolve, especially in ch ... associated with recent dental procedures. References External links Type strain of ''Parvimonas micra'' at Bac''Dive'' - the Bacterial Diversity Metadatabase {{Taxonbar, from=Q26270804 Medically important anaerobes Bacillota ...
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Eubacterium Nodatum
''Eubacterium nodatum'' is a Gram positive member of the oral flora of some patients with chronic periodontitis Chronic periodontitis is one of the seven categories of periodontitis as defined by the American Academy of Periodontology 1999 classification system. Chronic periodontitis is a common disease of the oral cavity consisting of chronic inflammation ....AAP In-Service Exam, 2008-B37 It has been recently added to the red complex bacteria, that are most associated with disease. References External linksType strain of ''Eubacterium nodatum'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Eubacteriaceae Bacteria described in 1980 {{dentistry-stub ...
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Eikenella Corrodens
''Eikenella corrodens'' is a Gram-negative facultative anaerobic bacillus that can cause severe invasive disease in humans. It was first identified by M. Eiken in 1958, who called it ''Bacteroides corrodens''. ''E. corrodens'' is a rare pericarditis associated pathogen. It is a fastidious, slow growing, human commensal bacillus, capable of acting as an opportunistic pathogen and causing abscesses in several anatomical sites, including the liver, lung, spleen, and submandibular region. ''E. corrodens'' could independently cause serious infection in both immunocompetent and immunocompromised hosts. Microbiology ''Eikenella corrodens'' is a pleomorphic bacillus that sometimes appears coccobacillary and typically creates a depression (or "pit") in the agar on which it is growing. Only half produce the pitting of the agar considered characteristic.. It is slow-growing, facultative, anaerobic and a gram-negative bacillus. It grows in aerobic and anaerobic conditions, but requires a ...
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