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Oligoporin D
Oligoporin D is a natural product isolated from the "bitter bracket" mushroom '' Amaropostia stiptica''. It was found to be one of the most potent agonists yet discovered for the bitter taste The gustatory system or sense of taste is the sensory system that is partially responsible for the perception of taste. Taste is the perception stimulated when a substance in the mouth reacts chemically with taste receptor cells located on tas ... receptor TAS2R46, and consequently one of the most bitter substances known. References Natural products Steroids {{pharm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets). The term ''natural product'' has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized meta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amaropostia Stiptica
''Amaropostia stiptica'' is a rare, bitter-tasting species of polypore fungus in the family Fomitopsidaceae. It is known for being one of the most bitter-tasting substances ever tested, surpassing denatonium benzoate in sensory assays. This fungus forms woody, shelf-like fruiting bodies and typically grows on dead or decaying hardwood in tropical and subtropical forests. Description ''Amaropostia stiptica'' produces perennial, sessile, bracket-like fruiting bodies that are hard and woody. The upper surface is typically greyish to brownish and concentrically zoned, while the underside features fine pores. The taste is extraordinarily bitter and immediate, reportedly unbearable in sensory evaluations. Chemistry and bitterness According to a 2025 study, ''A. stiptica'' contains multiple secondary metabolites such as Oligoporin D that activate human bitter taste receptors TAS2R14 and TAS2R46 with remarkable potency. These compounds elicit responses up to 10 times greater than de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bitter Taste
The gustatory system or sense of taste is the sensory system that is partially responsible for the perception of taste. Taste is the perception stimulated when a substance in the mouth reacts chemically with taste receptor cells located on taste buds in the oral cavity, mostly on the tongue. Taste, along with the sense of smell and trigeminal nerve stimulation (registering texture, pain, and temperature), determines flavors of food and other substances. Humans have taste receptors on taste buds and other areas, including the upper surface of the tongue and the epiglottis. The gustatory cortex is responsible for the perception of taste. The tongue is covered with thousands of small bumps called papillae, which are visible to the naked eye. Within each papilla are hundreds of taste buds. The exceptions to this is the filiform papillae that do not contain taste buds. There are between 2000 and 5000Boron, W.F., E.L. Boulpaep. 2003. Medical Physiology. 1st ed. Elsevier Science U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAS2R46
Taste receptor type 2 member 46 is a protein that in humans is encoded by the ''TAS2R46'' gene. Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception. Gene TAS2R46 gene (Taste receptor type 2 member 46) is a protein-coding gene. This gene maps to the taste receptor gene cluster on chromosome 12. hTAS2R46 is a bitter receptor broadly tuned to sesquiterpene lactones, related clerodane diterpenoids, labdane diterpenes and more. Structure In 2022, the solved structure of Tas2r46 was published in the scientific journal Science making it the first Tas2r with a solved structure. The structure of Tas2r46 was solved with cryo-EM and can be downloaded in the Protein Data Bank, under the following names:7xp6 Cryo-EM structure of a class T GPCR in active stat7xp5 Cryo-EM structure of a class T GPCR in ligand-free stat7xp4 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Products
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets). The term ''natural product'' has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized metab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
