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Pituitary
In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hypophysis rests upon the hypophyseal fossa of the sphenoid bone in the center of the middle cranial fossa and is surrounded by a small bony cavity ( sella turcica) covered by a dural fold ( diaphragma sellae). The anterior pituitary (or adenohypophysis) is a lobe of the gland that regulates several physiological processes including stress, growth, reproduction, and lactation. The intermediate lobe synthesizes and secretes melanocyte-stimulating hormone. The posterior pituitary (or neurohypophysis) is a lobe of the gland that is functionally connected to the hypothalamus by the median eminence via a small tube called the pituitary stalk (also called the infundibular stalk or the infundibulum). Hormones secreted from the pituitary ...
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Anterior Pituitary
A major organ of the endocrine system, the anterior pituitary (also called the adenohypophysis or pars anterior) is the glandular, anterior lobe that together with the posterior lobe ( posterior pituitary, or the neurohypophysis) makes up the pituitary gland (hypophysis). The anterior pituitary regulates several physiological processes, including stress, growth, reproduction, and lactation. Proper functioning of the anterior pituitary and of the organs it regulates can often be ascertained via blood tests that measure hormone levels. Structure The pituitary gland sits in a protective bony enclosure called the sella turcica (''Turkish chair/saddle''). It is composed of three lobes: the anterior, intermediate, and posterior lobes. In many animals, these lobes are distinct. However, in humans, the intermediate lobe is but a few cell layers thick and indistinct; as a result, it is often considered part of the anterior pituitary. In all animals, the fleshy, glandular anterior pit ...
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Hypothalamus
The hypothalamus () is a part of the brain that contains a number of small nuclei with a variety of functions. One of the most important functions is to link the nervous system to the endocrine system via the pituitary gland. The hypothalamus is located below the thalamus and is part of the limbic system. In the terminology of neuroanatomy, it forms the ventral part of the diencephalon. All vertebrate brains contain a hypothalamus. In humans, it is the size of an almond. The hypothalamus is responsible for regulating certain metabolic processes and other activities of the autonomic nervous system. It synthesizes and secretes certain neurohormones, called releasing hormones or hypothalamic hormones, and these in turn stimulate or inhibit the secretion of hormones from the pituitary gland. The hypothalamus controls body temperature, hunger, important aspects of parenting and maternal attachment behaviours, thirst, fatigue, sleep, and circadian rhythms. Structure Th ...
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Posterior Pituitary
The posterior pituitary (or neurohypophysis) is the posterior lobe of the pituitary gland which is part of the endocrine system. The posterior pituitary is not glandular as is the anterior pituitary. Instead, it is largely a collection of axonal projections from the hypothalamus that terminate behind the anterior pituitary, and serve as a site for the secretion of neurohypophysial hormones ( oxytocin and vasopressin) directly into the blood. The hypothalamic–neurohypophyseal system is composed of the hypothalamus (the paraventricular nucleus and supraoptic nucleus), posterior pituitary, and these axonal projections. Structure The posterior pituitary consists mainly of neuronal projections (axons) of magnocellular neurosecretory cells extending from the supraoptic and paraventricular nuclei of the hypothalamus. These axons store and release neurohypophysial hormones oxytocin and vasopressin into the neurohypophyseal capillaries, from there they get into the systemic ci ...
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Endocrine Gland
Endocrine glands are ductless glands of the endocrine system that secrete their products, hormones, directly into the blood. The major glands of the endocrine system include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus and adrenal glands. The hypothalamus and pituitary glands are neuroendocrine organs. Pituitary gland The pituitary gland hangs from the base of the brain by the pituitary stalk, and is enclosed by bone. It consists of a hormone-producing glandular portion of the anterior pituitary and a neural portion of the posterior pituitary, which is an extension of the hypothalamus. The hypothalamus regulates the hormonal output of the anterior pituitary and creates two hormones that it exports to the posterior pituitary for storage and later release. Four of the six anterior pituitary hormones are tropic hormones that regulate the function of other endocrine organs. Most anterior pituitary hormones exhi ...
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Hypophyseal Fossa
The sella turcica ( Latin for 'Turkish saddle') is a saddle-shaped depression in the body of the sphenoid bone of the human skull and of the skulls of other hominids including chimpanzees, gorillas and orangutans. It serves as a cephalometric landmark. The pituitary gland or hypophysis is located within the most inferior aspect of the sella turcica, the hypophyseal fossa. Structure The sella turcica is located in the sphenoid bone behind the chiasmatic groove and the tuberculum sellae. It belongs to the middle cranial fossa. The sella turcica's most inferior portion is known as the hypophyseal fossa (the "seat of the saddle"), and contains the pituitary gland (hypophysis). In front of the hypophyseal fossa is the tuberculum sellae. Completing the formation of the saddle posteriorly is the dorsum sellae, which is continuous with the clivus, inferoposteriorly. The dorsum sellae is terminated laterally by the posterior clinoid processes. Development It is widely b ...
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Sella Turcica
The sella turcica (Latin for 'Turkish saddle') is a saddle-shaped depression in the body of the sphenoid bone of the human skull and of the skulls of other hominids including chimpanzees, gorillas and orangutans. It serves as a cephalometric landmark. The pituitary gland or hypophysis is located within the most inferior aspect of the sella turcica, the hypophyseal fossa. Structure The sella turcica is located in the sphenoid bone behind the chiasmatic groove and the tuberculum sellae. It belongs to the middle cranial fossa. The sella turcica's most inferior portion is known as the hypophyseal fossa (the "seat of the saddle"), and contains the pituitary gland (hypophysis). In front of the hypophyseal fossa is the tuberculum sellae. Completing the formation of the saddle posteriorly is the dorsum sellae, which is continuous with the clivus, inferoposteriorly. The dorsum sellae is terminated laterally by the posterior clinoid processes. Development It is widely believed ...
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Inferior Hypophyseal Artery
The inferior hypophysial artery is an artery in the head. It is a branch of the cavernous carotid artery, itself from the internal carotid artery. It supplies the posterior pituitary of the pituitary gland. Structure The inferior hypophysial artery is a branch of the cavernous carotid artery, itself from the internal carotid artery. Alternatively, it may arise from the meningohypophyseal artery. It passes across the middle of the cavernous sinus. It reaches the lateral surface of the posterior pituitary. It merges with the other inferior hypophysial artery. The inferior hypophysial artery may give off the medial clival artery. Function The inferior hypophysial artery supplies the pituitary gland, specifically the posterior pituitary (neurohypophysis). It is important for distributing vasopressin into the bloodstream. History The inferior hypophysial artery was first identified in 1860 by Hubert von Luschka. References {{Authority control Arteries of the ...
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head ( cephalization), usually near organs for special senses such as vision, hearing and olfaction. Being the most specialized organ, it is responsible for receiving information from the sensory nervous system, processing those information (thought, cognition, and intelligence) and the coordination of motor control (muscle activity and endocrine system). While invertebrate brains arise from paired segmental ganglia (each of which is only responsible for the respective body segment) of the ventral nerve cord, vertebrate brains develop axially from the midline dorsal nerve cord as a vesicular enlargement at the rostral end of the neural tube, with centralized control over all body segments. All vertebrate brains can be embryonically divided into three parts: the forebrain (prosencep ...
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Median Eminence
The median eminence, part of the inferior boundary of the hypothalamus in the brain, is attached to the infundibulum. The median eminence is a small swelling on the tuber cinereum, posterior to and atop the pituitary stalk; it lies in the area roughly bounded on its posterolateral region by the cerebral peduncles, and on its anterolateral region by the optic chiasm. As one of the seven areas of the brain devoid of a blood–brain barrier, the median eminence is a circumventricular organ having permeable capillaries. Its main function is as a gateway for release of hypothalamic hormones, although it does share contiguous perivascular spaces with the adjacent hypothalamic arcuate nucleus, indicating a potential sensory role. __TOC__ Physiology The median eminence is a part of the hypothalamus from which regulatory hormones are released. It is integral to the hypophyseal portal system, which connects the hypothalamus with the pituitary gland. The pars nervosa (part of the p ...
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Lactation
Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process naturally occurs with all sexually mature female mammals, although it may predate mammals. The process of feeding milk in all animals (including humans) is called ''nursing'', and in humans it is also called '' breastfeeding''. Newborn infants often produce some milk from their own breast tissue, known colloquially as witch's milk. In most species, lactation is a sign that the female has been pregnant at some point in her life, although it can happen without pregnancy. Nearly every species of mammal has nipples; except for monotremes, egg-laying mammals, which instead release milk through ducts in the abdomen. In only one species of mammal, the Dayak fruit bat from Southeast Asia, is milk production a normal male function. ''Galactopoiesis'' is the maintenance of milk production. This stage requires prolactin. Oxytocin is cri ...
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Diaphragma Sellae
The diaphragma sellae or sellar diaphragm is a flat piece of dura mater with a circular hole allowing the vertical passage of the pituitary stalk. It retains the pituitary gland beneath it in the fossa hypophyseos as it almost completely roofs the fossa hypophyseos of the sella turcica, a part of the sphenoid bone. It has a posterior boundary at the dorsum sellae and an anterior boundary at the tuberculum sellae along with the two small eminences (one on either side) called the middle clinoid processes. The diaphragma sellae is innervated by the first division of the cranial trigeminal nerve In neuroanatomy, the trigeminal nerve (literal translation, lit. ''triplet'' nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for Sense, sensation in the face and motor functions .... Surgical Significance Violation of the diaphragma sellae during an endoscopic endonasal transsphenoidal pituitary tumor resection will res ...
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